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- W2890781875 abstract "Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. The current study aimed to investigate potential antiallergic properties of hUC-MSCs in mice with ovalbumin (OVA)-induced food allergy. Administration of hUC-MSCs cells intraperitoneally combined with oral gavage of the culture medium significantly alleviated OVA-induced diarrhea symptoms. Additionally, this treatment significantly decreased IgE levels and the percentage of T helper 2 cells in the blood, which were increased in mice with OVA-induced food allergy. The mRNA levels of the inflammatory cytokines interleukin-4 and tumor necrosis factor-α, and inflammatory cell infiltration in mouse colons were significantly decreased in hUC-MSCs-treated animals compared with mice with OVA-induced food allergy. Goblet cells were detected in colons of allergy-induced mice and their numbers were reduced following treatment with hUC-MSCs. In addition, treatment with hUC-MSCs reestablished the gut flora. The results revealed that hUC-MSCs may have a potential application in food allergy therapy." @default.
- W2890781875 created "2018-09-27" @default.
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- W2890781875 date "2018-09-19" @default.
- W2890781875 modified "2023-10-14" @default.
- W2890781875 title "Human umbilical cord‑derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice" @default.
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- W2890781875 doi "https://doi.org/10.3892/etm.2018.6763" @default.
- W2890781875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6256969" @default.
- W2890781875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30546392" @default.
- W2890781875 hasPublicationYear "2018" @default.