FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890764438> ?p ?o ?g. }

• W2890764438 endingPage "30" @default.
• W2890764438 startingPage "23" @default.
• W2890764438 abstract "The major organic component of bone is collagen type I. Osteoclasts are terminally differentiated multinucleated cells of hematopoietic origin that are essential for physiological development of bone and teeth. We examined if osteoclast differentiation from murine bone marrow precursors is affected by collagen type I, or by its degradation products produced by human recombinant cathepsin K. Osteoclasts formation was dose-dependently inhibited in the presence of full length collagen type I or its 30–75 kDa degradation products added to the osteoclast differentiation media for the duration of an experiment. Collagen degradation fragments signaled through SH-2 phosphatases, inhibiting calcium signaling and NFATc1 translocation in osteoclast precursors. Osteoclasts and their precursors expressed a collagen receptor of leukocyte receptor complex family, LAIR-1. Importantly, collagen fragments failed to inhibit osteoclast formation from LAIR-1 deficient murine osteoclast precursors. This study demonstrates that collagen degradation fragments inhibit osteoclast formation acting through LAIR-1, providing a novel mechanism for the physiologically-relevant negative control of osteoclastogenesis." @default.
• W2890764438 created "2018-09-27" @default.
• W2890764438 creator A5006605423 @default.
• W2890764438 creator A5008405644 @default.
• W2890764438 creator A5059872132 @default.
• W2890764438 creator A5083653940 @default.
• W2890764438 creator A5085462956 @default.
• W2890764438 creator A5087725919 @default.
• W2890764438 date "2018-12-01" @default.
• W2890764438 modified "2023-10-17" @default.
• W2890764438 title "Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation" @default.
• W2890764438 cites W1485297825 @default.
• W2890764438 cites W1502613487 @default.
• W2890764438 cites W1975505424 @default.
• W2890764438 cites W1994517874 @default.
• W2890764438 cites W2003657739 @default.
• W2890764438 cites W2003829769 @default.
• W2890764438 cites W2020087564 @default.
• W2890764438 cites W2020370649 @default.
• W2890764438 cites W2023211510 @default.
• W2890764438 cites W2028672566 @default.
• W2890764438 cites W2030240788 @default.
• W2890764438 cites W2051449475 @default.
• W2890764438 cites W2064603645 @default.
• W2890764438 cites W2067439258 @default.
• W2890764438 cites W2071456270 @default.
• W2890764438 cites W2077386452 @default.
• W2890764438 cites W2090392995 @default.
• W2890764438 cites W2093252878 @default.
• W2890764438 cites W2096174329 @default.
• W2890764438 cites W2109350686 @default.
• W2890764438 cites W2131381643 @default.
• W2890764438 cites W2133452036 @default.
• W2890764438 cites W2136439811 @default.
• W2890764438 cites W2139090888 @default.
• W2890764438 cites W2140054285 @default.
• W2890764438 cites W2155893315 @default.
• W2890764438 cites W2157447805 @default.
• W2890764438 cites W2597918070 @default.
• W2890764438 doi "https://doi.org/10.1016/j.bone.2018.09.006" @default.
• W2890764438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30217615" @default.
• W2890764438 hasPublicationYear "2018" @default.
• W2890764438 type Work @default.
• W2890764438 sameAs 2890764438 @default.
• W2890764438 citedByCount "15" @default.
• W2890764438 countsByYear W28907644382020 @default.
• W2890764438 countsByYear W28907644382021 @default.
• W2890764438 countsByYear W28907644382022 @default.
• W2890764438 countsByYear W28907644382023 @default.
• W2890764438 crossrefType "journal-article" @default.
• W2890764438 hasAuthorship W2890764438A5006605423 @default.
• W2890764438 hasAuthorship W2890764438A5008405644 @default.
• W2890764438 hasAuthorship W2890764438A5059872132 @default.
• W2890764438 hasAuthorship W2890764438A5083653940 @default.
• W2890764438 hasAuthorship W2890764438A5085462956 @default.
• W2890764438 hasAuthorship W2890764438A5087725919 @default.
• W2890764438 hasBestOaLocation W28907644382 @default.
• W2890764438 hasConcept C101990758 @default.
• W2890764438 hasConcept C109159458 @default.
• W2890764438 hasConcept C134018914 @default.
• W2890764438 hasConcept C153911025 @default.
• W2890764438 hasConcept C170493617 @default.
• W2890764438 hasConcept C185592680 @default.
• W2890764438 hasConcept C2776033226 @default.
• W2890764438 hasConcept C2780644872 @default.
• W2890764438 hasConcept C28328180 @default.
• W2890764438 hasConcept C55493867 @default.
• W2890764438 hasConcept C673006 @default.
• W2890764438 hasConcept C86803240 @default.
• W2890764438 hasConcept C95444343 @default.
• W2890764438 hasConceptScore W2890764438C101990758 @default.
• W2890764438 hasConceptScore W2890764438C109159458 @default.
• W2890764438 hasConceptScore W2890764438C134018914 @default.
• W2890764438 hasConceptScore W2890764438C153911025 @default.
• W2890764438 hasConceptScore W2890764438C170493617 @default.
• W2890764438 hasConceptScore W2890764438C185592680 @default.
• W2890764438 hasConceptScore W2890764438C2776033226 @default.
• W2890764438 hasConceptScore W2890764438C2780644872 @default.
• W2890764438 hasConceptScore W2890764438C28328180 @default.
• W2890764438 hasConceptScore W2890764438C55493867 @default.
• W2890764438 hasConceptScore W2890764438C673006 @default.
• W2890764438 hasConceptScore W2890764438C86803240 @default.
• W2890764438 hasConceptScore W2890764438C95444343 @default.
• W2890764438 hasFunder F4320310864 @default.
• W2890764438 hasFunder F4320313193 @default.
• W2890764438 hasFunder F4320334506 @default.
• W2890764438 hasLocation W28907644381 @default.
• W2890764438 hasLocation W28907644382 @default.
• W2890764438 hasOpenAccess W2890764438 @default.
• W2890764438 hasPrimaryLocation W28907644381 @default.
• W2890764438 hasRelatedWork W1992026462 @default.
• W2890764438 hasRelatedWork W2020087564 @default.
• W2890764438 hasRelatedWork W2039002419 @default.
• W2890764438 hasRelatedWork W2116727386 @default.
• W2890764438 hasRelatedWork W2132517007 @default.
• W2890764438 hasRelatedWork W2908234188 @default.
• W2890764438 hasRelatedWork W2935970786 @default.
• W2890764438 hasRelatedWork W2980604510 @default.

• next