Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890719653> ?p ?o ?g. }
- W2890719653 abstract "Abstract Optogenetics provides tools to control afferent activity in brain microcircuits. However, this requires optical methods that can evoke asynchronous and coordinated activity within neuronal ensembles in a spatio-temporally precise way. Here we describe a light patterning method, which combines MHz acousto-optic beam steering and adjustable low numerical aperture Gaussian beams, to achieve fast 2D targeting in scattering tissue. Using mossy fiber afferents to the cerebellar cortex as a testbed, we demonstrate single fiber optogenetic stimulation with micron-scale lateral resolution, >100 µm depth-penetration and 0.1 ms spiking precision. Protracted spatio-temporal patterns of light delivered by our illumination system evoked sustained asynchronous mossy fiber activity with excellent repeatability. Combining optical and electrical stimulations, we show that the cerebellar granular layer performs nonlinear integration, whereby sustained mossy fiber activity provides a permissive context for the transmission of salient inputs, enriching combinatorial views on mossy fiber pattern separation." @default.
- W2890719653 created "2018-09-27" @default.
- W2890719653 creator A5056045862 @default.
- W2890719653 creator A5061569730 @default.
- W2890719653 creator A5077803725 @default.
- W2890719653 creator A5082726463 @default.
- W2890719653 date "2018-09-13" @default.
- W2890719653 modified "2023-10-13" @default.
- W2890719653 title "Optogenetic stimulation of complex spatio-temporal activity patterns by acousto-optic light steering probes cerebellar granular layer integrative properties" @default.
- W2890719653 cites W1021722217 @default.
- W2890719653 cites W148757626 @default.
- W2890719653 cites W1536069924 @default.
- W2890719653 cites W1581369451 @default.
- W2890719653 cites W1965999076 @default.
- W2890719653 cites W1972543620 @default.
- W2890719653 cites W1976435105 @default.
- W2890719653 cites W1983481045 @default.
- W2890719653 cites W1992219804 @default.
- W2890719653 cites W1994321505 @default.
- W2890719653 cites W1996353817 @default.
- W2890719653 cites W1997073648 @default.
- W2890719653 cites W2002429979 @default.
- W2890719653 cites W2002830276 @default.
- W2890719653 cites W2004417373 @default.
- W2890719653 cites W2007081205 @default.
- W2890719653 cites W2009980685 @default.
- W2890719653 cites W2010600019 @default.
- W2890719653 cites W2015520158 @default.
- W2890719653 cites W2015852021 @default.
- W2890719653 cites W2017464919 @default.
- W2890719653 cites W2019307440 @default.
- W2890719653 cites W2023316970 @default.
- W2890719653 cites W2023680021 @default.
- W2890719653 cites W2025791829 @default.
- W2890719653 cites W2026193431 @default.
- W2890719653 cites W2026425363 @default.
- W2890719653 cites W2028513173 @default.
- W2890719653 cites W2029932526 @default.
- W2890719653 cites W2034129279 @default.
- W2890719653 cites W2035755953 @default.
- W2890719653 cites W2037226398 @default.
- W2890719653 cites W2047527379 @default.
- W2890719653 cites W2047541982 @default.
- W2890719653 cites W2048060325 @default.
- W2890719653 cites W2048338001 @default.
- W2890719653 cites W2048844982 @default.
- W2890719653 cites W2049171959 @default.
- W2890719653 cites W2050419854 @default.
- W2890719653 cites W2050932531 @default.
- W2890719653 cites W2052332898 @default.
- W2890719653 cites W2053110645 @default.
- W2890719653 cites W2056356727 @default.
- W2890719653 cites W2058082904 @default.
- W2890719653 cites W2058956617 @default.
- W2890719653 cites W2061744336 @default.
- W2890719653 cites W2063856776 @default.
- W2890719653 cites W2064692246 @default.
- W2890719653 cites W2065514575 @default.
- W2890719653 cites W2065575763 @default.
- W2890719653 cites W2074869013 @default.
- W2890719653 cites W2075107926 @default.
- W2890719653 cites W2076243500 @default.
- W2890719653 cites W2076481913 @default.
- W2890719653 cites W2078769540 @default.
- W2890719653 cites W2078880387 @default.
- W2890719653 cites W2083187476 @default.
- W2890719653 cites W2084100886 @default.
- W2890719653 cites W2085493691 @default.
- W2890719653 cites W2091725272 @default.
- W2890719653 cites W2092853516 @default.
- W2890719653 cites W2097242525 @default.
- W2890719653 cites W2097683070 @default.
- W2890719653 cites W2099386789 @default.
- W2890719653 cites W2103019454 @default.
- W2890719653 cites W2105949133 @default.
- W2890719653 cites W2109164945 @default.
- W2890719653 cites W2109251081 @default.
- W2890719653 cites W2112357421 @default.
- W2890719653 cites W2112938540 @default.
- W2890719653 cites W2114925267 @default.
- W2890719653 cites W2119070939 @default.
- W2890719653 cites W2119686246 @default.
- W2890719653 cites W2123180929 @default.
- W2890719653 cites W2127420062 @default.
- W2890719653 cites W2127462566 @default.
- W2890719653 cites W2132509901 @default.
- W2890719653 cites W2147249695 @default.
- W2890719653 cites W2147607085 @default.
- W2890719653 cites W2155051950 @default.
- W2890719653 cites W2156814492 @default.
- W2890719653 cites W2159423248 @default.
- W2890719653 cites W2160779028 @default.
- W2890719653 cites W2160961804 @default.
- W2890719653 cites W2161370512 @default.
- W2890719653 cites W2167095271 @default.
- W2890719653 cites W2167578079 @default.
- W2890719653 cites W2293817841 @default.
- W2890719653 cites W2296316152 @default.
- W2890719653 cites W2298425537 @default.
- W2890719653 cites W2441241804 @default.