FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890768188> ?p ?o ?g. }

• W2890768188 endingPage "1457" @default.
• W2890768188 startingPage "1449" @default.
• W2890768188 abstract "Phoenixin-14 (PNX) is a newly discovered peptide produced by proteolytic cleavage of the small integral membrane protein 20 (Smim20). Previous studies showed that PNX is involved in controlling reproduction, pain, anxiety and memory. Furthermore, in humans, PNX positively correlates with BMI suggesting a potential role of PNX in controlling fat accumulation in obesity. Since the influence of PNX on adipose tissue formation has not been so far demonstrated, we investigated the effects of PNX on proliferation and differentiation of preadipocytes using 3T3-L1 and rat primary preadipocytes. We detected Smim20 and Gpr173 mRNA in 3T3-L1 preadipocytes as well as in rat primary preadipocytes. Furthermore, we found that PNX peptide is produced and secreted from 3T3-L1 and rat primary adipocytes. PNX increased 3T3-L1 preadipocytes proliferation and viability. PNX stimulated the expression of adipogenic genes (Pparγ, C/ebpβ and Fabp4) in 3T3-L1 adipocytes. 3T3-L1 preadipocytes differentiated in the presence of PNX had increased lipid content. Stimulation of cell proliferation and differentiation by PNX was also confirmed in rat preadipocytes. PNX failed to induce AKT phosphorylation, however, PNX increased cAMP levels in 3T3-L1 cells. Suppression of Epac signalling attenuated PNX-induced Pparγ expression without affecting cell proliferation. Our data show that PNX stimulates differentiation of 3T3-L1 and rat primary preadipocytes into mature adipocytes via cAMP/Epac-dependent pathway. In conclusion our data shows that phoenixin promotes white adipogenesis, thereby may be involved in controlling body mass regulation." @default.
• W2890768188 created "2018-09-27" @default.
• W2890768188 creator A5017554804 @default.
• W2890768188 creator A5028159140 @default.
• W2890768188 creator A5062063876 @default.
• W2890768188 creator A5063613127 @default.
• W2890768188 creator A5068093546 @default.
• W2890768188 creator A5072925592 @default.
• W2890768188 creator A5074676016 @default.
• W2890768188 creator A5080827425 @default.
• W2890768188 creator A5087160874 @default.
• W2890768188 date "2018-12-01" @default.
• W2890768188 modified "2023-10-14" @default.
• W2890768188 title "Phoenixin-14 stimulates differentiation of 3T3-L1 preadipocytes via cAMP/Epac-dependent mechanism" @default.
• W2890768188 cites W1529396499 @default.
• W2890768188 cites W1750935159 @default.
• W2890768188 cites W1890450187 @default.
• W2890768188 cites W1941545295 @default.
• W2890768188 cites W1980776054 @default.
• W2890768188 cites W1988294190 @default.
• W2890768188 cites W2019785517 @default.
• W2890768188 cites W2019963667 @default.
• W2890768188 cites W2028817918 @default.
• W2890768188 cites W2036874807 @default.
• W2890768188 cites W2054965892 @default.
• W2890768188 cites W2060534660 @default.
• W2890768188 cites W2067913177 @default.
• W2890768188 cites W2069237083 @default.
• W2890768188 cites W2082775813 @default.
• W2890768188 cites W2097899015 @default.
• W2890768188 cites W2102313291 @default.
• W2890768188 cites W2123723993 @default.
• W2890768188 cites W2130166672 @default.
• W2890768188 cites W2133470303 @default.
• W2890768188 cites W2158864582 @default.
• W2890768188 cites W2171241069 @default.
• W2890768188 cites W2284433125 @default.
• W2890768188 cites W2336833178 @default.
• W2890768188 cites W2410812161 @default.
• W2890768188 cites W2520995681 @default.
• W2890768188 cites W2602169952 @default.
• W2890768188 cites W2625085077 @default.
• W2890768188 cites W2746691417 @default.
• W2890768188 cites W2754366054 @default.
• W2890768188 cites W2757760289 @default.
• W2890768188 cites W48179498 @default.
• W2890768188 doi "https://doi.org/10.1016/j.bbalip.2018.09.006" @default.
• W2890768188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30251651" @default.
• W2890768188 hasPublicationYear "2018" @default.
• W2890768188 type Work @default.
• W2890768188 sameAs 2890768188 @default.
• W2890768188 citedByCount "27" @default.
• W2890768188 countsByYear W28907681882019 @default.
• W2890768188 countsByYear W28907681882020 @default.
• W2890768188 countsByYear W28907681882021 @default.
• W2890768188 countsByYear W28907681882022 @default.
• W2890768188 countsByYear W28907681882023 @default.
• W2890768188 crossrefType "journal-article" @default.
• W2890768188 hasAuthorship W2890768188A5017554804 @default.
• W2890768188 hasAuthorship W2890768188A5028159140 @default.
• W2890768188 hasAuthorship W2890768188A5062063876 @default.
• W2890768188 hasAuthorship W2890768188A5063613127 @default.
• W2890768188 hasAuthorship W2890768188A5068093546 @default.
• W2890768188 hasAuthorship W2890768188A5072925592 @default.
• W2890768188 hasAuthorship W2890768188A5074676016 @default.
• W2890768188 hasAuthorship W2890768188A5080827425 @default.
• W2890768188 hasAuthorship W2890768188A5087160874 @default.
• W2890768188 hasConcept C122927707 @default.
• W2890768188 hasConcept C126322002 @default.
• W2890768188 hasConcept C134018914 @default.
• W2890768188 hasConcept C142536801 @default.
• W2890768188 hasConcept C171089720 @default.
• W2890768188 hasConcept C2776746612 @default.
• W2890768188 hasConcept C54009773 @default.
• W2890768188 hasConcept C54355233 @default.
• W2890768188 hasConcept C71924100 @default.
• W2890768188 hasConcept C81885089 @default.
• W2890768188 hasConcept C86803240 @default.
• W2890768188 hasConcept C95444343 @default.
• W2890768188 hasConceptScore W2890768188C122927707 @default.
• W2890768188 hasConceptScore W2890768188C126322002 @default.
• W2890768188 hasConceptScore W2890768188C134018914 @default.
• W2890768188 hasConceptScore W2890768188C142536801 @default.
• W2890768188 hasConceptScore W2890768188C171089720 @default.
• W2890768188 hasConceptScore W2890768188C2776746612 @default.
• W2890768188 hasConceptScore W2890768188C54009773 @default.
• W2890768188 hasConceptScore W2890768188C54355233 @default.
• W2890768188 hasConceptScore W2890768188C71924100 @default.
• W2890768188 hasConceptScore W2890768188C81885089 @default.
• W2890768188 hasConceptScore W2890768188C86803240 @default.
• W2890768188 hasConceptScore W2890768188C95444343 @default.
• W2890768188 hasFunder F4320322511 @default.
• W2890768188 hasIssue "12" @default.
• W2890768188 hasLocation W28907681881 @default.
• W2890768188 hasLocation W28907681882 @default.
• W2890768188 hasOpenAccess W2890768188 @default.
• W2890768188 hasPrimaryLocation W28907681881 @default.
• W2890768188 hasRelatedWork W1964688190 @default.

• next