FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890819650> ?p ?o ?g. }

• W2890819650 endingPage "393" @default.
• W2890819650 startingPage "387" @default.
• W2890819650 abstract "One aspect of smoking and lung cancer that has not been closely examined, is that regarding genes that may predispose to tobacco dependence. Smoking and mental illness are tightly linked, apparently the result of smokers using cigarettes to self-medicate for mental problems. The gene for solute carrier family 18 member A1 (vesicular monoamine transporter; SLC18A1) is of particular interest in this regard because of its association with schizophrenia, autism and bipolar illness as well as with cancer. In the current study, the relationship of SLC18A1 expression with smoking and lung cancer was analyzed.The association between smoking, SLC18A1 expression and overall survival in the lung cancer dataset in The Cancer Genome Atlas was evaluated using the Genomic Data Commons Data Portal (https://portal.gdc.cancer.gov), as well as CbioPortal for Cancer Genomics (http://www.cbioportal.org) and the University of California Santa Cruz Xena browser (https://xenabrowser.net).Increased expression of SLC18A1 was found to be associated with a significantly increased survival in patients with adenocarcinoma (p=0.0058), but not those with squamous carcinoma (p=0.96). Lifelong never-smokers had the highest SLC18A1 expression. In the Pan Cancer Atlas, increased expression of SLC18A1 places such a tumor in group C5, among immunologically-quiet tumors.Most never-smokers with lung cancer do not respond to immune checkpoint inhibitors (ICIs). But for unknown reasons, a small proportion do show clinical benefit from the ICI pembrolizumab. Because of the good response of this group, it may be worthwhile assessing their SLC18A1 expression pre-treatment as a marker for potential clinical benefit. If SLC18A1 expression is low, a never-smoker may respond well to ICIs. High levels of expression would indicate a C5 tumor less likely to respond to ICIs. SLC18A1 might complement other biomarkers currently under study in relation to programmed cell death protein 1/programmed cell death protein ligand 1 inhibition." @default.
• W2890819650 created "2018-09-27" @default.
• W2890819650 creator A5014129971 @default.
• W2890819650 creator A5075008841 @default.
• W2890819650 date "2018-01-01" @default.
• W2890819650 modified "2023-09-23" @default.
• W2890819650 title "Expression of the Vesicular Monoamine Transporter Gene Solute Carrier Family 18 Member 1 (SLC18A1) in Lung Cancer" @default.
• W2890819650 cites W1503899947 @default.
• W2890819650 cites W1539205926 @default.
• W2890819650 cites W1551350294 @default.
• W2890819650 cites W1805091329 @default.
• W2890819650 cites W2039487334 @default.
• W2890819650 cites W2048337655 @default.
• W2890819650 cites W2049553585 @default.
• W2890819650 cites W2094494741 @default.
• W2890819650 cites W2114843025 @default.
• W2890819650 cites W2118081678 @default.
• W2890819650 cites W2121477496 @default.
• W2890819650 cites W2151809687 @default.
• W2890819650 cites W2155654588 @default.
• W2890819650 cites W2162722107 @default.
• W2890819650 cites W2163733282 @default.
• W2890819650 cites W2253129521 @default.
• W2890819650 cites W2255181126 @default.
• W2890819650 cites W2280154361 @default.
• W2890819650 cites W2337092408 @default.
• W2890819650 cites W2408237782 @default.
• W2890819650 cites W2560290489 @default.
• W2890819650 cites W2560367415 @default.
• W2890819650 cites W2572174216 @default.
• W2890819650 cites W2606592417 @default.
• W2890819650 cites W2607211817 @default.
• W2890819650 cites W2610213110 @default.
• W2890819650 cites W2621587943 @default.
• W2890819650 cites W2730090387 @default.
• W2890819650 cites W2742449822 @default.
• W2890819650 cites W2751085315 @default.
• W2890819650 cites W2796207838 @default.
• W2890819650 cites W2796582438 @default.
• W2890819650 cites W2797675588 @default.
• W2890819650 doi "https://doi.org/10.21873/cgp.20097" @default.
• W2890819650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199572" @default.
• W2890819650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30194079" @default.
• W2890819650 hasPublicationYear "2018" @default.
• W2890819650 type Work @default.
• W2890819650 sameAs 2890819650 @default.
• W2890819650 citedByCount "3" @default.
• W2890819650 countsByYear W28908196502021 @default.
• W2890819650 countsByYear W28908196502023 @default.
• W2890819650 crossrefType "journal-article" @default.
• W2890819650 hasAuthorship W2890819650A5014129971 @default.
• W2890819650 hasAuthorship W2890819650A5075008841 @default.
• W2890819650 hasBestOaLocation W28908196502 @default.
• W2890819650 hasConcept C121608353 @default.
• W2890819650 hasConcept C126322002 @default.
• W2890819650 hasConcept C143998085 @default.
• W2890819650 hasConcept C2776256026 @default.
• W2890819650 hasConcept C2781182431 @default.
• W2890819650 hasConcept C71924100 @default.
• W2890819650 hasConceptScore W2890819650C121608353 @default.
• W2890819650 hasConceptScore W2890819650C126322002 @default.
• W2890819650 hasConceptScore W2890819650C143998085 @default.
• W2890819650 hasConceptScore W2890819650C2776256026 @default.
• W2890819650 hasConceptScore W2890819650C2781182431 @default.
• W2890819650 hasConceptScore W2890819650C71924100 @default.
• W2890819650 hasIssue "5" @default.
• W2890819650 hasLocation W28908196501 @default.
• W2890819650 hasLocation W28908196502 @default.
• W2890819650 hasLocation W28908196503 @default.
• W2890819650 hasLocation W28908196504 @default.
• W2890819650 hasOpenAccess W2890819650 @default.
• W2890819650 hasPrimaryLocation W28908196501 @default.
• W2890819650 hasRelatedWork W1602357875 @default.
• W2890819650 hasRelatedWork W2372561159 @default.
• W2890819650 hasRelatedWork W2390152934 @default.
• W2890819650 hasRelatedWork W2403361534 @default.
• W2890819650 hasRelatedWork W2472792300 @default.
• W2890819650 hasRelatedWork W2743740828 @default.
• W2890819650 hasRelatedWork W2888534976 @default.
• W2890819650 hasRelatedWork W2908922480 @default.
• W2890819650 hasRelatedWork W3171615116 @default.
• W2890819650 hasRelatedWork W4200188553 @default.
• W2890819650 hasVolume "15" @default.
• W2890819650 isParatext "false" @default.
• W2890819650 isRetracted "false" @default.
• W2890819650 magId "2890819650" @default.
• W2890819650 workType "article" @default.