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- W2890814541 abstract "Pregnancy places a very high demand on physical, physiological and immunological responses of females,especially when aggravated by parasitic infestation. There is strong evidence that maternal infestations with helminth haveprofound effects on immunity to helminths and other pathogens. This case-control study involved 245 pregnant women aged18-40 years (>30 weeks of gestation) recruited from three secondary level hospitals in Ibadan, Nigeria. Morning stoolsamples collected from pregnant women were examine for intestinal helminths using formol-ether concentration method. Atotal of 38 participants comprising 17 Helminth Positive (HP) and 21 Helminth Negative (HN) pregnant women werepurposely selected for the study. Sera from these women (38) and their babies' cord (38) were analysed for immune factors[interleukins 6 and 8 (IL-6, IL-8), tumor necrosis factor-alpha (TNF-α) and immunoglobulin E (IgE)] were analyzed usingELISA. Anthropometric indices [weight and height in mothers and babies and Chest Circumference (CC) in babies] weremeasured using standard methods. Data were subjected to descriptive statistics and analysed using Student t-test and Pearsoncorrelation at α0.05. Only Ascaris lumbricoides was found in the 17 (6.9%) infested pregnant women. The mean levels of IL-6 (57.8 ± 32.8 vs 52.8±39.6 pg/mL), IL-8 (24.3±3.5 vs 22.0±7.1 pg/mL) and IgE (333.3±96.6 vs 242.3±96.8 IU/mL) weresimilar in HP when compared with HN. In cord sera, IL-8 level was significantly higher in babies of HP (23.7±3.9 pg/mL)compared with babies of HN (20.1±5.9 pg/mL). The levels of IL-6, TNF-α and nutritional indices in HP had significantpositive correlation with corresponding levels in babies of HP mothers. Only CC was significantly lowered in babies of HPcompared with HN mothers. Other anthropometric indices were not significantly different. Therefore, this present studysuggests that helminth infestation may lead to strong Th2 immune responses as is reflected by the cytokine levels of mothersand babies as well as anthropometric measurements of babies of infested mothers. The outcomes of this study provide basisto deworm pregnant women during pregnancy." @default.
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- W2890814541 date "2018-06-30" @default.
- W2890814541 modified "2023-09-24" @default.
- W2890814541 title "Serum Levels of Inflammatory Cytokines in Helminth Infested Pregnant Women and Cord Blood of their Babies in Relation to Pregnancy Outcome." @default.
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