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- W2890820050 abstract "Despite a growing body of evidence, the role of the gut microbiome in cardiovascular diseases is still unclear. Here, we present a systems-genome-wide and metagenome-wide association study on plasma concentrations of 92 cardiovascular-disease-related proteins in the population cohort LifeLines-DEEP. We identified genetic components for 73 proteins and microbial associations for 41 proteins, of which 31 were associated to both. The genetic and microbial factors identified mostly exert additive effects and collectively explain up to 76.6% of inter-individual variation (17.5% on average). Genetics contribute most to concentrations of immune-related proteins, while the gut microbiome contributes most to proteins involved in metabolism and intestinal health. We found several host-microbe interactions that impact proteins involved in epithelial function, lipid metabolism, and central nervous system function. This study provides important evidence for a joint genetic and microbial effect in cardiovascular disease and provides directions for future applications in personalized medicine." @default.
- W2890820050 created "2018-09-27" @default.
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- W2890820050 date "2018-09-24" @default.
- W2890820050 modified "2023-09-27" @default.
- W2890820050 title "Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome" @default.
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- W2890820050 cites W1928735440 @default.
- W2890820050 cites W1963944471 @default.
- W2890820050 cites W1970054229 @default.
- W2890820050 cites W1980289829 @default.
- W2890820050 cites W1986082361 @default.
- W2890820050 cites W1988835634 @default.
- W2890820050 cites W1989314123 @default.
- W2890820050 cites W1997544016 @default.
- W2890820050 cites W2008957118 @default.
- W2890820050 cites W2010084870 @default.
- W2890820050 cites W2018838463 @default.
- W2890820050 cites W2028635560 @default.
- W2890820050 cites W2035837169 @default.
- W2890820050 cites W2039153962 @default.
- W2890820050 cites W2055741797 @default.
- W2890820050 cites W2056427417 @default.
- W2890820050 cites W2059503514 @default.
- W2890820050 cites W2060013640 @default.
- W2890820050 cites W2061554433 @default.
- W2890820050 cites W2068115215 @default.
- W2890820050 cites W2068653999 @default.
- W2890820050 cites W2070978075 @default.
- W2890820050 cites W2071841602 @default.
- W2890820050 cites W2086251986 @default.
- W2890820050 cites W2095714503 @default.
- W2890820050 cites W2096173332 @default.
- W2890820050 cites W2097630554 @default.
- W2890820050 cites W2099125766 @default.
- W2890820050 cites W2099143842 @default.
- W2890820050 cites W2103516623 @default.
- W2890820050 cites W2111583269 @default.
- W2890820050 cites W2111708038 @default.
- W2890820050 cites W2112738213 @default.
- W2890820050 cites W2114772072 @default.
- W2890820050 cites W2117088514 @default.
- W2890820050 cites W2119862467 @default.
- W2890820050 cites W2128088446 @default.
- W2890820050 cites W2132731072 @default.
- W2890820050 cites W2133808995 @default.
- W2890820050 cites W2134526812 @default.
- W2890820050 cites W2135199713 @default.
- W2890820050 cites W2135787796 @default.
- W2890820050 cites W2136759951 @default.
- W2890820050 cites W2139904925 @default.
- W2890820050 cites W2144393300 @default.
- W2890820050 cites W2145154276 @default.
- W2890820050 cites W2147790901 @default.
- W2890820050 cites W2150527855 @default.
- W2890820050 cites W2157349032 @default.
- W2890820050 cites W2159565522 @default.
- W2890820050 cites W2159675211 @default.
- W2890820050 cites W2166864139 @default.
- W2890820050 cites W2167700091 @default.
- W2890820050 cites W2169456326 @default.
- W2890820050 cites W2206854629 @default.
- W2890820050 cites W2212228100 @default.
- W2890820050 cites W2228194427 @default.
- W2890820050 cites W2262330054 @default.
- W2890820050 cites W2274927794 @default.
- W2890820050 cites W2280819535 @default.
- W2890820050 cites W2284521682 @default.
- W2890820050 cites W2344543878 @default.
- W2890820050 cites W2510773831 @default.
- W2890820050 cites W2510973425 @default.
- W2890820050 cites W2511515754 @default.
- W2890820050 cites W2518292433 @default.
- W2890820050 cites W2528524934 @default.
- W2890820050 cites W2528599788 @default.
- W2890820050 cites W2529692498 @default.
- W2890820050 cites W2550031966 @default.
- W2890820050 cites W2556090133 @default.
- W2890820050 cites W2560048039 @default.
- W2890820050 cites W2566116513 @default.