FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890796006> ?p ?o ?g. }

• W2890796006 endingPage "520" @default.
• W2890796006 startingPage "510" @default.
• W2890796006 abstract "Abstract Background: Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative data and secondarily to evaluate the potential utility of GDF-15 in DKD using Roche Diagnostics electrochemiluminescence immunoassay (ECLIA) in an Irish Caucasian population. Methods: Following informed consent, 188 healthy volunteers and 128 participants with diabetes (72 with and 56 without DKD) were recruited to a cross-sectional study. Baseline demographics, anthropometric measurements and laboratory measurements were recorded. Blood for GDF-15 measurement was collected into plain specimen tubes kept at room temperature and processed (centrifugation, separation of serum, freezing at −80 °C) within 1 h of phlebotomy pending batch analyses. Reference intervals were determined using the 2.5th and 97.5th percentiles for serum GDF-15 concentration. Results: Of 188 healthy participants, 63 failed to meet study inclusion criteria. The reference interval for serum GDF-15 was 399 ng/L (90% confidence interval [CI]: 399–399) – 1335 ng/L (90% CI: 1152–1445). Receiver operator characteristics (ROC) curve analysis for DKD determined the area under the ROC curve to be 0.931 (95% CI: 0.893–0.959; p<0.001). The optimum GDF-15 cutoff for predicting DKD was >1136 ng/L providing a diagnostic sensitivity and specificity of 94.4% and 79%, respectively, and positive likelihood ratio of 4.5:1 (95% CI: 3.4–6.0). Conclusions: The reference interval for serum GDF-15 in a healthy Irish Caucasian population using Roche Diagnostics ECLIA was established and a preliminary determination of the potential of GDF-15 as a screening test for DKD was made. Further prospective validation with a larger DKD cohort will be required before the cutoff presented here is recommended for clinical use." @default.
• W2890796006 created "2018-09-27" @default.
• W2890796006 creator A5010089797 @default.
• W2890796006 creator A5027342565 @default.
• W2890796006 creator A5030092370 @default.
• W2890796006 creator A5039597943 @default.
• W2890796006 creator A5051832240 @default.
• W2890796006 creator A5076961908 @default.
• W2890796006 date "2018-09-15" @default.
• W2890796006 modified "2023-10-16" @default.
• W2890796006 title "Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD)" @default.
• W2890796006 cites W1507364611 @default.
• W2890796006 cites W1930145556 @default.
• W2890796006 cites W1972121894 @default.
• W2890796006 cites W1995550877 @default.
• W2890796006 cites W1996141009 @default.
• W2890796006 cites W2001933911 @default.
• W2890796006 cites W2022651915 @default.
• W2890796006 cites W2043575472 @default.
• W2890796006 cites W2047613631 @default.
• W2890796006 cites W2051693610 @default.
• W2890796006 cites W2058302382 @default.
• W2890796006 cites W2065858724 @default.
• W2890796006 cites W2068138485 @default.
• W2890796006 cites W2093935755 @default.
• W2890796006 cites W2094649259 @default.
• W2890796006 cites W2115162399 @default.
• W2890796006 cites W2125076515 @default.
• W2890796006 cites W2131137978 @default.
• W2890796006 cites W2135954766 @default.
• W2890796006 cites W2137876795 @default.
• W2890796006 cites W2147549360 @default.
• W2890796006 cites W2155965977 @default.
• W2890796006 cites W2164388248 @default.
• W2890796006 cites W2299022451 @default.
• W2890796006 cites W2303642638 @default.
• W2890796006 cites W2328056838 @default.
• W2890796006 cites W2409903382 @default.
• W2890796006 cites W2534685426 @default.
• W2890796006 cites W2545266774 @default.
• W2890796006 cites W2550312612 @default.
• W2890796006 cites W2585734598 @default.
• W2890796006 cites W2589119404 @default.
• W2890796006 cites W2599011697 @default.
• W2890796006 cites W2751312379 @default.
• W2890796006 cites W2799677404 @default.
• W2890796006 cites W2802705176 @default.
• W2890796006 cites W3021250193 @default.
• W2890796006 doi "https://doi.org/10.1515/cclm-2018-0534" @default.
• W2890796006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218600" @default.
• W2890796006 hasPublicationYear "2018" @default.
• W2890796006 type Work @default.
• W2890796006 sameAs 2890796006 @default.
• W2890796006 citedByCount "19" @default.
• W2890796006 countsByYear W28907960062019 @default.
• W2890796006 countsByYear W28907960062020 @default.
• W2890796006 countsByYear W28907960062021 @default.
• W2890796006 countsByYear W28907960062022 @default.
• W2890796006 countsByYear W28907960062023 @default.
• W2890796006 crossrefType "journal-article" @default.
• W2890796006 hasAuthorship W2890796006A5010089797 @default.
• W2890796006 hasAuthorship W2890796006A5027342565 @default.
• W2890796006 hasAuthorship W2890796006A5030092370 @default.
• W2890796006 hasAuthorship W2890796006A5039597943 @default.
• W2890796006 hasAuthorship W2890796006A5051832240 @default.
• W2890796006 hasAuthorship W2890796006A5076961908 @default.
• W2890796006 hasBestOaLocation W28907960062 @default.
• W2890796006 hasConcept C126322002 @default.
• W2890796006 hasConcept C126894567 @default.
• W2890796006 hasConcept C136935669 @default.
• W2890796006 hasConcept C185592680 @default.
• W2890796006 hasConcept C2781197716 @default.
• W2890796006 hasConcept C2908647359 @default.
• W2890796006 hasConcept C44249647 @default.
• W2890796006 hasConcept C55493867 @default.
• W2890796006 hasConcept C58471807 @default.
• W2890796006 hasConcept C71924100 @default.
• W2890796006 hasConcept C90924648 @default.
• W2890796006 hasConcept C99454951 @default.
• W2890796006 hasConceptScore W2890796006C126322002 @default.
• W2890796006 hasConceptScore W2890796006C126894567 @default.
• W2890796006 hasConceptScore W2890796006C136935669 @default.
• W2890796006 hasConceptScore W2890796006C185592680 @default.
• W2890796006 hasConceptScore W2890796006C2781197716 @default.
• W2890796006 hasConceptScore W2890796006C2908647359 @default.
• W2890796006 hasConceptScore W2890796006C44249647 @default.
• W2890796006 hasConceptScore W2890796006C55493867 @default.
• W2890796006 hasConceptScore W2890796006C58471807 @default.
• W2890796006 hasConceptScore W2890796006C71924100 @default.
• W2890796006 hasConceptScore W2890796006C90924648 @default.
• W2890796006 hasConceptScore W2890796006C99454951 @default.
• W2890796006 hasIssue "4" @default.
• W2890796006 hasLocation W28907960061 @default.
• W2890796006 hasLocation W28907960062 @default.
• W2890796006 hasOpenAccess W2890796006 @default.
• W2890796006 hasPrimaryLocation W28907960061 @default.
• W2890796006 hasRelatedWork W1452345948 @default.
• W2890796006 hasRelatedWork W1989666771 @default.

• next