FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890723626> ?p ?o ?g. }

• W2890723626 endingPage "1751" @default.
• W2890723626 startingPage "1742" @default.
• W2890723626 abstract "To evaluate the safety of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor alirocumab according to diabetes mellitus status.Safety data from 14 trials (8-104-week durations) were analysed by treatment (alirocumab or placebo/ezetimibe control) and diabetes status (yes/no, defined by medical history). Adverse event data were assessed using descriptive statistics and Cox models.Of the 5234 trial participants, 1554 (29.7%) had diabetes. Overall, treatment-emergent adverse events were similar in the alirocumab and control groups, except for more frequent local injection site reactions with alirocumab. Fewer people with diabetes experienced local injection site reactions [alirocumab, 3.5%, control, 2.9%; hazard ratio 1.24 (95% CI 0.68-2.25)] than those without diabetes [alirocumab, 7.5%; control, 4.9%; hazard ratio 1.51 (95% CI 1.13-2.01)]. Those with diabetes reported a greater number of serious adverse events (alirocumab, 19.4%; control, 19.7%) than those without diabetes (alirocumab, 14.5%; control, 13.5%). In people with diabetes, major adverse cardiac events occurred in 2.7% of alirocumab-treated people [control, 3.3%; hazard ratio 0.74 (95% CI 0.41-1.35)]; in those without diabetes, 1.8% of alirocumab-treated people had major adverse cardiac events [control, 1.7%; hazard ratio 0.95 (95% CI 0.56-1.62)]. Overall, no increase in HbA1c or fasting plasma glucose vs control treatment groups was observed, regardless of diabetes status.This pooled analysis across 14 trials demonstrated similar safety for alirocumab vs control treatment, irrespective of diabetes status, except for more frequent local injection site reactions with alirocumab. People with diabetes reported fewer local injection site reactions than those without diabetes." @default.
• W2890723626 created "2018-09-27" @default.
• W2890723626 creator A5021274752 @default.
• W2890723626 creator A5061677162 @default.
• W2890723626 creator A5064108235 @default.
• W2890723626 creator A5080099404 @default.
• W2890723626 creator A5080414941 @default.
• W2890723626 creator A5080948815 @default.
• W2890723626 creator A5083408711 @default.
• W2890723626 creator A5091215222 @default.
• W2890723626 date "2018-10-09" @default.
• W2890723626 modified "2023-10-17" @default.
• W2890723626 title "Alirocumab safety in people with and without diabetes mellitus: pooled data from 14 ODYSSEY trials" @default.
• W2890723626 cites W1423581981 @default.
• W2890723626 cites W1962272706 @default.
• W2890723626 cites W1985747185 @default.
• W2890723626 cites W2001328643 @default.
• W2890723626 cites W2014320894 @default.
• W2890723626 cites W2014759828 @default.
• W2890723626 cites W2096075279 @default.
• W2890723626 cites W2101702589 @default.
• W2890723626 cites W2128030263 @default.
• W2890723626 cites W2141898196 @default.
• W2890723626 cites W2148577580 @default.
• W2890723626 cites W2166934777 @default.
• W2890723626 cites W2218353190 @default.
• W2890723626 cites W2266600614 @default.
• W2890723626 cites W2337214440 @default.
• W2890723626 cites W2486690983 @default.
• W2890723626 cites W2519905430 @default.
• W2890723626 cites W2520424058 @default.
• W2890723626 cites W2522643247 @default.
• W2890723626 cites W2557654447 @default.
• W2890723626 cites W2582372330 @default.
• W2890723626 cites W2588974371 @default.
• W2890723626 cites W2740734217 @default.
• W2890723626 cites W2743957775 @default.
• W2890723626 cites W2754562397 @default.
• W2890723626 cites W2756174617 @default.
• W2890723626 cites W2785958895 @default.
• W2890723626 cites W2787959738 @default.
• W2890723626 cites W2803816352 @default.
• W2890723626 cites W2890723626 @default.
• W2890723626 doi "https://doi.org/10.1111/dme.13817" @default.
• W2890723626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6585811" @default.
• W2890723626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30183102" @default.
• W2890723626 hasPublicationYear "2018" @default.
• W2890723626 type Work @default.
• W2890723626 sameAs 2890723626 @default.
• W2890723626 citedByCount "17" @default.
• W2890723626 countsByYear W28907236262019 @default.
• W2890723626 countsByYear W28907236262020 @default.
• W2890723626 countsByYear W28907236262021 @default.
• W2890723626 countsByYear W28907236262022 @default.
• W2890723626 countsByYear W28907236262023 @default.
• W2890723626 crossrefType "journal-article" @default.
• W2890723626 hasAuthorship W2890723626A5021274752 @default.
• W2890723626 hasAuthorship W2890723626A5061677162 @default.
• W2890723626 hasAuthorship W2890723626A5064108235 @default.
• W2890723626 hasAuthorship W2890723626A5080099404 @default.
• W2890723626 hasAuthorship W2890723626A5080414941 @default.
• W2890723626 hasAuthorship W2890723626A5080948815 @default.
• W2890723626 hasAuthorship W2890723626A5083408711 @default.
• W2890723626 hasAuthorship W2890723626A5091215222 @default.
• W2890723626 hasBestOaLocation W28907236261 @default.
• W2890723626 hasConcept C126322002 @default.
• W2890723626 hasConcept C134018914 @default.
• W2890723626 hasConcept C197934379 @default.
• W2890723626 hasConcept C207103383 @default.
• W2890723626 hasConcept C2778163477 @default.
• W2890723626 hasConcept C2780072125 @default.
• W2890723626 hasConcept C2780745583 @default.
• W2890723626 hasConcept C2780902209 @default.
• W2890723626 hasConcept C2780948078 @default.
• W2890723626 hasConcept C43554185 @default.
• W2890723626 hasConcept C44249647 @default.
• W2890723626 hasConcept C555293320 @default.
• W2890723626 hasConcept C62746215 @default.
• W2890723626 hasConcept C71924100 @default.
• W2890723626 hasConceptScore W2890723626C126322002 @default.
• W2890723626 hasConceptScore W2890723626C134018914 @default.
• W2890723626 hasConceptScore W2890723626C197934379 @default.
• W2890723626 hasConceptScore W2890723626C207103383 @default.
• W2890723626 hasConceptScore W2890723626C2778163477 @default.
• W2890723626 hasConceptScore W2890723626C2780072125 @default.
• W2890723626 hasConceptScore W2890723626C2780745583 @default.
• W2890723626 hasConceptScore W2890723626C2780902209 @default.
• W2890723626 hasConceptScore W2890723626C2780948078 @default.
• W2890723626 hasConceptScore W2890723626C43554185 @default.
• W2890723626 hasConceptScore W2890723626C44249647 @default.
• W2890723626 hasConceptScore W2890723626C555293320 @default.
• W2890723626 hasConceptScore W2890723626C62746215 @default.
• W2890723626 hasConceptScore W2890723626C71924100 @default.
• W2890723626 hasFunder F4320307781 @default.
• W2890723626 hasFunder F4320311600 @default.
• W2890723626 hasIssue "12" @default.
• W2890723626 hasLocation W28907236261 @default.
• W2890723626 hasLocation W28907236262 @default.

• next