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• W2890780049 endingPage "e12955" @default.
• W2890780049 startingPage "e12955" @default.
• W2890780049 abstract "Activation of the Raf/MEK/ERK cascade is required for efficient propagation of several RNA and DNA viruses, including human respiratory syncytial virus (RSV). In RSV infection, activation of the Raf/MEK/ERK cascade is biphasic. An early induction within minutes after infection is associated with viral attachment. Subsequently, a second activation occurs with, so far, unknown function in the viral life cycle. In this study, we aimed to characterise the role of Raf/MEK/ERK-mediated signalling during ongoing RSV infection. Our data show that inhibition of the kinase MEK after the virus has been internalised results in a reduction of viral titers. Further functional investigations revealed that the late-stage activation of ERK is required for a specific step in RSV replication, namely, the secretory transport of the RSV fusion protein F. Thus, MEK inhibition resulted in impaired surface accumulation of the F protein. F protein surface expression is essential for efficient replication as it is involved in viral filament formation, cell fusion, and viral transmission. In summary, we provide detailed insights of how host cell signalling interferes with RSV replication and identified the Raf/MEK/ERK kinase cascade as potential target for novel anti-RSV strategies." @default.
• W2890780049 created "2018-09-27" @default.
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• W2890780049 date "2018-10-23" @default.
• W2890780049 modified "2023-10-07" @default.
• W2890780049 title "Late activation of the<scp>Raf/MEK/ERK</scp>pathway is required for translocation of the respiratory syncytial virus<scp>F</scp>protein to the plasma membrane and efficient viral replication" @default.
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• W2890780049 doi "https://doi.org/10.1111/cmi.12955" @default.
• W2890780049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30223301" @default.
• W2890780049 hasPublicationYear "2018" @default.
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