FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890720744> ?p ?o ?g. }

• W2890720744 abstract "8020 Background: Circulating plasma cells (CPCs) at diagnosis, prior to transplant and at relapse have a negative prognostic impact on survival in multiple myeloma (MM). However, the impact of changes in CPCs along the course of illness has not been defined. Methods: We evaluated 247 patients with newly diagnosed MM (NDMM) undergoing early autologous stem cell transplantation (ASCT) in the era of novel agents (2007 to 2015), who had serial evaluation of CPCs at diagnosis and pre-ASCT by 6-color flow cytometry. Results: The median age at transplant was 62 years.A total of 117 (47%) patients had no detectable CPCs at both time points (CPC-/-), 82 (33%) had CPCs at diagnosis followed by complete eradication after induction therapy (CPC+/-) and 48 (19%) had detectable clonal CPCs at transplant, with persistence of cells (CPC+/+; n=45) or emergence of new CPCs (CPC-/+; n=3) after induction. The incidence of t(11;14) by iFISH was lower in the CPC-/- group (19%) compared to CPC+/- (29%) and CPC +/+ or -/+ (39%) groups ( p=0.033). Conversely, the incidence of hyperdiploidy was significantly higher in patients with CPC-/-, compared to those with CPC+/- and CPC+/+ or -/+ (64%, 44% and 39% respectively; p=0.005). The rate of post-ASCT stringent complete response was 32% in the CPC-/- group, 30% in CPC+/- group and 12% in CPC+/+ or -/+ group ( p=0.018). At a median follow-up of 58 months from ASCT, the median progression-free survival (PFS) from transplant in the 3 respective groups was 30, 24 and 14 months and the 5-year overall survival (OS) rates were 83%, 70% and 43% ( p<0.001 for both comparisons). On a multivariate analysis, using CPC-/- group as the comparator, PFS and OS was significantly inferior in CPC+/- (RR 1.6; p=0.020 and RR 2.7; p=0.008 for PFS and OS respectively) and CPC +/+ or -/+ groups (RR 2.9; p<0.001 and RR 5.8; p<0.001 for PFS and OS respectively). Conclusions: Clonal CPCs are detectable in more than 50% of newly diagnosed MM patients undergoing upfront ASCT. Monitoring for CPCs before initiation of induction therapy and before ASCT by 6-color flow cytometry is highly predictive of outcome in NDMM and should be incorporated into prospective clinical trials." @default.
• W2890720744 created "2018-09-27" @default.
• W2890720744 creator A5001453763 @default.
• W2890720744 creator A5002248011 @default.
• W2890720744 creator A5004220089 @default.
• W2890720744 creator A5007747233 @default.
• W2890720744 creator A5012403700 @default.
• W2890720744 creator A5016853434 @default.
• W2890720744 creator A5020885025 @default.
• W2890720744 creator A5026574827 @default.
• W2890720744 creator A5033220547 @default.
• W2890720744 creator A5072502164 @default.
• W2890720744 creator A5076611748 @default.
• W2890720744 creator A5077686486 @default.
• W2890720744 creator A5084606047 @default.
• W2890720744 date "2017-05-20" @default.
• W2890720744 modified "2023-09-23" @default.
• W2890720744 title "Prognostic impact of kinetics of circulating plasma cells before and after induction therapy in newly diagnosed multiple myeloma patients undergoing early transplantation." @default.
• W2890720744 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.8020" @default.
• W2890720744 hasPublicationYear "2017" @default.
• W2890720744 type Work @default.
• W2890720744 sameAs 2890720744 @default.
• W2890720744 citedByCount "0" @default.
• W2890720744 crossrefType "journal-article" @default.
• W2890720744 hasAuthorship W2890720744A5001453763 @default.
• W2890720744 hasAuthorship W2890720744A5002248011 @default.
• W2890720744 hasAuthorship W2890720744A5004220089 @default.
• W2890720744 hasAuthorship W2890720744A5007747233 @default.
• W2890720744 hasAuthorship W2890720744A5012403700 @default.
• W2890720744 hasAuthorship W2890720744A5016853434 @default.
• W2890720744 hasAuthorship W2890720744A5020885025 @default.
• W2890720744 hasAuthorship W2890720744A5026574827 @default.
• W2890720744 hasAuthorship W2890720744A5033220547 @default.
• W2890720744 hasAuthorship W2890720744A5072502164 @default.
• W2890720744 hasAuthorship W2890720744A5076611748 @default.
• W2890720744 hasAuthorship W2890720744A5077686486 @default.
• W2890720744 hasAuthorship W2890720744A5084606047 @default.
• W2890720744 hasConcept C126322002 @default.
• W2890720744 hasConcept C141071460 @default.
• W2890720744 hasConcept C143998085 @default.
• W2890720744 hasConcept C203014093 @default.
• W2890720744 hasConcept C2776364478 @default.
• W2890720744 hasConcept C2776694085 @default.
• W2890720744 hasConcept C2911091166 @default.
• W2890720744 hasConcept C2991767035 @default.
• W2890720744 hasConcept C71924100 @default.
• W2890720744 hasConceptScore W2890720744C126322002 @default.
• W2890720744 hasConceptScore W2890720744C141071460 @default.
• W2890720744 hasConceptScore W2890720744C143998085 @default.
• W2890720744 hasConceptScore W2890720744C203014093 @default.
• W2890720744 hasConceptScore W2890720744C2776364478 @default.
• W2890720744 hasConceptScore W2890720744C2776694085 @default.
• W2890720744 hasConceptScore W2890720744C2911091166 @default.
• W2890720744 hasConceptScore W2890720744C2991767035 @default.
• W2890720744 hasConceptScore W2890720744C71924100 @default.
• W2890720744 hasLocation W28907207441 @default.
• W2890720744 hasOpenAccess W2890720744 @default.
• W2890720744 hasPrimaryLocation W28907207441 @default.
• W2890720744 hasRelatedWork W1927336306 @default.
• W2890720744 hasRelatedWork W2025105196 @default.
• W2890720744 hasRelatedWork W2030079782 @default.
• W2890720744 hasRelatedWork W2073735345 @default.
• W2890720744 hasRelatedWork W2090267595 @default.
• W2890720744 hasRelatedWork W2145132321 @default.
• W2890720744 hasRelatedWork W2222753116 @default.
• W2890720744 hasRelatedWork W2263985446 @default.
• W2890720744 hasRelatedWork W2364134110 @default.
• W2890720744 hasRelatedWork W2422152087 @default.
• W2890720744 hasRelatedWork W2430457603 @default.
• W2890720744 hasRelatedWork W2439009223 @default.
• W2890720744 hasRelatedWork W2467410221 @default.
• W2890720744 hasRelatedWork W2593444628 @default.
• W2890720744 hasRelatedWork W2922219316 @default.
• W2890720744 hasRelatedWork W2970064410 @default.
• W2890720744 hasRelatedWork W2994685585 @default.
• W2890720744 hasRelatedWork W3011340794 @default.
• W2890720744 hasRelatedWork W3025242810 @default.
• W2890720744 hasRelatedWork W3042630715 @default.
• W2890720744 isParatext "false" @default.
• W2890720744 isRetracted "false" @default.
• W2890720744 magId "2890720744" @default.
• W2890720744 workType "article" @default.