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- W2890728023 abstract "The specific contribution of each bacterial species within a complex microbiota to the regulation of host lipid metabolism remains largely unknown. Using two model commensal microorganisms, L. paracasei and E. coli , we demonstrated that both bacterial species impacted host lipid metabolism in a diet-dependent manner and, notably, that L. paracasei -colonized mice but not E. coli -colonized mice resisted high-fat-diet-induced body weight gain. In addition, we set up cellular models of fatty acid absorption and secretion by enterocytes cocultured with bacteria and showed that, in vitro , both L. paracasei and E. coli inhibited lipid secretion, through increased intracellular fat storage and enhanced lipid catabolism, respectively." @default.
- W2890728023 created "2018-09-27" @default.
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- W2890728023 date "2018-11-07" @default.
- W2890728023 modified "2023-10-14" @default.
- W2890728023 title "Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals <i>Lactobacillus paracasei</i> and <i>Escherichia coli</i>" @default.
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- W2890728023 doi "https://doi.org/10.1128/mbio.01493-18" @default.
- W2890728023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6123438" @default.
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