Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890775888> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2890775888 abstract "11055 Background: The optimal management of malignant phyllod tumors (MPT) is poorly documented. Objective:To study the characteristics and outcome of MPT patients (pts). Methods: Retrospective study from the nation-wide French sarcoma network (NetSarc) from 2000 to 2016. Inclusion criteria was central pathological review of MPT. End-points were local recurrence-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS). Results: 212 pts, from 13 centers, were included. Median age was 52.8 years (range: 16.8 - 90.5). All localized MPT pts (96.7%) underwent surgery with 41.4% of mastectomy. The median size was 5.8 cm (range: 1.5 - 30). R1/R2 resection was achieved in 40.1% pts (26.9% 1-2 mm margin, 12.2% 3-7 mm, 20.3% ≥8 mm), with 44.8% of second surgery (SS) for a final mastectomy rate of 72.6%. Presurgical biopsy was performed in 86.3% and associated with R0 resection ( p=0.044) and better LRFS ( p=0.012). Median follow-up was 4.1 years (range 0-14.8) and revealed 34 (16.6%), 48 (22.9%), 44 (20.8%) events for LRFS, MFS and OS, respectively. The 2-year OS rate was 89%. Prognostic factors found in multivariate analysis are presented in Table 1. Wider margins (≥8mm) were not associated with better outcomes. Adjuvant radiotherapy and chemotherapy were performed in 43.6% and 13.3% respectively and associated with longer LRFS, not significant in multivariate analysis. Conclusions: Mastectomy is associated with better local control, but not with MFS and OS. Age, tumor necrosis and metastatic disease are associated with poor prognosis in MPT pts. Our study suggests that margins of 3 mm are necessary and sufficient for the surgical management of MPT and emphasizes the importance of SS to obtain clear margins. [Table: see text]" @default.
- W2890775888 created "2018-09-27" @default.
- W2890775888 creator A5010459987 @default.
- W2890775888 creator A5020342097 @default.
- W2890775888 creator A5026883860 @default.
- W2890775888 creator A5029151830 @default.
- W2890775888 creator A5031987093 @default.
- W2890775888 creator A5037214360 @default.
- W2890775888 creator A5042202815 @default.
- W2890775888 creator A5045172802 @default.
- W2890775888 creator A5048961826 @default.
- W2890775888 creator A5054992803 @default.
- W2890775888 creator A5057994171 @default.
- W2890775888 creator A5066286234 @default.
- W2890775888 creator A5072757261 @default.
- W2890775888 creator A5079866128 @default.
- W2890775888 creator A5082347575 @default.
- W2890775888 creator A5085647218 @default.
- W2890775888 creator A5086224635 @default.
- W2890775888 creator A5088161209 @default.
- W2890775888 creator A5089578640 @default.
- W2890775888 creator A5091721810 @default.
- W2890775888 date "2017-05-20" @default.
- W2890775888 modified "2023-10-17" @default.
- W2890775888 title "Outcome of 212 malignant phyllod tumor patients: A retrospective study from the French Sarcoma Group (GSF-GETO)." @default.
- W2890775888 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.11055" @default.
- W2890775888 hasPublicationYear "2017" @default.
- W2890775888 type Work @default.
- W2890775888 sameAs 2890775888 @default.
- W2890775888 citedByCount "0" @default.
- W2890775888 crossrefType "journal-article" @default.
- W2890775888 hasAuthorship W2890775888A5010459987 @default.
- W2890775888 hasAuthorship W2890775888A5020342097 @default.
- W2890775888 hasAuthorship W2890775888A5026883860 @default.
- W2890775888 hasAuthorship W2890775888A5029151830 @default.
- W2890775888 hasAuthorship W2890775888A5031987093 @default.
- W2890775888 hasAuthorship W2890775888A5037214360 @default.
- W2890775888 hasAuthorship W2890775888A5042202815 @default.
- W2890775888 hasAuthorship W2890775888A5045172802 @default.
- W2890775888 hasAuthorship W2890775888A5048961826 @default.
- W2890775888 hasAuthorship W2890775888A5054992803 @default.
- W2890775888 hasAuthorship W2890775888A5057994171 @default.
- W2890775888 hasAuthorship W2890775888A5066286234 @default.
- W2890775888 hasAuthorship W2890775888A5072757261 @default.
- W2890775888 hasAuthorship W2890775888A5079866128 @default.
- W2890775888 hasAuthorship W2890775888A5082347575 @default.
- W2890775888 hasAuthorship W2890775888A5085647218 @default.
- W2890775888 hasAuthorship W2890775888A5086224635 @default.
- W2890775888 hasAuthorship W2890775888A5088161209 @default.
- W2890775888 hasAuthorship W2890775888A5089578640 @default.
- W2890775888 hasAuthorship W2890775888A5091721810 @default.
- W2890775888 hasConcept C126322002 @default.
- W2890775888 hasConcept C142724271 @default.
- W2890775888 hasConcept C143998085 @default.
- W2890775888 hasConcept C167135981 @default.
- W2890775888 hasConcept C2778256501 @default.
- W2890775888 hasConcept C71924100 @default.
- W2890775888 hasConceptScore W2890775888C126322002 @default.
- W2890775888 hasConceptScore W2890775888C142724271 @default.
- W2890775888 hasConceptScore W2890775888C143998085 @default.
- W2890775888 hasConceptScore W2890775888C167135981 @default.
- W2890775888 hasConceptScore W2890775888C2778256501 @default.
- W2890775888 hasConceptScore W2890775888C71924100 @default.
- W2890775888 hasLocation W28907758881 @default.
- W2890775888 hasOpenAccess W2890775888 @default.
- W2890775888 hasPrimaryLocation W28907758881 @default.
- W2890775888 hasRelatedWork W1949339700 @default.
- W2890775888 hasRelatedWork W2004692040 @default.
- W2890775888 hasRelatedWork W2006880031 @default.
- W2890775888 hasRelatedWork W2041897724 @default.
- W2890775888 hasRelatedWork W2045991305 @default.
- W2890775888 hasRelatedWork W2409665301 @default.
- W2890775888 hasRelatedWork W2470191034 @default.
- W2890775888 hasRelatedWork W2525473634 @default.
- W2890775888 hasRelatedWork W2587595198 @default.
- W2890775888 hasRelatedWork W2602689510 @default.
- W2890775888 hasRelatedWork W2603972347 @default.
- W2890775888 hasRelatedWork W2790645241 @default.
- W2890775888 hasRelatedWork W2808946203 @default.
- W2890775888 hasRelatedWork W2889956456 @default.
- W2890775888 hasRelatedWork W2892288192 @default.
- W2890775888 hasRelatedWork W2970136114 @default.
- W2890775888 hasRelatedWork W3008416135 @default.
- W2890775888 hasRelatedWork W3080761830 @default.
- W2890775888 hasRelatedWork W3089061388 @default.
- W2890775888 hasRelatedWork W3158636329 @default.
- W2890775888 isParatext "false" @default.
- W2890775888 isRetracted "false" @default.
- W2890775888 magId "2890775888" @default.
- W2890775888 workType "article" @default.