Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890780729> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W2890780729 abstract "e15780 Background: Approximately 50% of all patients with pancreatic ductal adenocarcinoma (PDA) develop diabetes mellitus (DM) prior to cancer diagnosis. Targeted screening for PDA among those with new-onset diabetes may allow earlier diagnosis. We sought to develop and validate a PDA risk prediction model to identify high-risk individuals among those with new-onset diabetes. Methods: We conducted a retrospective cohort study in a population representative database from the UK. Individuals with incident diabetes after the age of 35 and ≥3 years of follow-up after DM diagnosis were eligible for inclusion. Candidate predictors consisted of epidemiological and clinical characteristics available at the time of diabetes diagnosis. Variables with p-value<0.25 in the univariable analyses were further evaluated using backward stepwise approach. Model discrimination was assessed using ROC curve analysis. Calibration was evaluated using the Hosmer–Lemeshow test. Results were internally validated using a bootstrapping procedure. Results: The study included 109,385 patients with new-onset diabetes. Among them, 390 (0.4%) were diagnosed with PDA within 3 years. The final model (AUC 0.82, 95% CI: 0.75-0.89) included age, BMI, BMI change, smoking, HbA1C, cholesterol, hemoglobin, creatinine and alkaline phosphatase, and use of PPI and anti-diabetic medication. Bootstrapping validation showed negligible optimism. If the predicted risk threshold for definitive PDA screening was set at 1% over 3 years, only 6.19% of the new-onset diabetes population would undergo definitive screening, and the corresponding sensitivity, specificity and positive predictive value would be 44.7%, 94.0%, and 2.6% respectively. Conclusions: A risk model based on widely available clinical parameters can help target PDA screening in patients with new-onset diabetes." @default.
- W2890780729 created "2018-09-27" @default.
- W2890780729 creator A5007502154 @default.
- W2890780729 creator A5023539776 @default.
- W2890780729 creator A5041384981 @default.
- W2890780729 creator A5042304706 @default.
- W2890780729 creator A5046961512 @default.
- W2890780729 creator A5055266545 @default.
- W2890780729 creator A5079147453 @default.
- W2890780729 creator A5083781305 @default.
- W2890780729 date "2017-05-20" @default.
- W2890780729 modified "2023-10-18" @default.
- W2890780729 title "A clinical prediction model to assess risk for pancreatic cancer among patients with new-onset diabetes." @default.
- W2890780729 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e15780" @default.
- W2890780729 hasPublicationYear "2017" @default.
- W2890780729 type Work @default.
- W2890780729 sameAs 2890780729 @default.
- W2890780729 citedByCount "0" @default.
- W2890780729 crossrefType "journal-article" @default.
- W2890780729 hasAuthorship W2890780729A5007502154 @default.
- W2890780729 hasAuthorship W2890780729A5023539776 @default.
- W2890780729 hasAuthorship W2890780729A5041384981 @default.
- W2890780729 hasAuthorship W2890780729A5042304706 @default.
- W2890780729 hasAuthorship W2890780729A5046961512 @default.
- W2890780729 hasAuthorship W2890780729A5055266545 @default.
- W2890780729 hasAuthorship W2890780729A5079147453 @default.
- W2890780729 hasAuthorship W2890780729A5083781305 @default.
- W2890780729 hasConcept C112930515 @default.
- W2890780729 hasConcept C121608353 @default.
- W2890780729 hasConcept C126322002 @default.
- W2890780729 hasConcept C134018914 @default.
- W2890780729 hasConcept C143998085 @default.
- W2890780729 hasConcept C2780210213 @default.
- W2890780729 hasConcept C2986432223 @default.
- W2890780729 hasConcept C555293320 @default.
- W2890780729 hasConcept C71924100 @default.
- W2890780729 hasConceptScore W2890780729C112930515 @default.
- W2890780729 hasConceptScore W2890780729C121608353 @default.
- W2890780729 hasConceptScore W2890780729C126322002 @default.
- W2890780729 hasConceptScore W2890780729C134018914 @default.
- W2890780729 hasConceptScore W2890780729C143998085 @default.
- W2890780729 hasConceptScore W2890780729C2780210213 @default.
- W2890780729 hasConceptScore W2890780729C2986432223 @default.
- W2890780729 hasConceptScore W2890780729C555293320 @default.
- W2890780729 hasConceptScore W2890780729C71924100 @default.
- W2890780729 hasLocation W28907807291 @default.
- W2890780729 hasOpenAccess W2890780729 @default.
- W2890780729 hasPrimaryLocation W28907807291 @default.
- W2890780729 isParatext "false" @default.
- W2890780729 isRetracted "false" @default.
- W2890780729 magId "2890780729" @default.
- W2890780729 workType "article" @default.