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- W2890812419 abstract "Little is known about the challenging treatment of pediatric patients with hemophilia B and inhibitors due to disease rarity. We describe three patients diagnosed in childhood and followed up to 9 years. All three had allergic reactions to Factor IX, but two were later safely treated for bleeding episodes with activated prothrombin complex concentrates (APCC = FEIBA). The third was given only recombinant activated Factor VIIa. Based on ex vivo thrombin generation analysis, a new alternative treatment of combined bypassing agents was administered for bleeding episodes and several minor surgical procedures with no treatment-associated adverse events or thrombosis." @default.
- W2890812419 created "2018-09-27" @default.
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- W2890812419 date "2018-09-19" @default.
- W2890812419 modified "2023-09-25" @default.
- W2890812419 title "Alternative treatment options for pediatric hemophilia B patients with high-responding inhibitors: A thrombin generation-guided study" @default.
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- W2890812419 doi "https://doi.org/10.1002/pbc.27381" @default.
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