Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890741047> ?p ?o ?g. }
- W2890741047 endingPage "55" @default.
- W2890741047 startingPage "41" @default.
- W2890741047 abstract "The uncoupling protein (UCP1) is a proton (H+) transporter in the mitochondrial inner membrane. By dissipating the electrochemical H+ gradient, UCP1 uncouples respiration from ATP synthesis, which drives an increase in substrate oxidation via the TCA cycle flux that generates more heat. The mitochondrial uncoupling-mediated non-shivering thermogenesis in brown adipose tissue is vital primarily to mammals, such as rodents and new-born humans, but more recently additional functions in adult humans have been described. UCP1 is regulated by β-adrenergic receptors through the sympathetic nervous system and at the molecular activity level by nucleotides and fatty acid to meet thermogenesis needs. The discovery of novel UCP homologs has greatly contributed to the understanding of human diseases, such as obesity and diabetes. In this article, we review the progress made towards the molecular mechanism and function of the UCPs, in particular focusing on the influential contributions from Martin Klingenberg's laboratory. Because all members of the UCP family are potentially promising drug targets, we also present and discuss possible approaches and methods for UCP-related drug discovery." @default.
- W2890741047 created "2018-09-27" @default.
- W2890741047 creator A5018513639 @default.
- W2890741047 creator A5026714835 @default.
- W2890741047 creator A5028929620 @default.
- W2890741047 creator A5033659100 @default.
- W2890741047 creator A5035697355 @default.
- W2890741047 creator A5049189701 @default.
- W2890741047 creator A5053018564 @default.
- W2890741047 creator A5076597499 @default.
- W2890741047 creator A5091834634 @default.
- W2890741047 date "2018-11-01" @default.
- W2890741047 modified "2023-10-01" @default.
- W2890741047 title "Uncoupling proteins: Martin Klingenberg's contributions for 40 years" @default.
- W2890741047 cites W1133537799 @default.
- W2890741047 cites W1174194052 @default.
- W2890741047 cites W1203395875 @default.
- W2890741047 cites W124504601 @default.
- W2890741047 cites W125432973 @default.
- W2890741047 cites W1424645202 @default.
- W2890741047 cites W1511403368 @default.
- W2890741047 cites W1519247927 @default.
- W2890741047 cites W1522261519 @default.
- W2890741047 cites W1530102586 @default.
- W2890741047 cites W1550000221 @default.
- W2890741047 cites W1557140781 @default.
- W2890741047 cites W1560402341 @default.
- W2890741047 cites W1569566110 @default.
- W2890741047 cites W1583629732 @default.
- W2890741047 cites W1610607546 @default.
- W2890741047 cites W1616682748 @default.
- W2890741047 cites W1964004368 @default.
- W2890741047 cites W1964126982 @default.
- W2890741047 cites W1964735685 @default.
- W2890741047 cites W1965079305 @default.
- W2890741047 cites W1965210942 @default.
- W2890741047 cites W1965403646 @default.
- W2890741047 cites W1965948140 @default.
- W2890741047 cites W1966518954 @default.
- W2890741047 cites W1971859980 @default.
- W2890741047 cites W1972240339 @default.
- W2890741047 cites W1976748679 @default.
- W2890741047 cites W1978977923 @default.
- W2890741047 cites W1980455487 @default.
- W2890741047 cites W1982024925 @default.
- W2890741047 cites W1982928579 @default.
- W2890741047 cites W1983872288 @default.
- W2890741047 cites W1984138776 @default.
- W2890741047 cites W1984856445 @default.
- W2890741047 cites W1986003236 @default.
- W2890741047 cites W1988756997 @default.
- W2890741047 cites W1990006998 @default.
- W2890741047 cites W1990272356 @default.
- W2890741047 cites W1992678387 @default.
- W2890741047 cites W1996255031 @default.
- W2890741047 cites W1996659589 @default.
- W2890741047 cites W1998854328 @default.
- W2890741047 cites W1999021477 @default.
- W2890741047 cites W1999159221 @default.
- W2890741047 cites W1999699035 @default.
- W2890741047 cites W1999919824 @default.
- W2890741047 cites W2000867339 @default.
- W2890741047 cites W2002125583 @default.
- W2890741047 cites W2005088640 @default.
- W2890741047 cites W2005090222 @default.
- W2890741047 cites W2006704562 @default.
- W2890741047 cites W2007819480 @default.
- W2890741047 cites W2008152365 @default.
- W2890741047 cites W2008172969 @default.
- W2890741047 cites W2009785737 @default.
- W2890741047 cites W2013200336 @default.
- W2890741047 cites W2015536606 @default.
- W2890741047 cites W2016936385 @default.
- W2890741047 cites W2017742632 @default.
- W2890741047 cites W2020657404 @default.
- W2890741047 cites W2023530279 @default.
- W2890741047 cites W2023674811 @default.
- W2890741047 cites W2024827171 @default.
- W2890741047 cites W2026722205 @default.
- W2890741047 cites W2028124725 @default.
- W2890741047 cites W2028875312 @default.
- W2890741047 cites W2029144840 @default.
- W2890741047 cites W2032301380 @default.
- W2890741047 cites W2032693257 @default.
- W2890741047 cites W2036573181 @default.
- W2890741047 cites W2038586595 @default.
- W2890741047 cites W2040035065 @default.
- W2890741047 cites W2040191772 @default.
- W2890741047 cites W2040328785 @default.
- W2890741047 cites W2047306805 @default.
- W2890741047 cites W2047833003 @default.
- W2890741047 cites W2050741966 @default.
- W2890741047 cites W2051516736 @default.
- W2890741047 cites W2053033635 @default.
- W2890741047 cites W2053260773 @default.
- W2890741047 cites W2053303702 @default.
- W2890741047 cites W2053483620 @default.
- W2890741047 cites W2057498089 @default.