Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890820189> ?p ?o ?g. }
- W2890820189 abstract "The plant transmembrane receptor kinase FLAGELLIN SENSING 2 (FLS2) is crucial for innate immunity. Although previous studies have reported FLS2-mediated signal transduction and endocytosis via the clathrin-mediated pathway, whether additional endocytic pathways affect FLS2-mediated defense responses remains unclear. Here, we show that the Arabidopsis thaliana sterol-deficient mutant steroid methyltransferase 1 displays defects in immune responses induced by the flagellin-derived peptide flg22. Variable-angle total internal reflection fluorescence microscopy (VA-TIRFM) coupled with single-particle tracking showed that the spatiotemporal dynamics of FLS2-GFP changed on a millisecond time scale and that the FLS2-GFP dwell time at the plasma membrane increased in cells treated with a sterol-extracting reagent when compared with untreated counterparts. We further demonstrate that flg22-induced FLS2 clustering and endocytosis involves the sterol-associated endocytic pathway, which is distinct from the clathrin-mediated pathway. Moreover, flg22 enhanced the colocalization of FLS2-GFP with the membrane microdomain marker Flot 1-mCherry and FLS2 endocytosis via the sterol-associated pathway. This indicates that plants may respond to pathogen attacks by regulating two different endocytic pathways. Taken together, our results suggest the key role of sterol homeostasis in flg22-induced plant defense responses." @default.
- W2890820189 created "2018-09-27" @default.
- W2890820189 creator A5003274991 @default.
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- W2890820189 date "2018-01-01" @default.
- W2890820189 modified "2023-10-18" @default.
- W2890820189 title "Sterols regulate endocytic pathways during flg22-induced defense responses in <i>Arabidopsis</i>" @default.
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- W2890820189 doi "https://doi.org/10.1242/dev.165688" @default.
- W2890820189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30228101" @default.
- W2890820189 hasPublicationYear "2018" @default.
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