Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890725618> ?p ?o ?g. }
- W2890725618 endingPage "76" @default.
- W2890725618 startingPage "64" @default.
- W2890725618 abstract "Histone H2B lysine 123 mono-ubiquitination (H2Bub1), catalyzed by Rad6 and Bre1 in Saccharomyces cerevisiae, modulates chromatin structure and affects diverse cellular functions. H2Bub1 plays roles in telomeric silencing and telomere replication. Here, we have explored a novel role of H2Bub1 in telomere protection at uncapped telomeres in yku70Δ and cdc13-1 cells. Deletion of RAD6 or BRE1, or mutation of H2BK123R enhances the temperature sensitivity of both yku70Δ and cdc13-1 telomere capping mutants. Consistently, BRE1 deletion increases accumulation of telomeric single-stranded DNA (ssDNA) in yku70Δ and cdc13-1 cells, and EXO1 deletion improves the growth of yku70Δ bre1Δ and cdc13-1 bre1Δ cells and decreases ssDNA accumulation. Additionally, deletion of BRE1 exacerbates the rate of entry into senescence of yku70Δ mre11Δ cells with telomere defects, and increases the recombination of subtelomeric Y' element that is required for telomere maintenance and survivor generation. Furthermore, Exo1 contributes to the abrupt senescence of yku70Δ mre11Δ bre1Δ cells, and Rad51 is essential for Y' recombination to generate survivors. Finally, deletion of BRE1 or mutation of H2BK123R results in nucleosome instability at subtelomeric regions. Collectively, this study provides a mechanistic link between H2Bub1-mediated chromatin structure and telomere protection after telomere uncapping." @default.
- W2890725618 created "2018-09-27" @default.
- W2890725618 creator A5001877165 @default.
- W2890725618 creator A5002285645 @default.
- W2890725618 creator A5020879747 @default.
- W2890725618 creator A5027835055 @default.
- W2890725618 creator A5045550226 @default.
- W2890725618 creator A5056088702 @default.
- W2890725618 date "2018-12-01" @default.
- W2890725618 modified "2023-10-12" @default.
- W2890725618 title "Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae" @default.
- W2890725618 cites W1888032283 @default.
- W2890725618 cites W1963996414 @default.
- W2890725618 cites W1964071811 @default.
- W2890725618 cites W1965541518 @default.
- W2890725618 cites W1966072209 @default.
- W2890725618 cites W1970891016 @default.
- W2890725618 cites W1971358935 @default.
- W2890725618 cites W1977188840 @default.
- W2890725618 cites W1979164620 @default.
- W2890725618 cites W1982619023 @default.
- W2890725618 cites W1988669405 @default.
- W2890725618 cites W1992350296 @default.
- W2890725618 cites W1993746844 @default.
- W2890725618 cites W1996749761 @default.
- W2890725618 cites W1998232368 @default.
- W2890725618 cites W2006001474 @default.
- W2890725618 cites W2031936092 @default.
- W2890725618 cites W2035931727 @default.
- W2890725618 cites W2036479240 @default.
- W2890725618 cites W2037093097 @default.
- W2890725618 cites W2040080051 @default.
- W2890725618 cites W2043745412 @default.
- W2890725618 cites W2045500168 @default.
- W2890725618 cites W2046909262 @default.
- W2890725618 cites W2061091865 @default.
- W2890725618 cites W2064774611 @default.
- W2890725618 cites W2065612395 @default.
- W2890725618 cites W2070250072 @default.
- W2890725618 cites W2070650765 @default.
- W2890725618 cites W2080783893 @default.
- W2890725618 cites W2085494245 @default.
- W2890725618 cites W2088390649 @default.
- W2890725618 cites W2092131372 @default.
- W2890725618 cites W2092144038 @default.
- W2890725618 cites W2094119502 @default.
- W2890725618 cites W2095588806 @default.
- W2890725618 cites W2101751768 @default.
- W2890725618 cites W2113872491 @default.
- W2890725618 cites W2116463355 @default.
- W2890725618 cites W2119410736 @default.
- W2890725618 cites W2122658576 @default.
- W2890725618 cites W2124242199 @default.
- W2890725618 cites W2125219377 @default.
- W2890725618 cites W2130525093 @default.
- W2890725618 cites W2133063603 @default.
- W2890725618 cites W2133233872 @default.
- W2890725618 cites W2139028412 @default.
- W2890725618 cites W2140168282 @default.
- W2890725618 cites W2141288561 @default.
- W2890725618 cites W2144157991 @default.
- W2890725618 cites W2150490516 @default.
- W2890725618 cites W2150788604 @default.
- W2890725618 cites W2151189492 @default.
- W2890725618 cites W2151277324 @default.
- W2890725618 cites W2152508214 @default.
- W2890725618 cites W2154387979 @default.
- W2890725618 cites W2156315323 @default.
- W2890725618 cites W2162261435 @default.
- W2890725618 cites W2169333620 @default.
- W2890725618 cites W2169898508 @default.
- W2890725618 cites W2337782367 @default.
- W2890725618 cites W2409242545 @default.
- W2890725618 cites W2587710516 @default.
- W2890725618 cites W2592850216 @default.
- W2890725618 cites W2780663388 @default.
- W2890725618 doi "https://doi.org/10.1016/j.dnarep.2018.09.007" @default.
- W2890725618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254011" @default.
- W2890725618 hasPublicationYear "2018" @default.
- W2890725618 type Work @default.
- W2890725618 sameAs 2890725618 @default.
- W2890725618 citedByCount "5" @default.
- W2890725618 countsByYear W28907256182019 @default.
- W2890725618 countsByYear W28907256182020 @default.
- W2890725618 countsByYear W28907256182021 @default.
- W2890725618 countsByYear W28907256182022 @default.
- W2890725618 crossrefType "journal-article" @default.
- W2890725618 hasAuthorship W2890725618A5001877165 @default.
- W2890725618 hasAuthorship W2890725618A5002285645 @default.
- W2890725618 hasAuthorship W2890725618A5020879747 @default.
- W2890725618 hasAuthorship W2890725618A5027835055 @default.
- W2890725618 hasAuthorship W2890725618A5045550226 @default.
- W2890725618 hasAuthorship W2890725618A5056088702 @default.
- W2890725618 hasConcept C102744134 @default.
- W2890725618 hasConcept C104317684 @default.
- W2890725618 hasConcept C134935766 @default.
- W2890725618 hasConcept C143425029 @default.
- W2890725618 hasConcept C153911025 @default.