Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890790761> ?p ?o ?g. }
- W2890790761 endingPage "e0203560" @default.
- W2890790761 startingPage "e0203560" @default.
- W2890790761 abstract "The objective of the present study was to assess safety and immune responses in gilts after intradermal application of Porcilis® PRRS in two different application sites under field conditions. Forty-four gilts were allocated to one of three groups: Gilts of group 1 (n = 10) served as non-vaccinated controls, gilts of group 2 (n = 17) were vaccinated intradermally in the neck and gilts of group 3 (n = 17) received an intradermal vaccination in the perianal region. Clinical observations, local injection site reactions and histopathologic examination of the injection site were used for safety assessments. Frequency and degree of clinical signs were not significantly different between all three groups. Minor local reactions for both vaccination groups were observed; however, at 6, 7, 8, 9 and 15 days post-vaccination (dpv), the mean injection site reaction score was significantly lower in pigs vaccinated in the perianal region. In histopathologic examination, an extended inflammatory dimension was observed more frequently in pigs vaccinated in the neck. Blood samples were analyzed to quantify the post-vaccination humoral (ELISA and virus neutralization test) and cellular (IFN-γ ELISPOT) immune responses. PRRSV-specific antibodies were present in the serum of all vaccinated animals from 14 dpv onwards, whereas all control pigs remained negative throughout the study. Neutralizing antibody titers were significantly higher in pigs vaccinated in the perianal region at 28 dpv. At 14, 21 and 28 dpv, PRRSV-specific IFN-γ secreting cells were significantly increased in both vaccination groups compared to non-vaccinated gilts. Analysis of mean numbers of PRRSV-specific IFN-γ secreting cells did not result in statistically significant differences between both vaccination groups. The results of this study indicate that the perianal region is a safe alternative application site for intradermal vaccination of gilts with Porcilis PRRS. Furthermore, the intradermal application of Porcilis PRRS induced humoral and cellular immune responses independent of the administration site." @default.
- W2890790761 created "2018-09-27" @default.
- W2890790761 creator A5012857173 @default.
- W2890790761 creator A5020848133 @default.
- W2890790761 creator A5029719511 @default.
- W2890790761 creator A5043749174 @default.
- W2890790761 creator A5043850579 @default.
- W2890790761 creator A5045928207 @default.
- W2890790761 creator A5051227106 @default.
- W2890790761 creator A5060033325 @default.
- W2890790761 creator A5067081413 @default.
- W2890790761 creator A5078753791 @default.
- W2890790761 creator A5085332912 @default.
- W2890790761 date "2018-09-07" @default.
- W2890790761 modified "2023-10-05" @default.
- W2890790761 title "Safety and immune responses after intradermal application of Porcilis PRRS in either the neck or the perianal region" @default.
- W2890790761 cites W137726580 @default.
- W2890790761 cites W1969510874 @default.
- W2890790761 cites W1983921453 @default.
- W2890790761 cites W1985167539 @default.
- W2890790761 cites W1999423095 @default.
- W2890790761 cites W2005829501 @default.
- W2890790761 cites W2007107279 @default.
- W2890790761 cites W2012121871 @default.
- W2890790761 cites W2013406173 @default.
- W2890790761 cites W2019542752 @default.
- W2890790761 cites W2026666514 @default.
- W2890790761 cites W2027005967 @default.
- W2890790761 cites W2033745025 @default.
- W2890790761 cites W2033746467 @default.
- W2890790761 cites W2039544307 @default.
- W2890790761 cites W2040052608 @default.
- W2890790761 cites W2050984833 @default.
- W2890790761 cites W2052818607 @default.
- W2890790761 cites W2058927166 @default.
- W2890790761 cites W2067589660 @default.
- W2890790761 cites W2068230560 @default.
- W2890790761 cites W2073805518 @default.
- W2890790761 cites W2073857833 @default.
- W2890790761 cites W2074324405 @default.
- W2890790761 cites W2084775257 @default.
- W2890790761 cites W2085068888 @default.
- W2890790761 cites W2085703614 @default.
- W2890790761 cites W2090889765 @default.
- W2890790761 cites W2091576390 @default.
- W2890790761 cites W2104309725 @default.
- W2890790761 cites W2106908706 @default.
- W2890790761 cites W2125565720 @default.
- W2890790761 cites W2127899004 @default.
- W2890790761 cites W2128940814 @default.
- W2890790761 cites W2142214376 @default.
- W2890790761 cites W2146278938 @default.
- W2890790761 cites W2149383095 @default.
- W2890790761 cites W2151075263 @default.
- W2890790761 cites W2153733982 @default.
- W2890790761 cites W2157227966 @default.
- W2890790761 cites W2426643820 @default.
- W2890790761 cites W2532627188 @default.
- W2890790761 cites W2571365627 @default.
- W2890790761 cites W2594122149 @default.
- W2890790761 cites W2608721523 @default.
- W2890790761 cites W297534445 @default.
- W2890790761 doi "https://doi.org/10.1371/journal.pone.0203560" @default.
- W2890790761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128605" @default.
- W2890790761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192831" @default.
- W2890790761 hasPublicationYear "2018" @default.
- W2890790761 type Work @default.
- W2890790761 sameAs 2890790761 @default.
- W2890790761 citedByCount "12" @default.
- W2890790761 countsByYear W28907907612019 @default.
- W2890790761 countsByYear W28907907612020 @default.
- W2890790761 countsByYear W28907907612021 @default.
- W2890790761 countsByYear W28907907612022 @default.
- W2890790761 countsByYear W28907907612023 @default.
- W2890790761 crossrefType "journal-article" @default.
- W2890790761 hasAuthorship W2890790761A5012857173 @default.
- W2890790761 hasAuthorship W2890790761A5020848133 @default.
- W2890790761 hasAuthorship W2890790761A5029719511 @default.
- W2890790761 hasAuthorship W2890790761A5043749174 @default.
- W2890790761 hasAuthorship W2890790761A5043850579 @default.
- W2890790761 hasAuthorship W2890790761A5045928207 @default.
- W2890790761 hasAuthorship W2890790761A5051227106 @default.
- W2890790761 hasAuthorship W2890790761A5060033325 @default.
- W2890790761 hasAuthorship W2890790761A5067081413 @default.
- W2890790761 hasAuthorship W2890790761A5078753791 @default.
- W2890790761 hasAuthorship W2890790761A5085332912 @default.
- W2890790761 hasBestOaLocation W28907907611 @default.
- W2890790761 hasConcept C159654299 @default.
- W2890790761 hasConcept C203014093 @default.
- W2890790761 hasConcept C22070199 @default.
- W2890790761 hasConcept C22889606 @default.
- W2890790761 hasConcept C2776090121 @default.
- W2890790761 hasConcept C2778937273 @default.
- W2890790761 hasConcept C2779053233 @default.
- W2890790761 hasConcept C32611913 @default.
- W2890790761 hasConcept C71924100 @default.
- W2890790761 hasConcept C8891405 @default.
- W2890790761 hasConceptScore W2890790761C159654299 @default.