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- W2890794370 abstract "Abstract Recent high-throughput-sequencing of cancer genomes has identified oncogenic mutations in the BRaf genetic locus as one of the critical events in melanomagenesis. BRaf encodes a serine/threonine kinase that regulates the MAPK/ERK kinase (MEK) and extracellular signal-regulated kinase (ERK) protein kinase cascade. In normal cells, the activity of BRaf is tightly regulated and is required for cell growth and survival. BRaf gain-of-function mutations in melanoma frequently lead to unrestrained growth, enhanced cell invasion and increased viability of cancer cells. Although it is clear that the invasive phenotypes of BRaf mutated melanoma cells are stringently dependent on BRaf-MEK-ERK activation, the downstream effector targets that are required for oncogenic BRaf-mediated melanomagenesis are not well defined. miRNAs have regulatory functions towards the expression of genes that are important in carcinogenesis. We observed that miR-10b expression correlates with the presence of the oncogenic BRaf ( BRaf V600E ) mutation in melanoma cells. While expression of miR-10b enhances anchorage-independent growth of BRaf wild-type melanoma cells, miR-10b silencing decreases BRaf V600E cancer cell invasion in vitro . Importantly, the expression of miR-10b is required for BRaf V600E -mediated anchorage-independent growth and invasion of melanoma cells in vitro . Taken together our results suggest that miR-10b is an important mediator of oncogenic BRaf V600E activity in melanoma." @default.
- W2890794370 created "2018-09-27" @default.
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- W2890794370 date "2018-09-10" @default.
- W2890794370 modified "2023-09-23" @default.
- W2890794370 title "Critical role of miR-10b in BRafV600E dependent anchorage-independent growth and invasion of melanoma cells" @default.
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- W2890794370 doi "https://doi.org/10.1101/413476" @default.
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