FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890807124> ?p ?o ?g. }

• W2890807124 endingPage "195001" @default.
• W2890807124 startingPage "195001" @default.
• W2890807124 abstract "Currently, the relative biological effectiveness (RBE) is assumed to be constant with a value of 1.1 in proton therapy. Although trends of RBE variations are well known, absolute values in patients are associated with considerable uncertainties. This study aims to evaluate the impact of a variable proton RBE in proton therapy liver trials using different fractionation schemes. Sixteen liver cancer cases were evaluated assuming two clinical schedules of 40 Gy/5 fractions and 58.05 Gy/15 fractions. The linear energy transfer (LET) and physical dose distribution in patients were simulated using Monte Carlo. The variable RBE distribution was calculated using a phenomenological model, considering the influence of the LET, fraction size and α/β value. Further, models to predict normal tissue complication probability (NTCP) and tumor control probability (TCP) were used to investigate potential RBE effects on outcome predictions. Applying the variable RBE model to the 5 and 15 fractions schedules results in an increase in mean fraction-size equivalent dose (FED) to the normal liver of 5.0% and 9.6% respectively. For patients with a mean FED to the normal liver larger than 29.8 Gy, this results in a non-negligible increase in the predicted NTCP of the normal liver averaging 11.6%, ranging from 2.7% to 25.6%. On the other hand, decrease in TCP was less than 5% for both fractionation regimens for all patients when assuming a variable RBE instead of constant. Consequently, the difference in TCP between the two fractionation schedules did not change significantly assuming a variable RBE while the impact on the NTCP difference was highly case specific. In addition, both the NTCP and TCP decrease with increasing α/β value for both fractionation schemes, with the decreases being more pronounced when using a variable RBE compared to using RBE = 1.1. Assuming a constant RBE of 1.1 most likely overestimates the therapeutic ratio in proton therapy for liver cancer, predominantly due to underestimation of the RBE-weighted dose to the normal liver. The impact of applying a variable RBE (as compared to RBE = 1.1) on the NTCP difference of the two fractionation regimens is case dependent. A variable RBE results in a slight increase in TCP difference. Variations in patient radiosensitivity increase when using a variable RBE." @default.
• W2890807124 created "2018-09-27" @default.
• W2890807124 creator A5005317598 @default.
• W2890807124 creator A5023459910 @default.
• W2890807124 creator A5037938903 @default.
• W2890807124 creator A5044225007 @default.
• W2890807124 creator A5072499473 @default.
• W2890807124 date "2018-09-21" @default.
• W2890807124 modified "2023-09-29" @default.
• W2890807124 title "Impact of potentially variable RBE in liver proton therapy" @default.
• W2890807124 cites W1964652457 @default.
• W2890807124 cites W1976552930 @default.
• W2890807124 cites W1996278026 @default.
• W2890807124 cites W2000593531 @default.
• W2890807124 cites W2002022267 @default.
• W2890807124 cites W2004006404 @default.
• W2890807124 cites W2006326440 @default.
• W2890807124 cites W2014387049 @default.
• W2890807124 cites W2025109572 @default.
• W2890807124 cites W2028804415 @default.
• W2890807124 cites W2029765949 @default.
• W2890807124 cites W2030544564 @default.
• W2890807124 cites W2040145532 @default.
• W2890807124 cites W2040992522 @default.
• W2890807124 cites W2042756123 @default.
• W2890807124 cites W2044024822 @default.
• W2890807124 cites W2048823459 @default.
• W2890807124 cites W2051202148 @default.
• W2890807124 cites W2060634498 @default.
• W2890807124 cites W2069506836 @default.
• W2890807124 cites W2071888159 @default.
• W2890807124 cites W2081179079 @default.
• W2890807124 cites W2082660870 @default.
• W2890807124 cites W2083770395 @default.
• W2890807124 cites W2085188303 @default.
• W2890807124 cites W2095148496 @default.
• W2890807124 cites W2097250144 @default.
• W2890807124 cites W2098188835 @default.
• W2890807124 cites W2098507748 @default.
• W2890807124 cites W2104133157 @default.
• W2890807124 cites W2116345430 @default.
• W2890807124 cites W2122326560 @default.
• W2890807124 cites W2128158076 @default.
• W2890807124 cites W2141983610 @default.
• W2890807124 cites W2143633673 @default.
• W2890807124 cites W2144614335 @default.
• W2890807124 cites W2145700610 @default.
• W2890807124 cites W2149556691 @default.
• W2890807124 cites W2158918353 @default.
• W2890807124 cites W2169811933 @default.
• W2890807124 cites W2170366300 @default.
• W2890807124 cites W2198248975 @default.
• W2890807124 cites W2203901550 @default.
• W2890807124 cites W2281608468 @default.
• W2890807124 cites W2287874371 @default.
• W2890807124 cites W2335837419 @default.
• W2890807124 cites W2346208534 @default.
• W2890807124 cites W2413240603 @default.
• W2890807124 cites W2473428003 @default.
• W2890807124 cites W2528566921 @default.
• W2890807124 cites W2530601870 @default.
• W2890807124 cites W2572695447 @default.
• W2890807124 cites W2593832269 @default.
• W2890807124 cites W2611950122 @default.
• W2890807124 cites W2746607837 @default.
• W2890807124 cites W2753759476 @default.
• W2890807124 cites W2756319474 @default.
• W2890807124 cites W2757089421 @default.
• W2890807124 cites W2789851293 @default.
• W2890807124 cites W2800333448 @default.
• W2890807124 cites W4226151179 @default.
• W2890807124 doi "https://doi.org/10.1088/1361-6560/aadf24" @default.
• W2890807124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6207451" @default.
• W2890807124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30183674" @default.
• W2890807124 hasPublicationYear "2018" @default.
• W2890807124 type Work @default.
• W2890807124 sameAs 2890807124 @default.
• W2890807124 citedByCount "11" @default.
• W2890807124 countsByYear W28908071242019 @default.
• W2890807124 countsByYear W28908071242020 @default.
• W2890807124 countsByYear W28908071242021 @default.
• W2890807124 countsByYear W28908071242022 @default.
• W2890807124 countsByYear W28908071242023 @default.
• W2890807124 crossrefType "journal-article" @default.
• W2890807124 hasAuthorship W2890807124A5005317598 @default.
• W2890807124 hasAuthorship W2890807124A5023459910 @default.
• W2890807124 hasAuthorship W2890807124A5037938903 @default.
• W2890807124 hasAuthorship W2890807124A5044225007 @default.
• W2890807124 hasAuthorship W2890807124A5072499473 @default.
• W2890807124 hasBestOaLocation W28908071242 @default.
• W2890807124 hasConcept C105795698 @default.
• W2890807124 hasConcept C111337013 @default.
• W2890807124 hasConcept C11928243 @default.
• W2890807124 hasConcept C121332964 @default.
• W2890807124 hasConcept C178790620 @default.
• W2890807124 hasConcept C185544564 @default.
• W2890807124 hasConcept C185592680 @default.
• W2890807124 hasConcept C19499675 @default.

• next