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- W2890753179 abstract "Background Cognitive impairment may increase the risk of all‐cause and cardiovascular disease ( CVD ) mortality. This study examined the association between cognitive function and risk of all‐cause and CVD mortality among the elderly in Beijing, China. Methods and Results A total of 1996 participants aged ≥55 years at baseline were enrolled from the BLSA (Beijing Longitudinal Study of Aging). Cognitive function was assessed using the Mini‐Mental State Examination ( MMSE ), and participants were categorized as: <18, 18 to 23, 24 to 27, and 28 to 30. Cox proportional hazard models were used to estimate the association. Hazard ratio ( HR ) and 95% confidence interval ( CI ) were reported. During a 20‐year follow‐up, 1122 (56.21%) participants died, 478 (42.60%) of whom died of CVD . Compared with MMSE scores of 28 to 30, participants with MMSE scores of <18 were independently associated with all‐cause mortality ( hazard ratio, 2.14; 95% confidence interval, 1.59–2.87; P <0.001) and CVD mortality (hazard ratio , 4.52; 95% confidence interval , 2.80–7.30, P <0.001). Each 5‐point decrease in MMSE score was associated with a 34% increased risk of all‐cause mortality and a 56% increased risk of CVD mortality. This relationship remained statistically significant after using the competing risk model to consider non‐ CVD death as a competing risk event. Conclusion Cognitive impairment measured by MMSE score was associated with elevated risk of all‐cause and CVD mortality among the elderly in Beijing, China." @default.
- W2890753179 created "2018-09-27" @default.
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- W2890753179 date "2018-08-07" @default.
- W2890753179 modified "2023-10-14" @default.
- W2890753179 title "Cognitive Impairment and Risk of All‐Cause and Cardiovascular Disease Mortality Over 20‐Year Follow‐up: Results From the BLSA" @default.
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- W2890753179 doi "https://doi.org/10.1161/jaha.117.008252" @default.
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