Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890781138> ?p ?o ?g. }
- W2890781138 endingPage "5359" @default.
- W2890781138 startingPage "5347" @default.
- W2890781138 abstract "There is currently much interest in cancer cell targeting and tumor penetrating for research and therapeutic purposes.To improve targeting delivery of antitumor drugs to gastric cancer, in this study, a tumor-targeting biocompatible drug delivery system derived from erythrocyte membrane for delivering paclitaxel (PTX) was constructed.Erythrocyte membrane of human red blood cells (RBCs) were used for preparing of erythrocyte membrane-derived vesicles. 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(maleimide[polyethylene glycol]-3400) (DSPE-PEG-MAL), a phospholipid derivative, was used to insert tumor-targeting molecular into erythrocyte membrane-derived vesicles. A lipid insertion method was used to functionalize these vesicles without the need for direct chemical conjugation. Furthermore, a tumor-penetrating bispecific recombinant protein named anti-EGFR-iRGD was used for the first time in this work to enable nanosystem to target and penetrate efficiently into the tumor site.Paclitaxel (PTX)-loaded anti-EGFR-iRGD-modified erythrocyte membrane nano-system (anti-EGFR-iRGD-RBCm-PTX, abbreviated to PRP) were manufactured. PRP was spheroid, uniformly size, about 171.7±4.7 nm in average, could be stable in vitro for 8 days, and released PTX in a biphasic pattern. PRP showed comparable cytotoxicity toward human gastric cancer cells in vitro. In vivo studies showed that, PRP accumulated in tumor site within 2 h of administration, lasted longer than 48 h, and the tumor volume was reduced 61% by PRP treatment in Balb/c nude mice, without causing severe side effects.PRP has potential applications in cancer treatment and as an adjunct for other anticancer strategies." @default.
- W2890781138 created "2018-09-27" @default.
- W2890781138 creator A5004716187 @default.
- W2890781138 creator A5010366857 @default.
- W2890781138 creator A5010877903 @default.
- W2890781138 creator A5013653434 @default.
- W2890781138 creator A5016481331 @default.
- W2890781138 creator A5033420311 @default.
- W2890781138 creator A5056700500 @default.
- W2890781138 creator A5059386730 @default.
- W2890781138 creator A5064530138 @default.
- W2890781138 creator A5064633706 @default.
- W2890781138 creator A5077730407 @default.
- W2890781138 creator A5079009219 @default.
- W2890781138 creator A5085558954 @default.
- W2890781138 date "2018-09-01" @default.
- W2890781138 modified "2023-10-11" @default.
- W2890781138 title "Lipid insertion enables targeted functionalization of paclitaxel-loaded erythrocyte membrane nanosystem by tumor-penetrating bispecific recombinant protein" @default.
- W2890781138 cites W1964299172 @default.
- W2890781138 cites W1977479596 @default.
- W2890781138 cites W1980052502 @default.
- W2890781138 cites W1992820085 @default.
- W2890781138 cites W2002939906 @default.
- W2890781138 cites W2004934153 @default.
- W2890781138 cites W2005033237 @default.
- W2890781138 cites W2006371280 @default.
- W2890781138 cites W2007102329 @default.
- W2890781138 cites W2010463588 @default.
- W2890781138 cites W2020794186 @default.
- W2890781138 cites W2021163996 @default.
- W2890781138 cites W2026185209 @default.
- W2890781138 cites W2032760352 @default.
- W2890781138 cites W2040242287 @default.
- W2890781138 cites W2041998484 @default.
- W2890781138 cites W2042634738 @default.
- W2890781138 cites W2044332216 @default.
- W2890781138 cites W2049772098 @default.
- W2890781138 cites W2053929414 @default.
- W2890781138 cites W2057632167 @default.
- W2890781138 cites W2061775664 @default.
- W2890781138 cites W2064551506 @default.
- W2890781138 cites W2065302847 @default.
- W2890781138 cites W2069261831 @default.
- W2890781138 cites W2072554913 @default.
- W2890781138 cites W2082511916 @default.
- W2890781138 cites W2086367502 @default.
- W2890781138 cites W2086856055 @default.
- W2890781138 cites W2105365201 @default.
- W2890781138 cites W2114235650 @default.
- W2890781138 cites W211488679 @default.
- W2890781138 cites W2127933607 @default.
- W2890781138 cites W2134812356 @default.
- W2890781138 cites W2140502432 @default.
- W2890781138 cites W2145479354 @default.
- W2890781138 cites W2152143390 @default.
- W2890781138 cites W2159902976 @default.
- W2890781138 cites W2164841185 @default.
- W2890781138 cites W2213012239 @default.
- W2890781138 cites W2272984102 @default.
- W2890781138 cites W2314906766 @default.
- W2890781138 cites W2330461172 @default.
- W2890781138 cites W2344860565 @default.
- W2890781138 cites W2399178805 @default.
- W2890781138 cites W2402357292 @default.
- W2890781138 cites W2495773034 @default.
- W2890781138 cites W2735497375 @default.
- W2890781138 cites W60886306 @default.
- W2890781138 cites W644059216 @default.
- W2890781138 cites W974909913 @default.
- W2890781138 doi "https://doi.org/10.2147/ijn.s165109" @default.
- W2890781138 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6141126" @default.
- W2890781138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254439" @default.
- W2890781138 hasPublicationYear "2018" @default.
- W2890781138 type Work @default.
- W2890781138 sameAs 2890781138 @default.
- W2890781138 citedByCount "43" @default.
- W2890781138 countsByYear W28907811382019 @default.
- W2890781138 countsByYear W28907811382020 @default.
- W2890781138 countsByYear W28907811382021 @default.
- W2890781138 countsByYear W28907811382022 @default.
- W2890781138 countsByYear W28907811382023 @default.
- W2890781138 crossrefType "journal-article" @default.
- W2890781138 hasAuthorship W2890781138A5004716187 @default.
- W2890781138 hasAuthorship W2890781138A5010366857 @default.
- W2890781138 hasAuthorship W2890781138A5010877903 @default.
- W2890781138 hasAuthorship W2890781138A5013653434 @default.
- W2890781138 hasAuthorship W2890781138A5016481331 @default.
- W2890781138 hasAuthorship W2890781138A5033420311 @default.
- W2890781138 hasAuthorship W2890781138A5056700500 @default.
- W2890781138 hasAuthorship W2890781138A5059386730 @default.
- W2890781138 hasAuthorship W2890781138A5064530138 @default.
- W2890781138 hasAuthorship W2890781138A5064633706 @default.
- W2890781138 hasAuthorship W2890781138A5077730407 @default.
- W2890781138 hasAuthorship W2890781138A5079009219 @default.
- W2890781138 hasAuthorship W2890781138A5085558954 @default.
- W2890781138 hasBestOaLocation W28907811381 @default.
- W2890781138 hasConcept C109316439 @default.
- W2890781138 hasConcept C121608353 @default.