FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890825692> ?p ?o ?g. }

• W2890825692 endingPage "e0203331" @default.
• W2890825692 startingPage "e0203331" @default.
• W2890825692 abstract "Zika virus (ZIKV), an arthropod-borne virus, has emerged as a major human pathogen. Prolonged or persistent ZIKV infection of human cells and tissues may serve as a reservoir for the virus and present serious challenges to the safety of public health. Human hematopoietic cell lines with different developmental properties revealed differences in susceptibility and outcomes to ZIKV infection. In three separate studies involving the prototypic MR 766 ZIKV strain and the human monocytic leukemia U937 cell line, ZIKV initially developed only a low-grade infection at a slow rate. After continuous culture for several months, persistently ZIKV-infected cell lines were observed with most, if not all, cells testing positive for ZIKV antigen. The infected cultures produced ZIKV RNA (v-RNA) and infectious ZIKVs persistently (persistent ZIKVs) with distinct infectivity and pathogenicity when tested using various kinds of host cells. When the genomes of ZIKVs from the three persistently infected cell lines were compared with the genome of the prototypic MR 766 ZIKV strain, distinct sets of mutations specific to each cell line were found. Significantly, all three persistent ZIKVs were capable of infecting fresh U937 cells with high efficiency at rapid rates, resulting in the development of a new set of persistently ZIKV-infected U937 cell lines. The genomes of ZIKVs from the new set of persistently ZIKV-infected U937 cell lines were further analyzed for their different mutations. The 2nd generation of persistent ZIKVs continued to possess most of the distinct sets of mutations specific to the respective 1st generation of persistent ZIKVs. We anticipate that the study will contribute to the understanding of the fundamental biology of adaptive mutations and selection during viral persistence. The persistently ZIKV-infected human cell lines that we developed will also be useful to investigate critical molecular pathways of ZIKV persistence and to study drugs or countermeasures against ZIKV infections and transmission." @default.
• W2890825692 created "2018-09-27" @default.
• W2890825692 creator A5002513159 @default.
• W2890825692 creator A5009062717 @default.
• W2890825692 creator A5013415135 @default.
• W2890825692 creator A5033357672 @default.
• W2890825692 creator A5047033557 @default.
• W2890825692 creator A5053274397 @default.
• W2890825692 creator A5080529923 @default.
• W2890825692 creator A5085933304 @default.
• W2890825692 creator A5088009190 @default.
• W2890825692 date "2018-09-07" @default.
• W2890825692 modified "2023-10-05" @default.
• W2890825692 title "Comparative genomics, infectivity and cytopathogenicity of Zika viruses produced by acutely and persistently infected human hematopoietic cell lines" @default.
• W2890825692 cites W1974965086 @default.
• W2890825692 cites W2017469817 @default.
• W2890825692 cites W2027367697 @default.
• W2890825692 cites W2029052029 @default.
• W2890825692 cites W2039772376 @default.
• W2890825692 cites W2042530028 @default.
• W2890825692 cites W2060303925 @default.
• W2890825692 cites W2068167401 @default.
• W2890825692 cites W2079967495 @default.
• W2890825692 cites W2101025196 @default.
• W2890825692 cites W2117692528 @default.
• W2890825692 cites W2139882675 @default.
• W2890825692 cites W2144970270 @default.
• W2890825692 cites W2272004514 @default.
• W2890825692 cites W2285713692 @default.
• W2890825692 cites W2289704315 @default.
• W2890825692 cites W2289738337 @default.
• W2890825692 cites W2423337363 @default.
• W2890825692 cites W2507412157 @default.
• W2890825692 cites W2508596867 @default.
• W2890825692 cites W2509082591 @default.
• W2890825692 cites W2521079522 @default.
• W2890825692 cites W2552845139 @default.
• W2890825692 cites W2583367536 @default.
• W2890825692 cites W2588207387 @default.
• W2890825692 cites W2591900972 @default.
• W2890825692 cites W2592541537 @default.
• W2890825692 cites W2593884546 @default.
• W2890825692 cites W2609504358 @default.
• W2890825692 cites W2759977828 @default.
• W2890825692 cites W2760364797 @default.
• W2890825692 cites W2761047964 @default.
• W2890825692 cites W2778292808 @default.
• W2890825692 cites W2780685964 @default.
• W2890825692 cites W2782897656 @default.
• W2890825692 cites W2790778674 @default.
• W2890825692 cites W2792732323 @default.
• W2890825692 cites W3030907412 @default.
• W2890825692 cites W4292226710 @default.
• W2890825692 cites W2575520328 @default.
• W2890825692 doi "https://doi.org/10.1371/journal.pone.0203331" @default.
• W2890825692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6128475" @default.
• W2890825692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30192813" @default.
• W2890825692 hasPublicationYear "2018" @default.
• W2890825692 type Work @default.
• W2890825692 sameAs 2890825692 @default.
• W2890825692 citedByCount "4" @default.
• W2890825692 countsByYear W28908256922018 @default.
• W2890825692 countsByYear W28908256922019 @default.
• W2890825692 countsByYear W28908256922020 @default.
• W2890825692 crossrefType "journal-article" @default.
• W2890825692 hasAuthorship W2890825692A5002513159 @default.
• W2890825692 hasAuthorship W2890825692A5009062717 @default.
• W2890825692 hasAuthorship W2890825692A5013415135 @default.
• W2890825692 hasAuthorship W2890825692A5033357672 @default.
• W2890825692 hasAuthorship W2890825692A5047033557 @default.
• W2890825692 hasAuthorship W2890825692A5053274397 @default.
• W2890825692 hasAuthorship W2890825692A5080529923 @default.
• W2890825692 hasAuthorship W2890825692A5085933304 @default.
• W2890825692 hasAuthorship W2890825692A5088009190 @default.
• W2890825692 hasBestOaLocation W28908256921 @default.
• W2890825692 hasConcept C104317684 @default.
• W2890825692 hasConcept C106358424 @default.
• W2890825692 hasConcept C108634530 @default.
• W2890825692 hasConcept C109159458 @default.
• W2890825692 hasConcept C141231307 @default.
• W2890825692 hasConcept C159047783 @default.
• W2890825692 hasConcept C2522874641 @default.
• W2890825692 hasConcept C2777053367 @default.
• W2890825692 hasConcept C28328180 @default.
• W2890825692 hasConcept C54355233 @default.
• W2890825692 hasConcept C81885089 @default.
• W2890825692 hasConcept C86803240 @default.
• W2890825692 hasConcept C98108389 @default.
• W2890825692 hasConceptScore W2890825692C104317684 @default.
• W2890825692 hasConceptScore W2890825692C106358424 @default.
• W2890825692 hasConceptScore W2890825692C108634530 @default.
• W2890825692 hasConceptScore W2890825692C109159458 @default.
• W2890825692 hasConceptScore W2890825692C141231307 @default.
• W2890825692 hasConceptScore W2890825692C159047783 @default.
• W2890825692 hasConceptScore W2890825692C2522874641 @default.
• W2890825692 hasConceptScore W2890825692C2777053367 @default.
• W2890825692 hasConceptScore W2890825692C28328180 @default.
• W2890825692 hasConceptScore W2890825692C54355233 @default.

• next