Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890774414> ?p ?o ?g. }
- W2890774414 endingPage "e2006337" @default.
- W2890774414 startingPage "e2006337" @default.
- W2890774414 abstract "Pregnancy and parturition are intricately regulated to ensure successful reproductive outcomes. However, the factors that control gestational length in humans and other anthropoid primates remain poorly defined. Here, we show the endogenous retroviral long terminal repeat transposon-like human element 1B (THE1B) selectively controls placental expression of corticotropin-releasing hormone (CRH) that, in turn, influences gestational length and birth timing. Placental expression of CRH and subsequently prolonged gestational length were found in two independent strains of transgenic mice carrying a 180-kb human bacterial artificial chromosome (BAC) DNA that contained the full length of CRH and extended flanking regions, including THE1B. Restricted deletion of THE1B silenced placental CRH expression and normalized birth timing in these transgenic lines. Furthermore, we revealed an interaction at the 5' insertion site of THE1B with distal-less homeobox 3 (DLX3), a transcription factor expressed in placenta. Together, these findings suggest that retroviral insertion of THE1B into the anthropoid primate genome may have initiated expression of CRH in placental syncytiotrophoblasts via DLX3 and that this placental CRH is sufficient to alter the timing of birth." @default.
- W2890774414 created "2018-09-27" @default.
- W2890774414 creator A5005049952 @default.
- W2890774414 creator A5005518548 @default.
- W2890774414 creator A5009851124 @default.
- W2890774414 creator A5012213119 @default.
- W2890774414 creator A5015911043 @default.
- W2890774414 creator A5023365665 @default.
- W2890774414 creator A5032652974 @default.
- W2890774414 creator A5040383117 @default.
- W2890774414 creator A5055170129 @default.
- W2890774414 creator A5055232188 @default.
- W2890774414 creator A5055781321 @default.
- W2890774414 creator A5064940970 @default.
- W2890774414 creator A5068363917 @default.
- W2890774414 creator A5080833691 @default.
- W2890774414 creator A5082155475 @default.
- W2890774414 creator A5087337778 @default.
- W2890774414 creator A5037295995 @default.
- W2890774414 date "2018-09-19" @default.
- W2890774414 modified "2023-10-11" @default.
- W2890774414 title "Anthropoid primate–specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length" @default.
- W2890774414 cites W1085378696 @default.
- W2890774414 cites W1963527872 @default.
- W2890774414 cites W1964710559 @default.
- W2890774414 cites W1964891742 @default.
- W2890774414 cites W1965408671 @default.
- W2890774414 cites W1966116114 @default.
- W2890774414 cites W1967133523 @default.
- W2890774414 cites W1968846073 @default.
- W2890774414 cites W1969781989 @default.
- W2890774414 cites W1971392736 @default.
- W2890774414 cites W1974332832 @default.
- W2890774414 cites W1977709885 @default.
- W2890774414 cites W1978300791 @default.
- W2890774414 cites W1981005523 @default.
- W2890774414 cites W1983695223 @default.
- W2890774414 cites W1988420079 @default.
- W2890774414 cites W1991955154 @default.
- W2890774414 cites W1999574084 @default.
- W2890774414 cites W1999580244 @default.
- W2890774414 cites W2000609514 @default.
- W2890774414 cites W2006378451 @default.
- W2890774414 cites W2016295650 @default.
- W2890774414 cites W2021469711 @default.
- W2890774414 cites W2024173579 @default.
- W2890774414 cites W2025481697 @default.
- W2890774414 cites W2026690931 @default.
- W2890774414 cites W2031333605 @default.
- W2890774414 cites W2033169664 @default.
- W2890774414 cites W2035173149 @default.
- W2890774414 cites W2038919117 @default.
- W2890774414 cites W2043763150 @default.
- W2890774414 cites W2046982330 @default.
- W2890774414 cites W2047285578 @default.
- W2890774414 cites W2048492425 @default.
- W2890774414 cites W2048653677 @default.
- W2890774414 cites W2049790867 @default.
- W2890774414 cites W2051525197 @default.
- W2890774414 cites W2051671593 @default.
- W2890774414 cites W2052949642 @default.
- W2890774414 cites W2057061886 @default.
- W2890774414 cites W2061554747 @default.
- W2890774414 cites W2061741911 @default.
- W2890774414 cites W2062055359 @default.
- W2890774414 cites W2074637575 @default.
- W2890774414 cites W2082591996 @default.
- W2890774414 cites W2082959433 @default.
- W2890774414 cites W2090417409 @default.
- W2890774414 cites W2095475116 @default.
- W2890774414 cites W2098108740 @default.
- W2890774414 cites W2102400658 @default.
- W2890774414 cites W2102619694 @default.
- W2890774414 cites W2103573521 @default.
- W2890774414 cites W2105188889 @default.
- W2890774414 cites W2114104545 @default.
- W2890774414 cites W2115037403 @default.
- W2890774414 cites W2120162279 @default.
- W2890774414 cites W2122548940 @default.
- W2890774414 cites W2124756504 @default.
- W2890774414 cites W2126284582 @default.
- W2890774414 cites W2129109829 @default.
- W2890774414 cites W2135706199 @default.
- W2890774414 cites W2139367243 @default.
- W2890774414 cites W2140729960 @default.
- W2890774414 cites W2150911820 @default.
- W2890774414 cites W2159308963 @default.
- W2890774414 cites W2164207497 @default.
- W2890774414 cites W2168631252 @default.
- W2890774414 cites W2172039585 @default.
- W2890774414 cites W2172215633 @default.
- W2890774414 cites W2301736269 @default.
- W2890774414 cites W2323326409 @default.
- W2890774414 cites W2410616080 @default.
- W2890774414 cites W2521898456 @default.
- W2890774414 cites W2556763090 @default.
- W2890774414 cites W2564971068 @default.
- W2890774414 cites W2586681801 @default.