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- W2890788959 abstract "The single pass, transmembrane proteins of the cadherin family have been appreciated as important proteins that regulate intercellular adhesion. In addition to this critical function, cadherins contribute to important signalling events that control cellular homeostasis. Many examples exist of classical, desmosomal and atypical cadherins participating in the regulation of signalling events that control homeostatic functions in cells. Much of the work on cadherin mediated signalling focuses on classical cadherins or on specific disease states such as pemphigus vulgaris. Cadherin mediated signalling has been shown to play critical roles during development, in proliferation, apoptosis, disease pathobiology and beyond. It is becoming increasingly clear that cadherins operate through a range of molecular mechanisms. The diversity of pathways and cellular functions regulated by cadherins suggests that we have only scratched the surface in terms of the roles that these versatile proteins play in signalling and cellular function." @default.
- W2890788959 created "2018-09-27" @default.
- W2890788959 creator A5015695619 @default.
- W2890788959 creator A5052542632 @default.
- W2890788959 creator A5088545837 @default.
- W2890788959 date "2018-08-08" @default.
- W2890788959 modified "2023-10-14" @default.
- W2890788959 title "Cadherins: cellular adhesive molecules serving as signalling mediators" @default.
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- W2890788959 doi "https://doi.org/10.1113/jp275328" @default.
- W2890788959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6117591" @default.
- W2890788959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29968384" @default.
- W2890788959 hasPublicationYear "2018" @default.
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