FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890744214> ?p ?o ?g. }

• W2890744214 endingPage "36.e3" @default.
• W2890744214 startingPage "30" @default.
• W2890744214 abstract "Major guidelines do not recommend routine molecular profiling of lung squamous-cell carcinoma (LUSC) because the prevalence of actionable alterations is thought to be low. Increased utilization of next-generation sequencing (NGS), particularly with cell-free circulating tumor DNA, facilitates reevaluation of this premise. PATIENTS AND METHODS: We retrospectively evaluated the prevalence of actionable alterations in 2 distinct LUSC cohorts totaling 492 patients. A total of 410 consecutive patients with stage 3B or 4 LUSC were tested with a targeted cell-free circulating DNA NGS assay, and 82 patients with LUSC of any stage were tested with a tissue NGS cancer panel.In the overall cohort, 467 patients (94.9%) had a diagnosis of LUSC, and 25 patients (5.1%) had mixed histology with a squamous component. A total of 10.5% of the LUSC subgroup had somatic alterations with therapeutic relevance, including in EGFR (2.8%), ALK/ROS1 (1.3%), BRAF (1.5%), and MET amplification or exon 14 skipping (5.1%). Sixteen percent of patients with mixed histology had an actionable alteration. In the LUSC subgroup, 3 evaluable patients were treated with targeted therapy for an actionable alteration; all of them experienced partial response.In this large, real-world LUSC cohort, we observed a clinically significant prevalence of actionable alterations. Accurate local histopathologic assessment in advanced-stage LUSC can be challenging. Further evaluation of the genomic landscape in this setting is warranted to potentially identify underappreciated treatment options." @default.
• W2890744214 created "2018-09-27" @default.
• W2890744214 creator A5008790176 @default.
• W2890744214 creator A5013271919 @default.
• W2890744214 creator A5014411546 @default.
• W2890744214 creator A5023516148 @default.
• W2890744214 creator A5025095617 @default.
• W2890744214 creator A5027152610 @default.
• W2890744214 creator A5029399672 @default.
• W2890744214 creator A5041570474 @default.
• W2890744214 creator A5048380048 @default.
• W2890744214 creator A5049023530 @default.
• W2890744214 creator A5054365404 @default.
• W2890744214 creator A5056267838 @default.
• W2890744214 creator A5060262778 @default.
• W2890744214 creator A5063752111 @default.
• W2890744214 creator A5070079018 @default.
• W2890744214 creator A5076621000 @default.
• W2890744214 date "2019-01-01" @default.
• W2890744214 modified "2023-10-16" @default.
• W2890744214 title "Targeted Tissue and Cell-Free Tumor DNA Sequencing of Advanced Lung Squamous-Cell Carcinoma Reveals Clinically Significant Prevalence of Actionable Alterations" @default.
• W2890744214 cites W1864344361 @default.
• W2890744214 cites W1978044919 @default.
• W2890744214 cites W2005312471 @default.
• W2890744214 cites W2019607817 @default.
• W2890744214 cites W2022789032 @default.
• W2890744214 cites W2040665303 @default.
• W2890744214 cites W2091383172 @default.
• W2890744214 cites W2105805568 @default.
• W2890744214 cites W2114843025 @default.
• W2890744214 cites W2129590156 @default.
• W2890744214 cites W2130588193 @default.
• W2890744214 cites W2137043950 @default.
• W2890744214 cites W2140980839 @default.
• W2890744214 cites W2149441684 @default.
• W2890744214 cites W2167599107 @default.
• W2890744214 cites W2168404690 @default.
• W2890744214 cites W2169624569 @default.
• W2890744214 cites W2170744484 @default.
• W2890744214 cites W2230948985 @default.
• W2890744214 cites W2251227974 @default.
• W2890744214 cites W2251438188 @default.
• W2890744214 cites W2275877493 @default.
• W2890744214 cites W2346025119 @default.
• W2890744214 cites W2402712181 @default.
• W2890744214 cites W2439107762 @default.
• W2890744214 cites W2466657922 @default.
• W2890744214 cites W2472596403 @default.
• W2890744214 cites W2508716485 @default.
• W2890744214 cites W2513860830 @default.
• W2890744214 cites W2584455808 @default.
• W2890744214 cites W2586898085 @default.
• W2890744214 cites W2600348349 @default.
• W2890744214 cites W2614443510 @default.
• W2890744214 cites W2780582854 @default.
• W2890744214 cites W2785515282 @default.
• W2890744214 cites W2800224623 @default.
• W2890744214 cites W2808333976 @default.
• W2890744214 cites W4254835305 @default.
• W2890744214 doi "https://doi.org/10.1016/j.cllc.2018.08.020" @default.
• W2890744214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30279110" @default.
• W2890744214 hasPublicationYear "2019" @default.
• W2890744214 type Work @default.
• W2890744214 sameAs 2890744214 @default.
• W2890744214 citedByCount "30" @default.
• W2890744214 countsByYear W28907442142019 @default.
• W2890744214 countsByYear W28907442142020 @default.
• W2890744214 countsByYear W28907442142021 @default.
• W2890744214 countsByYear W28907442142022 @default.
• W2890744214 countsByYear W28907442142023 @default.
• W2890744214 crossrefType "journal-article" @default.
• W2890744214 hasAuthorship W2890744214A5008790176 @default.
• W2890744214 hasAuthorship W2890744214A5013271919 @default.
• W2890744214 hasAuthorship W2890744214A5014411546 @default.
• W2890744214 hasAuthorship W2890744214A5023516148 @default.
• W2890744214 hasAuthorship W2890744214A5025095617 @default.
• W2890744214 hasAuthorship W2890744214A5027152610 @default.
• W2890744214 hasAuthorship W2890744214A5029399672 @default.
• W2890744214 hasAuthorship W2890744214A5041570474 @default.
• W2890744214 hasAuthorship W2890744214A5048380048 @default.
• W2890744214 hasAuthorship W2890744214A5049023530 @default.
• W2890744214 hasAuthorship W2890744214A5054365404 @default.
• W2890744214 hasAuthorship W2890744214A5056267838 @default.
• W2890744214 hasAuthorship W2890744214A5060262778 @default.
• W2890744214 hasAuthorship W2890744214A5063752111 @default.
• W2890744214 hasAuthorship W2890744214A5070079018 @default.
• W2890744214 hasAuthorship W2890744214A5076621000 @default.
• W2890744214 hasBestOaLocation W28907442141 @default.
• W2890744214 hasConcept C121608353 @default.
• W2890744214 hasConcept C126322002 @default.
• W2890744214 hasConcept C142724271 @default.
• W2890744214 hasConcept C143998085 @default.
• W2890744214 hasConcept C146357865 @default.
• W2890744214 hasConcept C151730666 @default.
• W2890744214 hasConcept C2775999482 @default.
• W2890744214 hasConcept C2776256026 @default.
• W2890744214 hasConcept C2781182431 @default.
• W2890744214 hasConcept C2781230642 @default.

• next