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• W2890774294 startingPage "1481" @default.
• W2890774294 abstract "Over the past decade, optical methods have emerged for modulating brain functions as an alternative to electrical stimulation. Among various optical techniques, infrared neural stimulation has been effective via a thermal mechanism enabling focused and noninvasive stimulation without any genetic manipulation, but it results in bulk heating of neural tissue. Recently, it has been shown that neural cells can be activated more efficiently by pulsed near-infrared (NIR) light delivered to gold nanorods (GNRs) near the neural cells. Despite its potential, however, the biophysical mechanism underlying this GNR-enhanced NIR stimulation has not been clearly explained yet. Here, we propose an integrative and quantitative model to elucidate the mechanism by modeling heat generated from interaction between NIR light and GNRs, the temperature-dependent ion channels (transient receptor potential vanilloid 1; TRPV1) in the neuronal membrane, and a heat-induced capacitive current through the membrane. Our results show that NIR pulses induce abrupt temperature elevation near the neuronal membrane and lead to both the TRPV1-channel and capacitive currents. Both current sources synergistically increase the membrane potential and elicit an action potential, and which mechanism is dominant depends on conditions such as the laser pulse duration and TRPV1 channel density. Although the TRPV1 mechanism dominates in most cases we tested, the capacitive current makes a larger contribution when a very short laser pulse is illuminated on neural cells with relatively low TRPV1 channel densities." @default.
• W2890774294 created "2018-09-27" @default.
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• W2890774294 date "2018-10-01" @default.
• W2890774294 modified "2023-10-17" @default.
• W2890774294 title "Theoretical Study on Gold-Nanorod-Enhanced Near-Infrared Neural Stimulation" @default.
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• W2890774294 doi "https://doi.org/10.1016/j.bpj.2018.09.004" @default.
• W2890774294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6372194" @default.
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• W2890774294 hasPublicationYear "2018" @default.
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