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- W2890788715 abstract "e23215 Background: FDG-PET/CT is widely used for the detection of primary breast cancer and metastasis, although its clinical significance is somewhat restricted to appropriate higher-risk populations. We attempted to apply maximum uptake values (SUV max ) of FDG-PET/CT to assess the malignant potential of breast cancer before surgery. Methods: We retrospectively reviewed 187 consecutive patients with invasive breast cancer and no distant metastasis recruited from 2009 to 2011 in our hospital who underwent PET/CT before surgery, and determined the representative PET imaging features by SUV max . Correlation of SUV max with several clinicopathological factors was evaluated by regression analysis. Relapse-free survival (RFS) and overall survival (OS) were compared among these factors and SUV max using univariate and multivariate Cox analysis, Kaplan-Meier curves, and log-rank tests. Results: All patients were women of median age 60 years. The median follow-up period was 72 months. A logarithmic transformation was applied to SUV max , which resulted in exclusion of 32 patients with no FDG uptake on PET/CT. Regression analysis revealed that SUV max significantly correlated with ER (P = 0.0138), HER2 (P = 0.0153), lymph node metastasis (P < 0.0001), and tumor size (P < 0.0001). Multivariate analysis showed that tumor size was a significant independent factor. As regression analysis showed a strong correlation between SUV max and tumor size < 5 cm (P < 0.0001), the 11 patients with tumor > 5 cm were excluded. Concerning the malignant potential of tumors, RFS was evaluated by univariate analysis whereby the median log SUV max (0.6) was the only significantly independent factor to predict recurrence (P = 0.045). Patients with log SUV max > 0.6 showed poor RFS (11 patients with recurrence) compared with log SUV max < 0.6 (2 patients with recurrence) (P = 0.0064). OS showed no significant correlation. Conclusions: PET/CT is potentially a valuable modality to predict tumor recurrence in patients with breast cancer whose tumor size is < 5 cm and demonstrates uptake before surgery." @default.
- W2890788715 created "2018-09-27" @default.
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- W2890788715 date "2017-05-20" @default.
- W2890788715 modified "2023-09-27" @default.
- W2890788715 title "Clinical significance of FDG-PET/CT in assessment of recurrence in breast cancer patients before surgery." @default.
- W2890788715 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e23215" @default.
- W2890788715 hasPublicationYear "2017" @default.
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