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- W2890775129 abstract "A novel class of 5H-[1,2,4]oxadiazolo[4,5-a]pyrimidine derivatives was prepared, characterized, and tested for its antibacterial and anticancer potential against thirteen strains and five human cancer cell lines. The synthetic method was optimized, and a proposed reaction mechanism was also presented. The compounds containing the 5-bromo-pyrimidine moiety exhibited moderate antibacterial potencies against Gram-positive strains. Furthermore, the newly prepared compounds displayed selectively antiproliferative activity against human cancer cell lines. These current results will help us to further optimize and develop new drug candidates for clinical studies as novel antibacterial or anticancer agents." @default.
- W2890775129 created "2018-09-27" @default.
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- W2890775129 date "2018-10-01" @default.
- W2890775129 modified "2023-10-16" @default.
- W2890775129 title "Novel 5H-[1,2,4]oxadiazolo[4,5-a]pyrimidin-5-one derivatives as antibacterial and anticancer agents: Synthesis and biological evaluation" @default.
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- W2890775129 doi "https://doi.org/10.1016/j.tetlet.2018.09.011" @default.
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