Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890792162> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2890792162 abstract "One of the main and most recent challenges of modern biology is to keep-up with growing amount of biological data coming from next generation sequencing technologies. Keeping up with the growing volumes of experiments will be the only way to make sense of the data and extract actionable biological insights. Large-scale comparative bioinformatics analyses are an integral part of this procedure. When doing comparative bioinformatics, multiple sequence alignments (MSAs) are by far the most widely used models as they provide a unique insight into the accurate measure of sequence similarities and are therefore instrumental to revealing genetic and/or functional relationships among evolutionarily related species. Unfortunately, the well-established limitation of MSA methods when dealing with very large datasets potentially compromises all downstream analysis. In this thesis I expose the current relevance of multiple sequence aligners, I show how their current scaling up is leading to serious numerical stability issues and how they impact phylogenetic tree reconstruction. For this purpose, I have developed two new methods, MEGA-Coffee, a large scale aligner and Shootstrap a novel bootstrapping measure incorporating MSA instability with branch support estimates when computing trees. The large amount of computation required by these two projects was carried using Nextflow, a new computational framework that I have developed to improve computational efficiency and reproducibility of large-scale analyses like the one carried out in the context of these studies." @default.
- W2890792162 created "2018-09-27" @default.
- W2890792162 creator A5086395779 @default.
- W2890792162 date "2016-11-07" @default.
- W2890792162 modified "2023-09-23" @default.
- W2890792162 title "Large-scale comparative bioinformatics analyses" @default.
- W2890792162 hasPublicationYear "2016" @default.
- W2890792162 type Work @default.
- W2890792162 sameAs 2890792162 @default.
- W2890792162 citedByCount "0" @default.
- W2890792162 crossrefType "dissertation" @default.
- W2890792162 hasAuthorship W2890792162A5086395779 @default.
- W2890792162 hasConcept C113174947 @default.
- W2890792162 hasConcept C119857082 @default.
- W2890792162 hasConcept C124101348 @default.
- W2890792162 hasConcept C134306372 @default.
- W2890792162 hasConcept C149782125 @default.
- W2890792162 hasConcept C151730666 @default.
- W2890792162 hasConcept C158154518 @default.
- W2890792162 hasConcept C17744445 @default.
- W2890792162 hasConcept C199539241 @default.
- W2890792162 hasConcept C201797286 @default.
- W2890792162 hasConcept C205649164 @default.
- W2890792162 hasConcept C207609745 @default.
- W2890792162 hasConcept C2522767166 @default.
- W2890792162 hasConcept C2778112365 @default.
- W2890792162 hasConcept C2778755073 @default.
- W2890792162 hasConcept C2779343474 @default.
- W2890792162 hasConcept C33923547 @default.
- W2890792162 hasConcept C41008148 @default.
- W2890792162 hasConcept C54355233 @default.
- W2890792162 hasConcept C58640448 @default.
- W2890792162 hasConcept C60644358 @default.
- W2890792162 hasConcept C86803240 @default.
- W2890792162 hasConceptScore W2890792162C113174947 @default.
- W2890792162 hasConceptScore W2890792162C119857082 @default.
- W2890792162 hasConceptScore W2890792162C124101348 @default.
- W2890792162 hasConceptScore W2890792162C134306372 @default.
- W2890792162 hasConceptScore W2890792162C149782125 @default.
- W2890792162 hasConceptScore W2890792162C151730666 @default.
- W2890792162 hasConceptScore W2890792162C158154518 @default.
- W2890792162 hasConceptScore W2890792162C17744445 @default.
- W2890792162 hasConceptScore W2890792162C199539241 @default.
- W2890792162 hasConceptScore W2890792162C201797286 @default.
- W2890792162 hasConceptScore W2890792162C205649164 @default.
- W2890792162 hasConceptScore W2890792162C207609745 @default.
- W2890792162 hasConceptScore W2890792162C2522767166 @default.
- W2890792162 hasConceptScore W2890792162C2778112365 @default.
- W2890792162 hasConceptScore W2890792162C2778755073 @default.
- W2890792162 hasConceptScore W2890792162C2779343474 @default.
- W2890792162 hasConceptScore W2890792162C33923547 @default.
- W2890792162 hasConceptScore W2890792162C41008148 @default.
- W2890792162 hasConceptScore W2890792162C54355233 @default.
- W2890792162 hasConceptScore W2890792162C58640448 @default.
- W2890792162 hasConceptScore W2890792162C60644358 @default.
- W2890792162 hasConceptScore W2890792162C86803240 @default.
- W2890792162 hasLocation W28907921621 @default.
- W2890792162 hasOpenAccess W2890792162 @default.
- W2890792162 hasPrimaryLocation W28907921621 @default.
- W2890792162 hasRelatedWork W1967843471 @default.
- W2890792162 hasRelatedWork W1986365587 @default.
- W2890792162 hasRelatedWork W1994067454 @default.
- W2890792162 hasRelatedWork W2055855143 @default.
- W2890792162 hasRelatedWork W2056222331 @default.
- W2890792162 hasRelatedWork W2059748942 @default.
- W2890792162 hasRelatedWork W2118435402 @default.
- W2890792162 hasRelatedWork W2123621679 @default.
- W2890792162 hasRelatedWork W2149665870 @default.
- W2890792162 hasRelatedWork W2155301734 @default.
- W2890792162 hasRelatedWork W2471075222 @default.
- W2890792162 hasRelatedWork W2593269377 @default.
- W2890792162 hasRelatedWork W2766147358 @default.
- W2890792162 hasRelatedWork W2768987282 @default.
- W2890792162 hasRelatedWork W2950449245 @default.
- W2890792162 hasRelatedWork W2985786370 @default.
- W2890792162 hasRelatedWork W647950058 @default.
- W2890792162 hasRelatedWork W80582101 @default.
- W2890792162 hasRelatedWork W2186448352 @default.
- W2890792162 hasRelatedWork W2187588232 @default.
- W2890792162 isParatext "false" @default.
- W2890792162 isRetracted "false" @default.
- W2890792162 magId "2890792162" @default.
- W2890792162 workType "dissertation" @default.