FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890789664> ?p ?o ?g. }

• W2890789664 abstract "6008 Background: We report on the first multi-centre randomized phase III trial of post-operative radiotherapy (PORT) vs post-operative chemo-RT (CRT) in high-risk cutaneous squamous cell carcinoma of the head and neck (cSCCHN) (NCT00193895). Methods: The primary objective was to determine whether there was a freedom from loco-regional relapse (FLRR) difference between patients randomly assigned to 60-66Gy (6-6.5 weeks) with or without weekly carboplatin (AUC 2) following resection of gross disease. Patients were stratified to high-risk nodal (either extracapsular nodal extension, intra-parotid nodal disease of any size or number, cervical nodal disease with ≥2 nodes or largest node > 3cm) or high-risk primary (T3-T4 or in-transit metastases). Patients with both features were stratified to the high-risk nodal group. Secondary objectives included disease-free survival (DFS), overall survival (OS) and acute & late toxicity (CTCAE V3). Results: 321 patients were randomly assigned between 2005-2014, with 11 not commencing treatment protocol due to disease progression or withdrawal of consent. Of the 310 patients commencing treatment protocol (157 RT and 153 CRT), 230 (74%) had high-risk nodal, 70 (22%) high-risk primary and 10 (3%) both. Median follow up was 60 months, median RT dose was 60Gy and 85% randomised to CRT completed 6 cycles of carboplatin. The 2- & 5-year FLRR (95% CI) for the RT arm was 88% (83-93%)/83% (77-90%) and for CRT 89% (84-94%)/87% (81-93%) (HR 0.85; 95%CI [0.46-1.55]; p = 0.59). The 2- & 5 year DFS (95% CI) for the RT arm was 78% (72-85%)/67% (60-76%) and for CRT 83% (77-89%)/73% (66-81%) (HR 0.85; 95%CI [0.55-1.29]; p = 0.43). The 2- & 5 year OS (95% CI) for the RT arm was 88% (83-93%)/76% (69-84%) and for CRT 88% (83-94%)/79% (72-86%) (HR 0.95; 95%CI [0.58-1.57]; p = 0.84). 134 (43%) experienced Grade 3/4 skin toxicity; 49% RT, 37% CRT (p = 0.039). 12 (3.9%) experienced Grade 3/4 subcutaneous fibrosis; 2.5% RT, 5.2% CRT. Conclusions: While surgery and PORT provided excellent FLRR with acceptable toxicity, the addition of weekly carboplatin did not improve outcomes in high-risk cSCCHN. Clinical trial information: NCT00193895." @default.
• W2890789664 created "2018-09-27" @default.
• W2890789664 creator A5005373482 @default.
• W2890789664 creator A5011352365 @default.
• W2890789664 creator A5013313611 @default.
• W2890789664 creator A5019143542 @default.
• W2890789664 creator A5022098864 @default.
• W2890789664 creator A5022236414 @default.
• W2890789664 creator A5022262400 @default.
• W2890789664 creator A5025328738 @default.
• W2890789664 creator A5033196836 @default.
• W2890789664 creator A5040134246 @default.
• W2890789664 creator A5041349919 @default.
• W2890789664 creator A5042517986 @default.
• W2890789664 creator A5060469120 @default.
• W2890789664 creator A5066843487 @default.
• W2890789664 creator A5074110746 @default.
• W2890789664 creator A5083599631 @default.
• W2890789664 creator A5090390499 @default.
• W2890789664 date "2017-05-20" @default.
• W2890789664 modified "2023-09-28" @default.
• W2890789664 title "Post-operative concurrent chemo-radiotherapy versus post-operative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck: A randomized phase III trial (Trans Tasman Radiation Oncology Group 05.01 Trial; POST study)." @default.
• W2890789664 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.6008" @default.
• W2890789664 hasPublicationYear "2017" @default.
• W2890789664 type Work @default.
• W2890789664 sameAs 2890789664 @default.
• W2890789664 citedByCount "6" @default.
• W2890789664 countsByYear W28907896642017 @default.
• W2890789664 countsByYear W28907896642018 @default.
• W2890789664 countsByYear W28907896642021 @default.
• W2890789664 crossrefType "journal-article" @default.
• W2890789664 hasAuthorship W2890789664A5005373482 @default.
• W2890789664 hasAuthorship W2890789664A5011352365 @default.
• W2890789664 hasAuthorship W2890789664A5013313611 @default.
• W2890789664 hasAuthorship W2890789664A5019143542 @default.
• W2890789664 hasAuthorship W2890789664A5022098864 @default.
• W2890789664 hasAuthorship W2890789664A5022236414 @default.
• W2890789664 hasAuthorship W2890789664A5022262400 @default.
• W2890789664 hasAuthorship W2890789664A5025328738 @default.
• W2890789664 hasAuthorship W2890789664A5033196836 @default.
• W2890789664 hasAuthorship W2890789664A5040134246 @default.
• W2890789664 hasAuthorship W2890789664A5041349919 @default.
• W2890789664 hasAuthorship W2890789664A5042517986 @default.
• W2890789664 hasAuthorship W2890789664A5060469120 @default.
• W2890789664 hasAuthorship W2890789664A5066843487 @default.
• W2890789664 hasAuthorship W2890789664A5074110746 @default.
• W2890789664 hasAuthorship W2890789664A5083599631 @default.
• W2890789664 hasAuthorship W2890789664A5090390499 @default.
• W2890789664 hasConcept C126322002 @default.
• W2890789664 hasConcept C141071460 @default.
• W2890789664 hasConcept C143998085 @default.
• W2890789664 hasConcept C168563851 @default.
• W2890789664 hasConcept C2776530083 @default.
• W2890789664 hasConcept C2776833033 @default.
• W2890789664 hasConcept C2910486316 @default.
• W2890789664 hasConcept C3018411727 @default.
• W2890789664 hasConcept C3019992690 @default.
• W2890789664 hasConcept C509974204 @default.
• W2890789664 hasConcept C71924100 @default.
• W2890789664 hasConceptScore W2890789664C126322002 @default.
• W2890789664 hasConceptScore W2890789664C141071460 @default.
• W2890789664 hasConceptScore W2890789664C143998085 @default.
• W2890789664 hasConceptScore W2890789664C168563851 @default.
• W2890789664 hasConceptScore W2890789664C2776530083 @default.
• W2890789664 hasConceptScore W2890789664C2776833033 @default.
• W2890789664 hasConceptScore W2890789664C2910486316 @default.
• W2890789664 hasConceptScore W2890789664C3018411727 @default.
• W2890789664 hasConceptScore W2890789664C3019992690 @default.
• W2890789664 hasConceptScore W2890789664C509974204 @default.
• W2890789664 hasConceptScore W2890789664C71924100 @default.
• W2890789664 hasLocation W28907896641 @default.
• W2890789664 hasOpenAccess W2890789664 @default.
• W2890789664 hasPrimaryLocation W28907896641 @default.
• W2890789664 isParatext "false" @default.
• W2890789664 isRetracted "false" @default.
• W2890789664 magId "2890789664" @default.
• W2890789664 workType "article" @default.