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- W2890816500 abstract "To determine the occurrence of deletion of the long arm of chromosome 20 in cytogenetic studies of multiple myeloma patients. A retrospective study of cytogenetic studies from patients with a diagnosis of multiple myeloma was undertaken to determine the most common cytogenetic abnormalities identified. A total of 456 patients with at least four cytogenetic studies from the past 10 years were reviewed. Of these patients, 135 (29.6%) exhibited abnormal chromosomes within the period of the review. Of the abnormal results, 33 (24.4%) had an abnormality involving one chromosome, and 101 (74.4%) had abnormalities involving more than one chromosome. One abnormal result was determined to be constitutional (.8%) of the abnormal and 0.22% of the total patients. The most common single-chromosome abnormality was a deletion of the long arm of chromosome 20. A total of 17 of the 33 patients (51.5%) exhibited this abnormality. The next most numerous of this type of abnormality included four (12.1%) patients with a deletion of the long arm of 13. Two (6%) patients had a deletion of the long arm of chromosome 5. Further investigation is required to determine if these deletions are related to the initial diagnosis of multiple myeloma or are a secondary treatment-induced myeloid disorder." @default.
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- W2890816500 date "2018-09-21" @default.
- W2890816500 modified "2023-09-25" @default.
- W2890816500 title "Evaluation of the Presence of Deletion of the Long Arm of Chromosome 20 in Multiple Myeloma" @default.
- W2890816500 doi "https://doi.org/10.1093/ajcp/aqy097.276" @default.
- W2890816500 hasPublicationYear "2018" @default.
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