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- W2890743399 abstract "This doctoral work culminated in a circuit design capable of detecting bi-molecular proximity events, which we named “split proximity circuit (SPC)”. The circuit assembles dynamically on the target recognition sites in a self-contained manner to execute localized strand displacement. A recurring theme in this thesis was to minimize circuit leakages and a major contribution of this thesis was the development of several key counter-leakage strategies which were demonstrated in two concepts of association toehold and hybridization chain reaction. These strategies should be useful for designing DNA circuits in general and particularly as a starting point for researchers outside the DNA circuitry field. In terms of assay development, the greatest advantages of the SPC are its operation simplicity and plug-and-play versatility when compared to existing detection technologies. Looking forward, the functionality of SPC can be expanded by modifying individual module, e.g. detection of live cells, using secondary antibody as the recognition moiety and incorporating a functional downstream output. Other scientific directions to be explored include the self-contained logic gate design on cell surfaces and enzymatic production of “defect-free” oligonucleotide strands." @default.
- W2890743399 created "2018-09-27" @default.
- W2890743399 creator A5087942822 @default.
- W2890743399 date "2018-01-01" @default.
- W2890743399 modified "2023-09-27" @default.
- W2890743399 title "Conclusion and Future Outlooks" @default.
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- W2890743399 doi "https://doi.org/10.1007/978-981-13-2188-7_9" @default.
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