Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890741641> ?p ?o ?g. }
- W2890741641 abstract "Abstract Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the molecular mechanisms responsible for the proliferation of osteoblast progenitors remain unclear. The early onset of Runx2 expression caused limb defects through the Fgfr1 –3 regulation by Runx2. To investigate the physiological role of Runx2 in the regulation of Fgfr1 – 3 , we compared osteoblast progenitors in Sp7 −/− and Runx2 −/− mice. Osteoblast progenitors accumulated and actively proliferated in calvariae and mandibles of Sp7 −/− but not of Runx2 −/− mice, and the number of osteoblast progenitors and their proliferation were dependent on the gene dosage of Runx2 in Sp7 −/− background. The expression of Fgfr2 and Fgfr3 , which were responsible for the proliferation of osteoblast progenitors, was severely reduced in Runx2 −/− but not in Sp7 −/− calvariae. Runx2 directly regulated Fgfr2 and Fgfr3 , increased the proliferation of osteoblast progenitors, and augmented the FGF2-induced proliferation. The proliferation of Sp7 −/− osteoblast progenitors was enhanced and strongly augmented by FGF2, and Runx2 knockdown reduced the FGF2-induced proliferation. Fgfr inhibitor AZD4547 abrogated all of the enhanced proliferation. These results indicate that Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation, at least partly, by regulating Fgfr2 and Fgfr3 expression." @default.
- W2890741641 created "2018-09-27" @default.
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- W2890741641 date "2018-09-10" @default.
- W2890741641 modified "2023-10-17" @default.
- W2890741641 title "Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3" @default.
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- W2890741641 cites W1978596841 @default.
- W2890741641 cites W1982990560 @default.
- W2890741641 cites W1988127349 @default.
- W2890741641 cites W1990047655 @default.
- W2890741641 cites W1990665236 @default.
- W2890741641 cites W1994664175 @default.
- W2890741641 cites W1997812904 @default.
- W2890741641 cites W2000224896 @default.
- W2890741641 cites W2000706451 @default.
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- W2890741641 cites W2006423274 @default.
- W2890741641 cites W2007215331 @default.
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- W2890741641 cites W2013714561 @default.
- W2890741641 cites W2013977089 @default.
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- W2890741641 cites W2021948683 @default.
- W2890741641 cites W2027770279 @default.
- W2890741641 cites W2028828556 @default.
- W2890741641 cites W2052772983 @default.
- W2890741641 cites W2053734323 @default.
- W2890741641 cites W2056983875 @default.
- W2890741641 cites W2059532513 @default.
- W2890741641 cites W2063170763 @default.
- W2890741641 cites W2072303535 @default.
- W2890741641 cites W2079475603 @default.
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- W2890741641 cites W2086938034 @default.
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- W2890741641 cites W2097090948 @default.
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- W2890741641 cites W2101066807 @default.
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- W2890741641 doi "https://doi.org/10.1038/s41598-018-31853-0" @default.
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