FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890806874> ?p ?o ?g. }

• W2890806874 endingPage "e12524" @default.
• W2890806874 startingPage "e12524" @default.
• W2890806874 abstract "Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota." @default.
• W2890806874 created "2018-09-27" @default.
• W2890806874 creator A5004917251 @default.
• W2890806874 creator A5008929986 @default.
• W2890806874 creator A5020782382 @default.
• W2890806874 creator A5025275209 @default.
• W2890806874 creator A5025749021 @default.
• W2890806874 creator A5030446424 @default.
• W2890806874 creator A5032538237 @default.
• W2890806874 creator A5037092559 @default.
• W2890806874 creator A5050563694 @default.
• W2890806874 creator A5051571900 @default.
• W2890806874 creator A5052223213 @default.
• W2890806874 creator A5056778458 @default.
• W2890806874 creator A5058637832 @default.
• W2890806874 creator A5063159500 @default.
• W2890806874 creator A5068801234 @default.
• W2890806874 creator A5080769544 @default.
• W2890806874 creator A5086114240 @default.
• W2890806874 creator A5090845983 @default.
• W2890806874 date "2018-10-12" @default.
• W2890806874 modified "2023-10-18" @default.
• W2890806874 title "Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high-fat diet-fed mice" @default.
• W2890806874 cites W1571607434 @default.
• W2890806874 cites W1793035576 @default.
• W2890806874 cites W1894114341 @default.
• W2890806874 cites W1928460949 @default.
• W2890806874 cites W1965785723 @default.
• W2890806874 cites W1975549936 @default.
• W2890806874 cites W1986142882 @default.
• W2890806874 cites W1986715541 @default.
• W2890806874 cites W1987636018 @default.
• W2890806874 cites W1996175687 @default.
• W2890806874 cites W2005801109 @default.
• W2890806874 cites W2007879814 @default.
• W2890806874 cites W2021325008 @default.
• W2890806874 cites W2031661979 @default.
• W2890806874 cites W2036673125 @default.
• W2890806874 cites W2037319735 @default.
• W2890806874 cites W2037648723 @default.
• W2890806874 cites W2044482540 @default.
• W2890806874 cites W2050845656 @default.
• W2890806874 cites W2057039181 @default.
• W2890806874 cites W2057632593 @default.
• W2890806874 cites W2067251091 @default.
• W2890806874 cites W2068661217 @default.
• W2890806874 cites W2079077642 @default.
• W2890806874 cites W2080627209 @default.
• W2890806874 cites W2100741632 @default.
• W2890806874 cites W2110300022 @default.
• W2890806874 cites W2125784987 @default.
• W2890806874 cites W2129737763 @default.
• W2890806874 cites W2132033020 @default.
• W2890806874 cites W2138418546 @default.
• W2890806874 cites W2161332823 @default.
• W2890806874 cites W2165067288 @default.
• W2890806874 cites W2165400692 @default.
• W2890806874 cites W2167628711 @default.
• W2890806874 cites W2171016495 @default.
• W2890806874 cites W2189933127 @default.
• W2890806874 cites W2233291722 @default.
• W2890806874 cites W2238743437 @default.
• W2890806874 cites W2295225758 @default.
• W2890806874 cites W2303446781 @default.
• W2890806874 cites W2409656339 @default.
• W2890806874 cites W2553615018 @default.
• W2890806874 cites W2557766453 @default.
• W2890806874 cites W2558015986 @default.
• W2890806874 cites W2560147436 @default.
• W2890806874 cites W2561920597 @default.
• W2890806874 cites W2575800736 @default.
• W2890806874 cites W2584483284 @default.
• W2890806874 cites W2584810578 @default.
• W2890806874 cites W2585087950 @default.
• W2890806874 cites W2587996254 @default.
• W2890806874 cites W2605401907 @default.
• W2890806874 cites W2607432572 @default.
• W2890806874 cites W2616430524 @default.
• W2890806874 cites W2733312511 @default.
• W2890806874 cites W2752251608 @default.
• W2890806874 cites W2754392973 @default.
• W2890806874 cites W2761079621 @default.
• W2890806874 cites W2773017482 @default.
• W2890806874 cites W2774551015 @default.
• W2890806874 cites W2795138078 @default.
• W2890806874 cites W2802421303 @default.
• W2890806874 cites W4253137490 @default.
• W2890806874 doi "https://doi.org/10.1111/jpi.12524" @default.
• W2890806874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30230594" @default.
• W2890806874 hasPublicationYear "2018" @default.
• W2890806874 type Work @default.
• W2890806874 sameAs 2890806874 @default.
• W2890806874 citedByCount "255" @default.
• W2890806874 countsByYear W28908068742018 @default.
• W2890806874 countsByYear W28908068742019 @default.
• W2890806874 countsByYear W28908068742020 @default.
• W2890806874 countsByYear W28908068742021 @default.
• W2890806874 countsByYear W28908068742022 @default.

• next