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- W2890736695 abstract "Objective: To assess the impact of change in depressive symptoms on quality of life in Alzheimer disease Background: Depression has been consistently associated with both self- and caregiver-rated quality of life (QoL) in Alzheimer disease (AD) in cross-sectional studies; however longitudinal data on the relationship between these factors is lacking. Design/Methods: Data were analyzed from 156 persons with possible or probable AD from the Depression in Alzheimer Disease study of the California Alzheimer Disease Centers (CADC). Quality of life at baseline and 3 month follow up was measured using the self- and caregiver-rated QoL-AD measures. Depression was measured using the 30-item Geriatric Depression Scale (GDS). Pearson correlations were calculated for baseline values as well as change over time. Results: Baseline self-rated GDS scores were negatively correlated with self-rated QoL-AD scores (r=−0.60, p Conclusions: Depression is an important mediator of self-reported QoL in AD; this is in contrast to other behavioral symptoms or functional status that have been previously shown to correlate with caregiver-rated but not self-rated QoL. Caregiver perception of patient depressive symptoms influences caregiver rating of patient QoL. Disclosure: Dr. Joe has nothing to disclose. Dr. Segal-Gidan has nothing to disclose. Dr. Schneider has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Takeda (adjudication committee), Merck (DSMB). Consulting: AC Immune, Avraham, Axovant, Boehringer Ingelheim, Cognition, Insys, Kyowa Kirin, Neurim, Tau Rx, vTv. Dr. Schneider has received personal compensation in an editorial capacity for Alzheimer & Dementia: Translational Research and Clinical Intervention. Dr. Schneider has received research support from Yes, Biogen, Genentech, Lilly, Novartis. Dr. Chui has nothing to disclose. Dr. Ringman has nothing to disclose." @default.
- W2890736695 created "2018-09-27" @default.
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- W2890736695 date "2018-04-10" @default.
- W2890736695 modified "2023-09-26" @default.
- W2890736695 title "Changes in Depression Severity Correlate with Quality of Life in Alzheimer Disease: a Longitudinal Study (P6.189)" @default.
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