Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890764958> ?p ?o ?g. }
- W2890764958 endingPage "1302" @default.
- W2890764958 startingPage "1297" @default.
- W2890764958 abstract "The CNS of the protovertebrate Ciona intestinalis contains a single cluster of dopaminergic (DA) neurons, the coronet cells, which have been likened to the hypothalamus of vertebrates. Whole-embryo single-cell RNA sequencing (RNA-seq) assays identified Ptf1a as the most strongly expressed cell-specific transcription factor (TF) in DA/coronet cells. Knockdown of Ptf1a activity results in their loss, while misexpression results in the appearance of supernumerary DA/coronet cells. Photoreceptor cells and ependymal cells are the most susceptible to transformation, and both cell types express high levels of Meis Coexpression of both Ptf1a and Meis caused the wholesale transformation of the entire CNS into DA/coronet cells. We therefore suggest that the reiterative use of functional manipulations and single-cell RNA-seq assays is an effective means for the identification of regulatory cocktails underlying the specification of specific cell identities." @default.
- W2890764958 created "2018-09-27" @default.
- W2890764958 creator A5000217483 @default.
- W2890764958 creator A5004162629 @default.
- W2890764958 creator A5011017379 @default.
- W2890764958 creator A5013053628 @default.
- W2890764958 creator A5031719470 @default.
- W2890764958 creator A5049432621 @default.
- W2890764958 creator A5074339191 @default.
- W2890764958 creator A5081284588 @default.
- W2890764958 creator A5091748608 @default.
- W2890764958 date "2018-09-18" @default.
- W2890764958 modified "2023-10-15" @default.
- W2890764958 title "Regulatory cocktail for dopaminergic neurons in a protovertebrate identified by whole-embryo single-cell transcriptomics" @default.
- W2890764958 cites W1981389530 @default.
- W2890764958 cites W1986390363 @default.
- W2890764958 cites W1987325881 @default.
- W2890764958 cites W1988623932 @default.
- W2890764958 cites W1993314362 @default.
- W2890764958 cites W2023628415 @default.
- W2890764958 cites W2050103288 @default.
- W2890764958 cites W2050952728 @default.
- W2890764958 cites W2069089843 @default.
- W2890764958 cites W2069091386 @default.
- W2890764958 cites W2071351491 @default.
- W2890764958 cites W2072083009 @default.
- W2890764958 cites W2072977772 @default.
- W2890764958 cites W2080832893 @default.
- W2890764958 cites W2081592335 @default.
- W2890764958 cites W2088171805 @default.
- W2890764958 cites W2094153344 @default.
- W2890764958 cites W2100826819 @default.
- W2890764958 cites W2103230093 @default.
- W2890764958 cites W2115154860 @default.
- W2890764958 cites W2124673755 @default.
- W2890764958 cites W2137678380 @default.
- W2890764958 cites W2151557671 @default.
- W2890764958 cites W2163799569 @default.
- W2890764958 cites W2169186378 @default.
- W2890764958 cites W2543278732 @default.
- W2890764958 cites W2544973020 @default.
- W2890764958 cites W2559748052 @default.
- W2890764958 cites W2605624585 @default.
- W2890764958 cites W2623843598 @default.
- W2890764958 cites W2784259888 @default.
- W2890764958 cites W2794480084 @default.
- W2890764958 cites W2799796757 @default.
- W2890764958 cites W2800028441 @default.
- W2890764958 cites W2800789348 @default.
- W2890764958 cites W2800912249 @default.
- W2890764958 cites W2801443765 @default.
- W2890764958 cites W2802302382 @default.
- W2890764958 cites W2811084193 @default.
- W2890764958 cites W2887705226 @default.
- W2890764958 cites W2952591330 @default.
- W2890764958 doi "https://doi.org/10.1101/gad.317669.118" @default.
- W2890764958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6169837" @default.
- W2890764958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30228204" @default.
- W2890764958 hasPublicationYear "2018" @default.
- W2890764958 type Work @default.
- W2890764958 sameAs 2890764958 @default.
- W2890764958 citedByCount "33" @default.
- W2890764958 countsByYear W28907649582019 @default.
- W2890764958 countsByYear W28907649582020 @default.
- W2890764958 countsByYear W28907649582021 @default.
- W2890764958 countsByYear W28907649582022 @default.
- W2890764958 countsByYear W28907649582023 @default.
- W2890764958 crossrefType "journal-article" @default.
- W2890764958 hasAuthorship W2890764958A5000217483 @default.
- W2890764958 hasAuthorship W2890764958A5004162629 @default.
- W2890764958 hasAuthorship W2890764958A5011017379 @default.
- W2890764958 hasAuthorship W2890764958A5013053628 @default.
- W2890764958 hasAuthorship W2890764958A5031719470 @default.
- W2890764958 hasAuthorship W2890764958A5049432621 @default.
- W2890764958 hasAuthorship W2890764958A5074339191 @default.
- W2890764958 hasAuthorship W2890764958A5081284588 @default.
- W2890764958 hasAuthorship W2890764958A5091748608 @default.
- W2890764958 hasBestOaLocation W28907649581 @default.
- W2890764958 hasConcept C104317684 @default.
- W2890764958 hasConcept C137183658 @default.
- W2890764958 hasConcept C1491633281 @default.
- W2890764958 hasConcept C150194340 @default.
- W2890764958 hasConcept C162317418 @default.
- W2890764958 hasConcept C166703698 @default.
- W2890764958 hasConcept C169760540 @default.
- W2890764958 hasConcept C173396325 @default.
- W2890764958 hasConcept C189014844 @default.
- W2890764958 hasConcept C196843134 @default.
- W2890764958 hasConcept C513476851 @default.
- W2890764958 hasConcept C54355233 @default.
- W2890764958 hasConcept C67705224 @default.
- W2890764958 hasConcept C81885089 @default.
- W2890764958 hasConcept C86339819 @default.
- W2890764958 hasConcept C86803240 @default.
- W2890764958 hasConcept C95444343 @default.
- W2890764958 hasConceptScore W2890764958C104317684 @default.
- W2890764958 hasConceptScore W2890764958C137183658 @default.
- W2890764958 hasConceptScore W2890764958C1491633281 @default.