FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890782809> ?p ?o ?g. }

• W2890782809 endingPage "472" @default.
• W2890782809 startingPage "458" @default.
• W2890782809 abstract "Objective To query the transcript-level changes in the medial and lateral tibial plateau cartilage in tandem with obesity in patients with end-stage osteoarthritis (OA). Design Cartilage was obtained from 23 patients (20 obese [body mass index > 30 kg/m 2 ], 3 overweight [body mass index < 30 kg/m 2 ]) at the time of total knee replacement. Cartilage integrity was assessed using Outerbridge scale, while radiographic changes were scored on preoperative X-rays using Kellgren-Lawrence (K-L) classification. RNA was probed for differentially expressed transcripts between medial and lateral compartments using Affymetrix Gene 2.0 ST Array and validated via real-time polymerase chain reaction. Gene ontology and pathway analyses were also queried. Results Scoring of cartilage integrity by the Outerbridge scale indicated that the medial and lateral compartments were similar, while scoring by the K-L classification indicated that the medial compartment was more severely damaged than the lateral compartment. We observed a distinct transcript profile with >50% of transcripts unique between medial and lateral compartments. MMP13 and COL2A1 were more highly expressed in medial versus lateral compartment. Polymerase chain reaction confirmed expression of 4 differentially expressed transcripts. Numerous transcripts, biological processes, and pathways were significantly different between overweight and obese patients with a differential response of obesity on medial and lateral compartments. Conclusions Our findings support molecular differences between medial and lateral compartments reflective of the greater severity of OA in the medial compartment. The K-L system better reflected the molecular results than did the Outerbridge. Moreover, the molecular effect of obesity was different between the medial and lateral compartments of the same knee plausibly reflecting the molecular effects of differential biomechanical loading." @default.
• W2890782809 created "2018-09-27" @default.
• W2890782809 creator A5015288124 @default.
• W2890782809 creator A5023251060 @default.
• W2890782809 creator A5036234028 @default.
• W2890782809 creator A5044520292 @default.
• W2890782809 creator A5056468741 @default.
• W2890782809 creator A5063185663 @default.
• W2890782809 creator A5081428512 @default.
• W2890782809 creator A5082172901 @default.
• W2890782809 date "2018-09-03" @default.
• W2890782809 modified "2023-10-14" @default.
• W2890782809 title "A Microarray Study of Articular Cartilage in Relation to Obesity and Severity of Knee Osteoarthritis" @default.
• W2890782809 cites W1563056600 @default.
• W2890782809 cites W1576883902 @default.
• W2890782809 cites W1853244388 @default.
• W2890782809 cites W1967057044 @default.
• W2890782809 cites W1967601085 @default.
• W2890782809 cites W1973937375 @default.
• W2890782809 cites W1975396356 @default.
• W2890782809 cites W1977082334 @default.
• W2890782809 cites W1982485066 @default.
• W2890782809 cites W1986442052 @default.
• W2890782809 cites W1988650452 @default.
• W2890782809 cites W1988682659 @default.
• W2890782809 cites W1990844960 @default.
• W2890782809 cites W1993770134 @default.
• W2890782809 cites W1996197049 @default.
• W2890782809 cites W199753275 @default.
• W2890782809 cites W2005626023 @default.
• W2890782809 cites W2012519628 @default.
• W2890782809 cites W2012997419 @default.
• W2890782809 cites W2020541351 @default.
• W2890782809 cites W2023156173 @default.
• W2890782809 cites W2026214364 @default.
• W2890782809 cites W2044924856 @default.
• W2890782809 cites W2048826456 @default.
• W2890782809 cites W2056566535 @default.
• W2890782809 cites W2057088909 @default.
• W2890782809 cites W2059971032 @default.
• W2890782809 cites W2068858277 @default.
• W2890782809 cites W2068944823 @default.
• W2890782809 cites W2070408281 @default.
• W2890782809 cites W2072740771 @default.
• W2890782809 cites W2073456348 @default.
• W2890782809 cites W2093340955 @default.
• W2890782809 cites W2094908805 @default.
• W2890782809 cites W2106582491 @default.
• W2890782809 cites W2123900064 @default.
• W2890782809 cites W2151965562 @default.
• W2890782809 cites W2154679095 @default.
• W2890782809 cites W2162255425 @default.
• W2890782809 cites W2168221175 @default.
• W2890782809 cites W2168573645 @default.
• W2890782809 cites W2170261794 @default.
• W2890782809 cites W2295897848 @default.
• W2890782809 cites W2370417321 @default.
• W2890782809 cites W2395594709 @default.
• W2890782809 cites W2410484497 @default.
• W2890782809 cites W2769386620 @default.
• W2890782809 cites W2803590439 @default.
• W2890782809 cites W3025829724 @default.
• W2890782809 cites W44356346 @default.
• W2890782809 doi "https://doi.org/10.1177/1947603518796122" @default.
• W2890782809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7488940" @default.
• W2890782809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30173558" @default.
• W2890782809 hasPublicationYear "2018" @default.
• W2890782809 type Work @default.
• W2890782809 sameAs 2890782809 @default.
• W2890782809 citedByCount "10" @default.
• W2890782809 countsByYear W28907828092020 @default.
• W2890782809 countsByYear W28907828092021 @default.
• W2890782809 countsByYear W28907828092022 @default.
• W2890782809 crossrefType "journal-article" @default.
• W2890782809 hasAuthorship W2890782809A5015288124 @default.
• W2890782809 hasAuthorship W2890782809A5023251060 @default.
• W2890782809 hasAuthorship W2890782809A5036234028 @default.
• W2890782809 hasAuthorship W2890782809A5044520292 @default.
• W2890782809 hasAuthorship W2890782809A5056468741 @default.
• W2890782809 hasAuthorship W2890782809A5063185663 @default.
• W2890782809 hasAuthorship W2890782809A5081428512 @default.
• W2890782809 hasAuthorship W2890782809A5082172901 @default.
• W2890782809 hasBestOaLocation W28907828091 @default.
• W2890782809 hasConcept C105702510 @default.
• W2890782809 hasConcept C111368507 @default.
• W2890782809 hasConcept C127313418 @default.
• W2890782809 hasConcept C142724271 @default.
• W2890782809 hasConcept C203635412 @default.
• W2890782809 hasConcept C204787440 @default.
• W2890782809 hasConcept C2776164576 @default.
• W2890782809 hasConcept C2780221984 @default.
• W2890782809 hasConcept C2780550940 @default.
• W2890782809 hasConcept C71924100 @default.
• W2890782809 hasConceptScore W2890782809C105702510 @default.
• W2890782809 hasConceptScore W2890782809C111368507 @default.
• W2890782809 hasConceptScore W2890782809C127313418 @default.
• W2890782809 hasConceptScore W2890782809C142724271 @default.
• W2890782809 hasConceptScore W2890782809C203635412 @default.

• next