FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890721902> ?p ?o ?g. }

• W2890721902 endingPage "8657" @default.
• W2890721902 startingPage "8639" @default.
• W2890721902 abstract "The synthesis of potent metabolically stable endocannabinoids is challenging. Here we report a chiral arachidonoyl ethanolamide (AEA) analogue, namely, (13S,1′R)-dimethylanandamide (AMG315, 3a), a high affinity ligand for the CB1 receptor (Ki of 7.8 ± 1.4 nM) that behaves as a potent CB1 agonist in vitro (EC50 = 0.6 ± 0.2 nM). (13S,1′R)-dimethylanandamide is the first potent AEA analogue with significant stability for all endocannabinoid hydrolyzing enzymes as well as the oxidative enzymes COX-2. When tested in vivo using the CFA-induced inflammatory pain model, 3a behaved as a more potent analgesic when compared to endogenous AEA or its hydrolytically stable analogue AM356. This novel analogue will serve as a very useful endocannabinoid probe." @default.
• W2890721902 created "2018-09-27" @default.
• W2890721902 creator A5000540926 @default.
• W2890721902 creator A5004342431 @default.
• W2890721902 creator A5012489562 @default.
• W2890721902 creator A5025755881 @default.
• W2890721902 creator A5028196738 @default.
• W2890721902 creator A5035967912 @default.
• W2890721902 creator A5040075356 @default.
• W2890721902 creator A5046660337 @default.
• W2890721902 creator A5052795893 @default.
• W2890721902 creator A5060199985 @default.
• W2890721902 creator A5061917163 @default.
• W2890721902 creator A5067521970 @default.
• W2890721902 creator A5068361479 @default.
• W2890721902 creator A5071278866 @default.
• W2890721902 creator A5072446750 @default.
• W2890721902 creator A5075195709 @default.
• W2890721902 creator A5081335529 @default.
• W2890721902 creator A5081706069 @default.
• W2890721902 creator A5083835532 @default.
• W2890721902 creator A5084465450 @default.
• W2890721902 creator A5084622430 @default.
• W2890721902 creator A5089031929 @default.
• W2890721902 creator A5089461409 @default.
• W2890721902 date "2018-09-10" @default.
• W2890721902 modified "2023-10-17" @default.
• W2890721902 title "(<i>R</i>)-<i>N</i>-(1-Methyl-2-hydroxyethyl)-13-(<i>S</i>)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes" @default.
• W2890721902 cites W1886084954 @default.
• W2890721902 cites W1976465280 @default.
• W2890721902 cites W1977912349 @default.
• W2890721902 cites W1981629743 @default.
• W2890721902 cites W1984563050 @default.
• W2890721902 cites W1985164787 @default.
• W2890721902 cites W2001609721 @default.
• W2890721902 cites W2005525544 @default.
• W2890721902 cites W2028259044 @default.
• W2890721902 cites W2028497968 @default.
• W2890721902 cites W2031888213 @default.
• W2890721902 cites W2036390316 @default.
• W2890721902 cites W2041104179 @default.
• W2890721902 cites W2046397438 @default.
• W2890721902 cites W2048356291 @default.
• W2890721902 cites W2049754046 @default.
• W2890721902 cites W2051621327 @default.
• W2890721902 cites W2053648339 @default.
• W2890721902 cites W2056037589 @default.
• W2890721902 cites W2059539544 @default.
• W2890721902 cites W2067592086 @default.
• W2890721902 cites W2072089531 @default.
• W2890721902 cites W2074631079 @default.
• W2890721902 cites W2077117815 @default.
• W2890721902 cites W2085596556 @default.
• W2890721902 cites W2088995789 @default.
• W2890721902 cites W2093775315 @default.
• W2890721902 cites W2100840632 @default.
• W2890721902 cites W2129968939 @default.
• W2890721902 cites W2141821654 @default.
• W2890721902 cites W2147017754 @default.
• W2890721902 cites W2153308867 @default.
• W2890721902 cites W2169480655 @default.
• W2890721902 cites W2313420814 @default.
• W2890721902 cites W2326460726 @default.
• W2890721902 cites W24381337 @default.
• W2890721902 cites W2472242733 @default.
• W2890721902 cites W2533852048 @default.
• W2890721902 cites W2624151290 @default.
• W2890721902 cites W2727341066 @default.
• W2890721902 cites W2729726531 @default.
• W2890721902 cites W2952210817 @default.
• W2890721902 cites W1997547007 @default.
• W2890721902 doi "https://doi.org/10.1021/acs.jmedchem.8b00611" @default.
• W2890721902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30196704" @default.
• W2890721902 hasPublicationYear "2018" @default.
• W2890721902 type Work @default.
• W2890721902 sameAs 2890721902 @default.
• W2890721902 citedByCount "12" @default.
• W2890721902 countsByYear W28907219022019 @default.
• W2890721902 countsByYear W28907219022020 @default.
• W2890721902 countsByYear W28907219022022 @default.
• W2890721902 countsByYear W28907219022023 @default.
• W2890721902 crossrefType "journal-article" @default.
• W2890721902 hasAuthorship W2890721902A5000540926 @default.
• W2890721902 hasAuthorship W2890721902A5004342431 @default.
• W2890721902 hasAuthorship W2890721902A5012489562 @default.
• W2890721902 hasAuthorship W2890721902A5025755881 @default.
• W2890721902 hasAuthorship W2890721902A5028196738 @default.
• W2890721902 hasAuthorship W2890721902A5035967912 @default.
• W2890721902 hasAuthorship W2890721902A5040075356 @default.
• W2890721902 hasAuthorship W2890721902A5046660337 @default.
• W2890721902 hasAuthorship W2890721902A5052795893 @default.
• W2890721902 hasAuthorship W2890721902A5060199985 @default.
• W2890721902 hasAuthorship W2890721902A5061917163 @default.
• W2890721902 hasAuthorship W2890721902A5067521970 @default.
• W2890721902 hasAuthorship W2890721902A5068361479 @default.
• W2890721902 hasAuthorship W2890721902A5071278866 @default.
• W2890721902 hasAuthorship W2890721902A5072446750 @default.
• W2890721902 hasAuthorship W2890721902A5075195709 @default.

• next