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• W2890727767 abstract "Abstract Our understanding of eukaryotic gene regulation is limited by the complexity of protein-DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introduced CUT&RUN, an antibody-targeted nuclease-cleavage method that profiles DNA-binding proteins, histones and chromatin modifying proteins in situ with exceptional sensitivity and resolution. Here we describe an automated CUT&RUN platform and apply it to characterize the chromatin landscapes of human cell lines. We find that CUT&RUN profiles of histone modifications crisply demarcate active and repressed chromatin regions, and we develop a continuous metric to identify cell-type specific promoter and enhancer activities. We test the ability of automated CUT&RUN to profile frozen tumor samples, and find that our method readily distinguishes two diffuse midline gliomas by their subtype-specific gene expression programs. The easy, cost-effective workflow makes automated CUT&RUN an attractive tool for high-throughput characterization of cell types and patient samples." @default.
• W2890727767 created "2018-09-27" @default.
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• W2890727767 date "2018-09-16" @default.
• W2890727767 modified "2023-10-14" @default.
• W2890727767 title "Automated in situ profiling of chromatin modifications resolves cell types and gene regulatory programs" @default.
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• W2890727767 doi "https://doi.org/10.1101/418681" @default.
• W2890727767 hasPublicationYear "2018" @default.
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