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• W2890798717 abstract "Abstract Introduction Tumor metastasis is the most important biological property of malignant tumors, and it can lead to poor prognosis. Studies have shown that transforming growth factor-β (TGF-β)/Smad signaling pathway acts an extremely important part in the process of tumor metastasis. Hedyotis diffusa Willd (HDW) is an effective anti-cancer medicine, which is accomplished in treating various types of cancer, including colorectal cancer (CRC). Nevertheless, the mechanism by which HDW inhibits metastasis of CRC is unclear. Therefore, to further clarify the molecular mechanism of its anti-CRC, we studied the effects of ethanol extract of HDW (EEHDW) on CRC cell metastasis through inhibition of TGF-β-induced EMT. Methods TGF-β stimulated CRC cell line HCT-8 cells were used, together with MTT and Transwell assays in order to assess the effect of EEHDW on the proliferation, migration and invasion of HCT-8 cells. Furthermore, the expression of markers of EMT (E-cadherin, N-cadherin, Vimentin) and TGF-β signaling pathway associated protein were detected by western blot. Results TGF-β could promote cell proliferation, moreover, TGF-β could increase the migration and invasion ability of HCT-8 cells markedly, and TGF-β induced EMT by up-regulating the expression of N-cadherin and Vimentin, down-regulating the expression of E-cadherin. The expression of related proteins (TGF-β, p-Smad2/3, Smad4) in the TGF-β/Smad pathway was increased by TGF-β. After treating with EEHDW, we observed that cell viability was reduced by EEHDW markly, inhibited the proliferation of HCT-8 cells, moreover, it could attenuate the transfer capacity of HCT-8 cells in a dose-dependent manner. Furthermore, EEHDW decreased the expression of N-cadherin, Vimentin and the proteins (TGF-β, p-Smad2/3, Smad4) in TGF-β signaling pathway, but increased the expression of E-cadherin. Conclusion EEHDW reduces migration and invasion through inhibition of TGF-β-induced EMT in colorectal cancer cells." @default.
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• W2890798717 date "2018-10-01" @default.
• W2890798717 modified "2023-10-16" @default.
• W2890798717 title "Hedyotis diffusa Willd reduces migration and invasion through inhibition of TGF-β-induced EMT in colorectal cancer cells" @default.
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• W2890798717 doi "https://doi.org/10.1016/j.eujim.2018.09.008" @default.
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