Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890796174> ?p ?o ?g. }
- W2890796174 abstract "Due to the high transfer ability of cancer cell, cancer has been regarded as a world-wide high mortality disease. Quantitative analysis of circulating tumor cells (CTCs) can provide some valuable clinical information that is particularly critical for cancer diagnosis and treatment. Along with the rapid development of micro-/nano-fabrication technique, the three-dimensional (3D) bionic interface-based analysis method has become a hot research topic in the area of nanotechnology and life science. Micro-/nano-structure-based devices have been identified as being one of the easiest and most effective techniques for CTCs capture applications.We demonstrated an electrospun nanofibers-deposited nickel (Ni) micropillars-based cytosensor for electrochemical detection of CTCs. Breast cancer cell line with rich EpCAM expression (MCF7) were selected as model CTCs. The ultra-long poly (lactic-co-glycolic acid) (PLGA) nanofibers were firstly-crosswise stacked onto the surface of Ni micropillars by electrospinning to construct a 3D bionic interface for capturing EpCAM-expressing CTCs, following immuno-recognition with quantum dots functionalized anti-EpCAM antibody (QDs-Ab) and forming immunocomplexes on the micro-/nano-chip.The Ni micropillars in the longitudinal direction not only play a certain electrical conductivity in the electrochemical detection, but also its special structure improves the efficiency of cell capture. The cross-aligned nanofibers could simulate the extracellular matrix to provide a good microenvironment which is better for cell adhesion and physiological functions. Bioprobe containing quantum dots will release Cd2+ in the process of acid dissolution, resulting in a change in current. Beneath favourable conditions, the suggested 3D cytosensor demonstrated high sensitivity with a broad range of 101-105 cells mL-1 and a detection limit of 8 cells mL-1.We constructed a novel 3D electrochemical cytosensor based on Ni micropillars, PLGA electrospun nanofibers and quantum dots bioprobe, which could be used to highly sensitive and selective analysis of CTCs. More significantly, the 3D cytosensor can efficiently identify CTCs from whole blood, which suggested the potential applications of our technique for the clinical diagnosis and therapeutic monitoring of cancers." @default.
- W2890796174 created "2018-09-27" @default.
- W2890796174 creator A5023633722 @default.
- W2890796174 creator A5025298905 @default.
- W2890796174 creator A5041798036 @default.
- W2890796174 creator A5060905856 @default.
- W2890796174 creator A5073976176 @default.
- W2890796174 creator A5081805949 @default.
- W2890796174 creator A5085462851 @default.
- W2890796174 creator A5089948112 @default.
- W2890796174 date "2018-09-11" @default.
- W2890796174 modified "2023-10-13" @default.
- W2890796174 title "A micro-/nano-chip and quantum dots-based 3D cytosensor for quantitative analysis of circulating tumor cells" @default.
- W2890796174 cites W1938655770 @default.
- W2890796174 cites W1963535189 @default.
- W2890796174 cites W1970655967 @default.
- W2890796174 cites W1982760718 @default.
- W2890796174 cites W1989307187 @default.
- W2890796174 cites W1994379261 @default.
- W2890796174 cites W2026948909 @default.
- W2890796174 cites W2043464552 @default.
- W2890796174 cites W2051572649 @default.
- W2890796174 cites W2057992135 @default.
- W2890796174 cites W2059747751 @default.
- W2890796174 cites W2078577466 @default.
- W2890796174 cites W2098085342 @default.
- W2890796174 cites W2109826944 @default.
- W2890796174 cites W2121042530 @default.
- W2890796174 cites W2124160990 @default.
- W2890796174 cites W2159548096 @default.
- W2890796174 cites W2207498669 @default.
- W2890796174 cites W2279554141 @default.
- W2890796174 cites W2302292928 @default.
- W2890796174 cites W2314379510 @default.
- W2890796174 cites W2332472323 @default.
- W2890796174 cites W2464840667 @default.
- W2890796174 cites W2509043347 @default.
- W2890796174 cites W2551245464 @default.
- W2890796174 cites W2594913108 @default.
- W2890796174 cites W2605972655 @default.
- W2890796174 cites W2749602354 @default.
- W2890796174 cites W2783794287 @default.
- W2890796174 cites W2789585536 @default.
- W2890796174 cites W2793380396 @default.
- W2890796174 doi "https://doi.org/10.1186/s12951-018-0390-x" @default.
- W2890796174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131777" @default.
- W2890796174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30205821" @default.
- W2890796174 hasPublicationYear "2018" @default.
- W2890796174 type Work @default.
- W2890796174 sameAs 2890796174 @default.
- W2890796174 citedByCount "30" @default.
- W2890796174 countsByYear W28907961742018 @default.
- W2890796174 countsByYear W28907961742019 @default.
- W2890796174 countsByYear W28907961742020 @default.
- W2890796174 countsByYear W28907961742021 @default.
- W2890796174 countsByYear W28907961742022 @default.
- W2890796174 countsByYear W28907961742023 @default.
- W2890796174 crossrefType "journal-article" @default.
- W2890796174 hasAuthorship W2890796174A5023633722 @default.
- W2890796174 hasAuthorship W2890796174A5025298905 @default.
- W2890796174 hasAuthorship W2890796174A5041798036 @default.
- W2890796174 hasAuthorship W2890796174A5060905856 @default.
- W2890796174 hasAuthorship W2890796174A5073976176 @default.
- W2890796174 hasAuthorship W2890796174A5081805949 @default.
- W2890796174 hasAuthorship W2890796174A5085462851 @default.
- W2890796174 hasAuthorship W2890796174A5089948112 @default.
- W2890796174 hasBestOaLocation W28907961741 @default.
- W2890796174 hasConcept C121608353 @default.
- W2890796174 hasConcept C124657808 @default.
- W2890796174 hasConcept C126322002 @default.
- W2890796174 hasConcept C144796933 @default.
- W2890796174 hasConcept C159985019 @default.
- W2890796174 hasConcept C171250308 @default.
- W2890796174 hasConcept C185592680 @default.
- W2890796174 hasConcept C192562407 @default.
- W2890796174 hasConcept C2779013556 @default.
- W2890796174 hasConcept C2780357685 @default.
- W2890796174 hasConcept C521977710 @default.
- W2890796174 hasConcept C61238886 @default.
- W2890796174 hasConcept C71924100 @default.
- W2890796174 hasConcept C91129048 @default.
- W2890796174 hasConcept C96232424 @default.
- W2890796174 hasConceptScore W2890796174C121608353 @default.
- W2890796174 hasConceptScore W2890796174C124657808 @default.
- W2890796174 hasConceptScore W2890796174C126322002 @default.
- W2890796174 hasConceptScore W2890796174C144796933 @default.
- W2890796174 hasConceptScore W2890796174C159985019 @default.
- W2890796174 hasConceptScore W2890796174C171250308 @default.
- W2890796174 hasConceptScore W2890796174C185592680 @default.
- W2890796174 hasConceptScore W2890796174C192562407 @default.
- W2890796174 hasConceptScore W2890796174C2779013556 @default.
- W2890796174 hasConceptScore W2890796174C2780357685 @default.
- W2890796174 hasConceptScore W2890796174C521977710 @default.
- W2890796174 hasConceptScore W2890796174C61238886 @default.
- W2890796174 hasConceptScore W2890796174C71924100 @default.
- W2890796174 hasConceptScore W2890796174C91129048 @default.
- W2890796174 hasConceptScore W2890796174C96232424 @default.
- W2890796174 hasFunder F4320321001 @default.
- W2890796174 hasIssue "1" @default.
- W2890796174 hasLocation W28907961741 @default.