Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890796811> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2890796811 abstract "Various models for an experimental study of gastric ulcers and erosions were sought and high incidences of erosion or ulceration were obtained using stress (Restraint), antiinflammatory drugs (phenylbutazone, aspirin), a corticosteroid (prednisolone) and physical or chemical trauma (electrocautery or acetic acid). Reproducible results were obtained only by carefully controlling variables such as sex, bodyweight, temperature and season. Histochemically,erosions and ulcers were associated with a loss of mucus, particularly from the regenerative zone of the mucosa. Biochemical studies after erosion formation confirmed the decrease in mucus content and also showed an altered carbohydrate composition of the mucus. Studies of mucous glycoprotein synthesis by measuring the rate of incorporation of labelled carbohydrate and amino acid suggested that one mode of action of stress and ulcerogenic drugs may be inhibition of the glycosylation of the mucus glycoprotein and hence a decreased synthesis of glycoprotein or the synthesis of a modified glycoprotein or both. Prostaglandins E[1], E[2] and F[2] were found to decrease the incorporation of carbohydrate and amino acid. This effect may be produced by stimulation of adenyl cyclase and elevation of cyclic AMP levels as the dibutyryl analogue of cyclic AMP and a phosphodiesterase inhibitor, theophylline were found to have similar effects. The dibutyryl analogue of cyclic GMP was found to have no effect on glycoprotein synthesis. Glycaemia was also found to be important as hypoglycaemia decreased glycoprotein synthesis and increased the susceptibility to erosion formation. It appears that a constant supply of glucose to the mucosal cells is necessary for synthesis of the mucus glycoprotein and normal cell function. The drug carbenoxolone sodium and an analogue cicloxolone sodium were shown to be effective against stress-induced erosions and also promoted the healing of electrocautery ulcers. The mechanism of action may be allied with increased mucus synthesis as both drugs were shown to increase the glycosylation of mucus glycoproteins." @default.
- W2890796811 created "2018-09-27" @default.
- W2890796811 creator A5071586542 @default.
- W2890796811 date "1976-01-01" @default.
- W2890796811 modified "2023-09-23" @default.
- W2890796811 title "A study of experimental gastric ulcers and erosions." @default.
- W2890796811 hasPublicationYear "1976" @default.
- W2890796811 type Work @default.
- W2890796811 sameAs 2890796811 @default.
- W2890796811 citedByCount "0" @default.
- W2890796811 crossrefType "dissertation" @default.
- W2890796811 hasAuthorship W2890796811A5071586542 @default.
- W2890796811 hasConcept C108625454 @default.
- W2890796811 hasConcept C126322002 @default.
- W2890796811 hasConcept C134018914 @default.
- W2890796811 hasConcept C185592680 @default.
- W2890796811 hasConcept C18903297 @default.
- W2890796811 hasConcept C24998067 @default.
- W2890796811 hasConcept C2776766087 @default.
- W2890796811 hasConcept C2777312293 @default.
- W2890796811 hasConcept C2778095195 @default.
- W2890796811 hasConcept C2778977261 @default.
- W2890796811 hasConcept C55493867 @default.
- W2890796811 hasConcept C71924100 @default.
- W2890796811 hasConcept C86803240 @default.
- W2890796811 hasConcept C98274493 @default.
- W2890796811 hasConceptScore W2890796811C108625454 @default.
- W2890796811 hasConceptScore W2890796811C126322002 @default.
- W2890796811 hasConceptScore W2890796811C134018914 @default.
- W2890796811 hasConceptScore W2890796811C185592680 @default.
- W2890796811 hasConceptScore W2890796811C18903297 @default.
- W2890796811 hasConceptScore W2890796811C24998067 @default.
- W2890796811 hasConceptScore W2890796811C2776766087 @default.
- W2890796811 hasConceptScore W2890796811C2777312293 @default.
- W2890796811 hasConceptScore W2890796811C2778095195 @default.
- W2890796811 hasConceptScore W2890796811C2778977261 @default.
- W2890796811 hasConceptScore W2890796811C55493867 @default.
- W2890796811 hasConceptScore W2890796811C71924100 @default.
- W2890796811 hasConceptScore W2890796811C86803240 @default.
- W2890796811 hasConceptScore W2890796811C98274493 @default.
- W2890796811 hasLocation W28907968111 @default.
- W2890796811 hasOpenAccess W2890796811 @default.
- W2890796811 hasPrimaryLocation W28907968111 @default.
- W2890796811 hasRelatedWork W105904928 @default.
- W2890796811 hasRelatedWork W1742623647 @default.
- W2890796811 hasRelatedWork W1976592336 @default.
- W2890796811 hasRelatedWork W1985896309 @default.
- W2890796811 hasRelatedWork W1997567694 @default.
- W2890796811 hasRelatedWork W2011682680 @default.
- W2890796811 hasRelatedWork W2044480774 @default.
- W2890796811 hasRelatedWork W2051650058 @default.
- W2890796811 hasRelatedWork W2054229509 @default.
- W2890796811 hasRelatedWork W2060203276 @default.
- W2890796811 hasRelatedWork W2066190097 @default.
- W2890796811 hasRelatedWork W2090746672 @default.
- W2890796811 hasRelatedWork W2110771268 @default.
- W2890796811 hasRelatedWork W2340883559 @default.
- W2890796811 hasRelatedWork W2396656824 @default.
- W2890796811 hasRelatedWork W2412924793 @default.
- W2890796811 hasRelatedWork W2435410974 @default.
- W2890796811 hasRelatedWork W2443600911 @default.
- W2890796811 hasRelatedWork W1497599560 @default.
- W2890796811 hasRelatedWork W98209861 @default.
- W2890796811 isParatext "false" @default.
- W2890796811 isRetracted "false" @default.
- W2890796811 magId "2890796811" @default.
- W2890796811 workType "dissertation" @default.