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- W2890804940 abstract "Nuclear speckles (NSs) serve as splicing factor storage sites. In this study, we unexpectedly found that many endogenous intronless mRNAs, which do not undergo splicing, associate with NSs. These associations do not require transcription, polyadenylation, or the polyA tail. Rather, exonic splicing enhancers present in intronless mRNAs and their binding partners, SR proteins, promote intronless mRNA localization to NSs. Significantly, speckle targeting of mRNAs promotes the recruitment of the TREX export complex and their TREX-dependent nuclear export. Furthermore, TREX, which accumulates in NSs, is required for releasing intronless mRNAs from NSs, whereas NXF1, which is mainly detected at nuclear pores, is not. Upon NXF1 depletion, the TREX protein UAP56 loses speckle concentration but coaccumulates with intronless mRNAs and polyA RNAs in the nucleoplasm, and these RNAs are trapped in NSs upon UAP56 codepletion. We propose that the export-competent messenger RNP assembly mainly occurs in NSs for intronless mRNAs and that entering NSs serves as a quality control step in mRNA export." @default.
- W2890804940 created "2018-09-27" @default.
- W2890804940 creator A5016122096 @default.
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- W2890804940 date "2018-09-07" @default.
- W2890804940 modified "2023-10-15" @default.
- W2890804940 title "Intronless mRNAs transit through nuclear speckles to gain export competence" @default.
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- W2890804940 doi "https://doi.org/10.1083/jcb.201801184" @default.
- W2890804940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6219727" @default.
- W2890804940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30194269" @default.
- W2890804940 hasPublicationYear "2018" @default.
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