FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890797776> ?p ?o ?g. }

• W2890797776 endingPage "2298" @default.
• W2890797776 startingPage "2285" @default.
• W2890797776 abstract "Background: Systemic lupus erythematous (SLE) is an autoimmune disease characterized by the production of autoantibodies directed against various autoantigens. But the expression profiles and functions of circular RNAs (circRNAs) in SLE are still scarce. Objectives: To explore the roles of circRNA in SLE and its potential diagnostic potential in SLE. Methods: SLE patients and healthy control subjects were recruited. CD4+ T cells were isolated, circRNA microarray analysis were used to screen for circRNA candidate in CD4+ T cells. Expression of DNMT1, CD11a and CD70, and methylation level of CD11a and CD70 were detected after transfecting hsa_circ_0012919-targetted siRNA. The network analysis of hsa_circ_0012919 was used by bioinformatics. Luciferase reporter assay and fluorescence in situ hybridization (FISH) assay were used for screening for which miRNAs could bind with hsa_circ_0012919. Results: Twelve circRNAs were up-regulated and two circRNAs were down-regulated in SLE patients group after circRNA microarray analysis. Hsa_circ_0012919 was further confirmed to be significantly different between healthy control and SLE patients (P&lt;0.05) and associated with SLE characters (P&lt;0.05). Down-regulation of hsa_circ_0012919 (i) increased the expression of DNMT1 and reduced the expression of CD70, CD11a, (ii) reversed the DNA hypomethylation of CD11a and CD70 in CD4+ T cells of SLE, but it could be reversed by down-regulation of DNMT1. Hsa_circ_0012919 regulated KLF13 and RANTES by miR-125a. Conclusion: Hsa_circ_0012919 could be regarded as a biomarker for SLE and hsa_circ_0012919 was the competitive endogenous RNA (ceRNA) for miR-125a-3p." @default.
• W2890797776 created "2018-09-27" @default.
• W2890797776 creator A5001281974 @default.
• W2890797776 creator A5006822602 @default.
• W2890797776 creator A5029705815 @default.
• W2890797776 creator A5034328554 @default.
• W2890797776 creator A5085918263 @default.
• W2890797776 creator A5089966579 @default.
• W2890797776 date "2018-11-02" @default.
• W2890797776 modified "2023-09-30" @default.
• W2890797776 title "The down-regulation of hsa_circ_0012919, the sponge for <i>miR-125a-3p</i>, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous" @default.
• W2890797776 cites W1971073907 @default.
• W2890797776 cites W1976100146 @default.
• W2890797776 cites W1988496769 @default.
• W2890797776 cites W2014912378 @default.
• W2890797776 cites W2024073989 @default.
• W2890797776 cites W2048396024 @default.
• W2890797776 cites W2110962567 @default.
• W2890797776 cites W2120040672 @default.
• W2890797776 cites W2124786596 @default.
• W2890797776 cites W2167646298 @default.
• W2890797776 cites W2426975785 @default.
• W2890797776 cites W2510327939 @default.
• W2890797776 cites W2523252243 @default.
• W2890797776 cites W2545664059 @default.
• W2890797776 cites W2585445010 @default.
• W2890797776 cites W2594477541 @default.
• W2890797776 cites W2596298550 @default.
• W2890797776 cites W2613179596 @default.
• W2890797776 cites W2616072553 @default.
• W2890797776 cites W2623552909 @default.
• W2890797776 cites W2626382155 @default.
• W2890797776 cites W2740070725 @default.
• W2890797776 cites W2741786914 @default.
• W2890797776 cites W2800008025 @default.
• W2890797776 cites W2801590497 @default.
• W2890797776 doi "https://doi.org/10.1042/cs20180403" @default.
• W2890797776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30237316" @default.
• W2890797776 hasPublicationYear "2018" @default.
• W2890797776 type Work @default.
• W2890797776 sameAs 2890797776 @default.
• W2890797776 citedByCount "53" @default.
• W2890797776 countsByYear W28907977762019 @default.
• W2890797776 countsByYear W28907977762020 @default.
• W2890797776 countsByYear W28907977762021 @default.
• W2890797776 countsByYear W28907977762022 @default.
• W2890797776 countsByYear W28907977762023 @default.
• W2890797776 crossrefType "journal-article" @default.
• W2890797776 hasAuthorship W2890797776A5001281974 @default.
• W2890797776 hasAuthorship W2890797776A5006822602 @default.
• W2890797776 hasAuthorship W2890797776A5029705815 @default.
• W2890797776 hasAuthorship W2890797776A5034328554 @default.
• W2890797776 hasAuthorship W2890797776A5085918263 @default.
• W2890797776 hasAuthorship W2890797776A5089966579 @default.
• W2890797776 hasConcept C104317684 @default.
• W2890797776 hasConcept C145059251 @default.
• W2890797776 hasConcept C150194340 @default.
• W2890797776 hasConcept C153911025 @default.
• W2890797776 hasConcept C159654299 @default.
• W2890797776 hasConcept C163764329 @default.
• W2890797776 hasConcept C175211621 @default.
• W2890797776 hasConcept C185592680 @default.
• W2890797776 hasConcept C186836561 @default.
• W2890797776 hasConcept C190727270 @default.
• W2890797776 hasConcept C203014093 @default.
• W2890797776 hasConcept C2781197716 @default.
• W2890797776 hasConcept C33288867 @default.
• W2890797776 hasConcept C502942594 @default.
• W2890797776 hasConcept C54355233 @default.
• W2890797776 hasConcept C86803240 @default.
• W2890797776 hasConceptScore W2890797776C104317684 @default.
• W2890797776 hasConceptScore W2890797776C145059251 @default.
• W2890797776 hasConceptScore W2890797776C150194340 @default.
• W2890797776 hasConceptScore W2890797776C153911025 @default.
• W2890797776 hasConceptScore W2890797776C159654299 @default.
• W2890797776 hasConceptScore W2890797776C163764329 @default.
• W2890797776 hasConceptScore W2890797776C175211621 @default.
• W2890797776 hasConceptScore W2890797776C185592680 @default.
• W2890797776 hasConceptScore W2890797776C186836561 @default.
• W2890797776 hasConceptScore W2890797776C190727270 @default.
• W2890797776 hasConceptScore W2890797776C203014093 @default.
• W2890797776 hasConceptScore W2890797776C2781197716 @default.
• W2890797776 hasConceptScore W2890797776C33288867 @default.
• W2890797776 hasConceptScore W2890797776C502942594 @default.
• W2890797776 hasConceptScore W2890797776C54355233 @default.
• W2890797776 hasConceptScore W2890797776C86803240 @default.
• W2890797776 hasIssue "21" @default.
• W2890797776 hasLocation W28907977761 @default.
• W2890797776 hasLocation W28907977762 @default.
• W2890797776 hasOpenAccess W2890797776 @default.
• W2890797776 hasPrimaryLocation W28907977761 @default.
• W2890797776 hasRelatedWork W1002145718 @default.
• W2890797776 hasRelatedWork W1534737270 @default.
• W2890797776 hasRelatedWork W1677176897 @default.
• W2890797776 hasRelatedWork W1981350331 @default.
• W2890797776 hasRelatedWork W1999240025 @default.
• W2890797776 hasRelatedWork W2065044476 @default.
• W2890797776 hasRelatedWork W2237730446 @default.

• next