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• W2890779838 abstract "e17052 Background: Sertoli Leydig cell tumors (SLCT) of the ovary are rare, and usually present as progressive virilization in women in their second to third decade of life. Less than 10% of patients are reportedly older than age 50. Methods: A retrospective review was performed of all cases of histologically proven ovarian SLCT diagnosed at a tertiary care institution between 1990 -2014. Results: Of the 16 patients diagnosed with SCLT over a 24-year period, nine patients (56%) were postmenopausal at the time of diagnosis with a median age of 52.5 years (IQR = 39.7 years). These 9 patients had a median interval of 14.7 years (IQR = 15) since the onset of menopause. Hyperandrogenism was a presenting feature in only 5 of 16 (31%) [median age of 49 (IQR = 26.5)] whereas postmenopausal bleeding was noted in 2 of 16 (12%). Only 3 of the patients with hyperandrogenism had preoperative hormonal assays confirming elevated total testosterone. Nine patients (56%), presented with vague symptoms of abdominal pain or bloating and were noted to have pelvic masses that were diagnosed as SLCT at the time of surgical removal. At diagnosis, tumor grade varied from well-differentiated to poorly-differentiated lesions. Nine lesions (56%) were of intermediate differentiation, and 8 patients (15%) received adjuvant chemotherapy. The decision to give adjuvant treatment was made for cases of higher than stage IA cancer, cases where concurrent tumors were identified on the surgical specimen, or in cases of poor tumor differentiation. Disease free survival over a median followup of 31.5 months (IQR = 73.5 months) was 100%. At the time of this study, all patients are alive with no recurrences with the exception of one who died from unrelated causes. Conclusions: Our patient population with SLCT was noticeably older than what has been described in literature, with greater than 50% being postmenopausal. To the best of our knowledge, this is the largest case series of postmenopausal patients with SLCT. Features of androgen excess and abnormal bleeding were evident in only a small sub-group. While the definitive management approach to SLCT remains controversial and varied, prognosis following definitive surgery and risk of recurrence are reassuring." @default.
• W2890779838 created "2018-09-27" @default.
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• W2890779838 date "2016-05-20" @default.
• W2890779838 modified "2023-09-26" @default.
• W2890779838 title "Ovarian Sertoli Leydig cell tumors: a single institution series of predominantly postmenopausal women." @default.
• W2890779838 doi "https://doi.org/10.1200/jco.2016.34.15_suppl.e17052" @default.
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