Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890735529> ?p ?o ?g. }
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- W2890735529 abstract "Toll-like Receptor 4 (TLR4) agonists have had a long journey in the field of cancer immunotherapy. Nevertheless, despite the remarkable number of the TLR4 ligands that have gone through various preclinical and clinical stages, only two (Bacillus Calmette-Guérin (BCG) and monophosphoryl lipid A (MPLA)) have hitherto obtained the FDA approval for clinical application in cancer treatment. This paper provides a comprehensive review of the TLR4 agonists' journey as cancer active immunotherapeutics. Following a brief discussion of the rationale behind the use of TLR ligands in cancer immunotherapy, we will initially focus on the forerunner of the TLR4 agonists, bacterial lipopolysaccharide (LPS). Within this context, the potentials and shortcomings of immunotherapy with this agent will be addressed, the strategies that have been devised to enhance the associated therapeutic outcome will be discussed, and the consequent achievements and shortcomings will be summarized. Subsequently, further and perhaps less well-known, molecular, bacterial, and viral TLR4 agonists with potential for cancer immunotherapy will be introduced, and if present, the outcome of the preclinical and clinical investigations of these agents will be reviewed. Finally, a look will be cast upon the promising souvenirs of the relatively new arena of nanotechnology, where TLR4 activating nanoparticulate systems will be proposed as potential candidates for the future development of this field." @default.
- W2890735529 created "2018-09-27" @default.
- W2890735529 creator A5006870722 @default.
- W2890735529 creator A5087419324 @default.
- W2890735529 date "2018-09-18" @default.
- W2890735529 modified "2023-10-17" @default.
- W2890735529 title "TLR4-Based Immunotherapeutics in Cancer: A Review of the Achievements and Shortcomings" @default.
- W2890735529 cites W123858806 @default.
- W2890735529 cites W125326105 @default.
- W2890735529 cites W1488327245 @default.
- W2890735529 cites W1499834365 @default.
- W2890735529 cites W1545200717 @default.
- W2890735529 cites W1568959328 @default.
- W2890735529 cites W1576543020 @default.
- W2890735529 cites W1698171640 @default.
- W2890735529 cites W1740615695 @default.
- W2890735529 cites W1760966156 @default.
- W2890735529 cites W1866923511 @default.
- W2890735529 cites W1940904684 @default.
- W2890735529 cites W1966061460 @default.
- W2890735529 cites W1966387946 @default.
- W2890735529 cites W1966649995 @default.
- W2890735529 cites W1968006592 @default.
- W2890735529 cites W1968955362 @default.
- W2890735529 cites W1974498683 @default.
- W2890735529 cites W1975687193 @default.
- W2890735529 cites W1975856526 @default.
- W2890735529 cites W1977103492 @default.
- W2890735529 cites W1977957999 @default.
- W2890735529 cites W1979096813 @default.
- W2890735529 cites W1979981806 @default.
- W2890735529 cites W1981054482 @default.
- W2890735529 cites W1981087308 @default.
- W2890735529 cites W1982061062 @default.
- W2890735529 cites W1982334199 @default.
- W2890735529 cites W1983111017 @default.
- W2890735529 cites W1983341848 @default.
- W2890735529 cites W1983882689 @default.
- W2890735529 cites W1984744520 @default.
- W2890735529 cites W1985603041 @default.
- W2890735529 cites W1985803217 @default.
- W2890735529 cites W1986189885 @default.
- W2890735529 cites W1987277679 @default.
- W2890735529 cites W1987420336 @default.
- W2890735529 cites W1988102572 @default.
- W2890735529 cites W1991731944 @default.
- W2890735529 cites W1992685641 @default.
- W2890735529 cites W1994521826 @default.
- W2890735529 cites W1996652335 @default.
- W2890735529 cites W1997390346 @default.
- W2890735529 cites W1998912113 @default.
- W2890735529 cites W1999070120 @default.
- W2890735529 cites W2000052279 @default.
- W2890735529 cites W2000755721 @default.
- W2890735529 cites W2000818889 @default.
- W2890735529 cites W2001891176 @default.
- W2890735529 cites W2003064885 @default.
- W2890735529 cites W2004058416 @default.
- W2890735529 cites W2004791006 @default.
- W2890735529 cites W2005367152 @default.
- W2890735529 cites W2005392080 @default.
- W2890735529 cites W2005757619 @default.
- W2890735529 cites W2014902970 @default.
- W2890735529 cites W2016163671 @default.
- W2890735529 cites W2016806021 @default.
- W2890735529 cites W2016991044 @default.
- W2890735529 cites W2018322803 @default.
- W2890735529 cites W2019479596 @default.
- W2890735529 cites W2020295320 @default.
- W2890735529 cites W2020662227 @default.
- W2890735529 cites W2021582993 @default.
- W2890735529 cites W2021891258 @default.
- W2890735529 cites W2022215519 @default.
- W2890735529 cites W2023557351 @default.
- W2890735529 cites W2023797723 @default.
- W2890735529 cites W2026566342 @default.
- W2890735529 cites W2027047709 @default.
- W2890735529 cites W2027782959 @default.
- W2890735529 cites W2029097673 @default.
- W2890735529 cites W2029624351 @default.
- W2890735529 cites W2030883091 @default.
- W2890735529 cites W2031196319 @default.
- W2890735529 cites W2033837674 @default.
- W2890735529 cites W2034394424 @default.
- W2890735529 cites W2037794305 @default.
- W2890735529 cites W2037909222 @default.
- W2890735529 cites W2039529032 @default.
- W2890735529 cites W2040427634 @default.
- W2890735529 cites W2040488764 @default.
- W2890735529 cites W2046223700 @default.
- W2890735529 cites W2046527429 @default.
- W2890735529 cites W2046671679 @default.
- W2890735529 cites W2046931618 @default.
- W2890735529 cites W2047573521 @default.
- W2890735529 cites W2048214675 @default.
- W2890735529 cites W2051133984 @default.
- W2890735529 cites W2051940924 @default.
- W2890735529 cites W2051993223 @default.