FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890775821> ?p ?o ?g. }

• W2890775821 abstract "In the development of new vaccines, understanding the level of vaccine-induced antibody that is sufficient to protect against disease can simplify and expedite the development and licensing process. If there is an accepted threshold antibody level that is indicative of protection, then smaller trials measuring antibody concentration alone can be conducted to test new vaccines, instead of large efficacy studies powered on clinical outcomes. Commonly, threshold levels of protective antibody are determined from clinical efficacy trials in which clinical endpoints are measured on everyone and a small subset of participants have antibody concentrations measured. The proportion of participants with antibody below a threshold in each group in the immunogenicity subset can be compared to the proportions with disease in each group in the larger trial to find an appropriate threshold. Mathematically, this method seeks to compute an absolute threshold whereby antibody above the threshold provides complete, sterilizing immunity. However, in practice it is often understood that such thresholds may only be indicative of a relative degree of protection rather than an absolute one. Although this approach is common, the accuracy of such methods when the underlying mathematical assumptions do not hold true, has never been tested. We simulated data from clinical trial scenarios under varying assumptions of vaccine efficacy and calculated antibody thresholds of protection. We estimated the bias in the calculated thresholds derived from each scenario and showed that in many situations this method produces inflated estimates of thresholds, particularly if a vaccine induces high levels of antibody or when the underlying assumption of sterilizing immunity is violated." @default.
• W2890775821 created "2018-09-27" @default.
• W2890775821 creator A5055232373 @default.
• W2890775821 creator A5065914659 @default.
• W2890775821 creator A5068864334 @default.
• W2890775821 creator A5082847955 @default.
• W2890775821 date "2018-09-07" @default.
• W2890775821 modified "2023-10-16" @default.
• W2890775821 title "Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias" @default.
• W2890775821 cites W1971518631 @default.
• W2890775821 cites W1991525954 @default.
• W2890775821 cites W2000611496 @default.
• W2890775821 cites W2009862707 @default.
• W2890775821 cites W2023690749 @default.
• W2890775821 cites W2048032218 @default.
• W2890775821 cites W2049532298 @default.
• W2890775821 cites W2072498492 @default.
• W2890775821 cites W2075357156 @default.
• W2890775821 cites W2076756245 @default.
• W2890775821 cites W2115116421 @default.
• W2890775821 cites W2122598469 @default.
• W2890775821 cites W2127666080 @default.
• W2890775821 cites W2128013943 @default.
• W2890775821 cites W2128589740 @default.
• W2890775821 cites W2129655108 @default.
• W2890775821 cites W2130460485 @default.
• W2890775821 cites W2130481574 @default.
• W2890775821 cites W2134945394 @default.
• W2890775821 cites W2135985984 @default.
• W2890775821 cites W2140447452 @default.
• W2890775821 cites W2472236449 @default.
• W2890775821 cites W2759562520 @default.
• W2890775821 cites W2767041608 @default.
• W2890775821 cites W2782889149 @default.
• W2890775821 cites W4231603137 @default.
• W2890775821 cites W4250873783 @default.
• W2890775821 doi "https://doi.org/10.1371/journal.pone.0202517" @default.
• W2890775821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128451" @default.
• W2890775821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192787" @default.
• W2890775821 hasPublicationYear "2018" @default.
• W2890775821 type Work @default.
• W2890775821 sameAs 2890775821 @default.
• W2890775821 citedByCount "3" @default.
• W2890775821 countsByYear W28907758212020 @default.
• W2890775821 countsByYear W28907758212022 @default.
• W2890775821 crossrefType "journal-article" @default.
• W2890775821 hasAuthorship W2890775821A5055232373 @default.
• W2890775821 hasAuthorship W2890775821A5065914659 @default.
• W2890775821 hasAuthorship W2890775821A5068864334 @default.
• W2890775821 hasAuthorship W2890775821A5082847955 @default.
• W2890775821 hasBestOaLocation W28907758211 @default.
• W2890775821 hasConcept C105795698 @default.
• W2890775821 hasConcept C126322002 @default.
• W2890775821 hasConcept C159654299 @default.
• W2890775821 hasConcept C203014093 @default.
• W2890775821 hasConcept C2778190748 @default.
• W2890775821 hasConcept C2779134260 @default.
• W2890775821 hasConcept C2780441014 @default.
• W2890775821 hasConcept C2780868878 @default.
• W2890775821 hasConcept C33923547 @default.
• W2890775821 hasConcept C535046627 @default.
• W2890775821 hasConcept C71924100 @default.
• W2890775821 hasConceptScore W2890775821C105795698 @default.
• W2890775821 hasConceptScore W2890775821C126322002 @default.
• W2890775821 hasConceptScore W2890775821C159654299 @default.
• W2890775821 hasConceptScore W2890775821C203014093 @default.
• W2890775821 hasConceptScore W2890775821C2778190748 @default.
• W2890775821 hasConceptScore W2890775821C2779134260 @default.
• W2890775821 hasConceptScore W2890775821C2780441014 @default.
• W2890775821 hasConceptScore W2890775821C2780868878 @default.
• W2890775821 hasConceptScore W2890775821C33923547 @default.
• W2890775821 hasConceptScore W2890775821C535046627 @default.
• W2890775821 hasConceptScore W2890775821C71924100 @default.
• W2890775821 hasFunder F4320334659 @default.
• W2890775821 hasLocation W28907758211 @default.
• W2890775821 hasLocation W28907758212 @default.
• W2890775821 hasLocation W28907758213 @default.
• W2890775821 hasLocation W28907758214 @default.
• W2890775821 hasLocation W28907758215 @default.
• W2890775821 hasLocation W28907758216 @default.
• W2890775821 hasOpenAccess W2890775821 @default.
• W2890775821 hasPrimaryLocation W28907758211 @default.
• W2890775821 hasRelatedWork W1521318012 @default.
• W2890775821 hasRelatedWork W1768235319 @default.
• W2890775821 hasRelatedWork W1971717439 @default.
• W2890775821 hasRelatedWork W2073892499 @default.
• W2890775821 hasRelatedWork W2102187250 @default.
• W2890775821 hasRelatedWork W2408781296 @default.
• W2890775821 hasRelatedWork W3000595041 @default.
• W2890775821 hasRelatedWork W3045746510 @default.
• W2890775821 hasRelatedWork W3115726188 @default.
• W2890775821 hasRelatedWork W3164788651 @default.
• W2890775821 isParatext "false" @default.
• W2890775821 isRetracted "false" @default.
• W2890775821 magId "2890775821" @default.
• W2890775821 workType "article" @default.