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- W2890737189 abstract "Aberrant proliferation and migration of airway smooth muscle cells (ASMCs) contribute to the pathogenesis of airway remodeling during asthma development. Here, the potential function of microRNA-217 (miR-217) on the cell proliferation and migration of TGF-β1-induced ASMCs and the involved mechanisms were investigated in this study. We found that miR-217 expression was apparently downregulated in a time and dose dependent characteristic in ASMCs exposed to transforming growth factor-β (TGF-β1) stimulation. Overexpression of miR-217 significantly inhibited TGF-β1-induced proliferation, migration, extracellular matrix (ECM) deposition, but promoted apoptosis in ASMCs, whereas, miR-217 inhibitor showed an opposed effect. Bioinformatics analyses revealed that the 3'-untranslated region (UTR) of ZEB1 was a potential target for miR-217, which was further confirmed by luciferase activity, qRT-PCR and western blot assay. In addition, rescue experiment also displayed that restoration of ZEB1 expression partially abrogated the inhibitory effect of miR-217 on TGF-β1-induced proliferation and migration in ASMCs. By chromatin immunoprecipitation (ChIP) assay, we further confirmed that the binding of ZEB1 to the fibronectin promoter in TGF-β1-treated ASMCs was reduced by miR-217 overexpression. Therefore, our findings suggested the potential protective role of miR-217 on the attenuation of cell proliferation and migration was through targeting ZEB1 in TGF-β1-stimulated ASMCs." @default.
- W2890737189 created "2018-09-27" @default.
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- W2890737189 date "2018-12-01" @default.
- W2890737189 modified "2023-10-16" @default.
- W2890737189 title "RETRACTED: miR-217 represses TGF-β1-induced airway smooth muscle cell proliferation and migration through targeting ZEB1" @default.
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- W2890737189 doi "https://doi.org/10.1016/j.biopha.2018.09.030" @default.
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